CRCGN013_HEPG2_24H:L15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description emodin 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN013_HEPG2_24H:L15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.90471
LYN LYN proto-oncogene, Src family tyrosine kinase 5.56933
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.99135
STK10 serine/threonine kinase 10 3.94623
RPP38 ribonuclease P/MRP 38kDa subunit 3.89776
C2CD2 C2 calcium-dependent domain containing 2 3.7059
HLA-DMA major histocompatibility complex, class II, DM alpha 3.6778
MYLK myosin light chain kinase 3.57129
PPARG peroxisome proliferator-activated receptor gamma 3.3875
NOSIP nitric oxide synthase interacting protein 3.36872
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 3.3678
LCN2 lipocalin 2 3.32344
AMDHD2 amidohydrolase domain containing 2 3.11805
ATP11B ATPase, class VI, type 11B 2.9674
HOXA10 homeobox A10 2.95397
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.91485
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.70764
TXNRD1 thioredoxin reductase 1 2.70026
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.4918
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.45388
PFKL phosphofructokinase, liver 2.40114
UGDH UDP-glucose 6-dehydrogenase 2.3295
GSTZ1 glutathione S-transferase zeta 1 2.3055
MAST2 microtubule associated serine/threonine kinase 2 2.27543
TOR3A torsin family 3, member A 2.26594
JADE2 jade family PHD finger 2 2.1951
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.19062
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.05865
ABHD4 abhydrolase domain containing 4 2.00915

decreased expression

Symbol Name Standardized Value
BLCAP bladder cancer associated protein -4.90644
TLCD3A TLC domain containing 3A -3.97875
COG7 component of oligomeric golgi complex 7 -3.6529
OXA1L oxidase (cytochrome c) assembly 1-like -3.6446
TSPAN4 tetraspanin 4 -3.61345
CCDC86 coiled-coil domain containing 86 -3.61177
MAP7 microtubule-associated protein 7 -3.3981
MRPS2 mitochondrial ribosomal protein S2 -3.26191
ZNF586 zinc finger protein 586 -3.05887
TUBB6 tubulin, beta 6 class V -3.0488
LOC124907782 dual specificity protein phosphatase 22 -2.64664
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.57454
TMEM109 transmembrane protein 109 -2.49617
FGFR4 fibroblast growth factor receptor 4 -2.24609
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.22343
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.21144
MAPK13 mitogen-activated protein kinase 13 -2.15745
ACADL acyl-CoA dehydrogenase, long chain -2.11881
ZMIZ1 zinc finger, MIZ-type containing 1 -2.08792