CRCGN013_HEPG2_24H:L14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description emodin 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN013_HEPG2_24H:L14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 5.58818
LCN2 lipocalin 2 5.55483
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.5471
TXNRD1 thioredoxin reductase 1 5.52797
UGDH UDP-glucose 6-dehydrogenase 4.94504
HLA-DRA major histocompatibility complex, class II, DR alpha 4.39408
BZW2 basic leucine zipper and W2 domains 2 4.29682
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.24989
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.98132
CHN1 chimerin 1 3.93577
CYCS cytochrome c, somatic 3.70355
HLA-DMA major histocompatibility complex, class II, DM alpha 3.56386
KEAP1 kelch-like ECH-associated protein 1 3.32355
DYNLT3 dynein, light chain, Tctex-type 3 3.14797
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.08584
PPARG peroxisome proliferator-activated receptor gamma 3.03654
NOTCH1 notch 1 3.02099
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.00948
UBQLN2 ubiquilin 2 2.88828
MYLK myosin light chain kinase 2.88536
ABHD4 abhydrolase domain containing 4 2.85551
E2F2 E2F transcription factor 2 2.78621
ADAT1 adenosine deaminase, tRNA-specific 1 2.75772
ADGRE5 adhesion G protein-coupled receptor E5 2.69762
GATA3 GATA binding protein 3 2.64274
PRR15L proline rich 15-like 2.47806
CCNF cyclin F 2.4053
ANO1 anoctamin 1, calcium activated chloride channel 2.37658
USP6NL USP6 N-terminal like 2.32468
CBR1 carbonyl reductase 1 2.31848
MMP1 matrix metallopeptidase 1 2.27895
NUP42 nucleoporin 42 2.2786
RRAGA Ras-related GTP binding A 2.25232
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.16618
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.1637
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.14179
SQSTM1 sequestosome 1 2.07444
METTL8 methyltransferase like 8 2.04088

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.48214
GNAS GNAS complex locus -4.95325
CCNB2 cyclin B2 -4.57809
DNM1L dynamin 1-like -4.2396
CDC20 cell division cycle 20 -4.22592
TP53BP2 tumor protein p53 binding protein 2 -3.61078
OXA1L oxidase (cytochrome c) assembly 1-like -3.53822
LOC124907782 dual specificity protein phosphatase 22 -3.28452
LAP3 leucine aminopeptidase 3 -3.17268
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.03859
KDM3A lysine (K)-specific demethylase 3A -2.91652
NRIP1 nuclear receptor interacting protein 1 -2.66306
DSG2 desmoglein 2 -2.60293
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.55643
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.4917
DUSP6 dual specificity phosphatase 6 -2.45683
VAT1 vesicle amine transport 1 -2.30005
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.23538
TSPAN4 tetraspanin 4 -2.21152
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.20104
BACE1 beta-site APP-cleaving enzyme 1 -2.16148
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -2.10813
LMBR1L limb development membrane protein 1-like -2.09324
PHKA2 phosphorylase kinase, alpha 2 (liver) -2.0929
ADI1 acireductone dioxygenase 1 -2.01594