CRCGN013_HEPG2_24H:L22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methyl-1-nitroanthraquinone 2.53 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

354 genes differentially expressed following the CRCGN013_HEPG2_24H:L22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 10.0
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
INPP1 inositol polyphosphate-1-phosphatase 8.61446
LRP10 low density lipoprotein receptor-related protein 10 8.48096
MICALL1 MICAL-like 1 8.05236
TIMP2 TIMP metallopeptidase inhibitor 2 6.94477
DDB2 damage-specific DNA binding protein 2, 48kDa 6.67018
BLCAP bladder cancer associated protein 6.53751
KIFBP kinesin family binding protein 5.78255
ASCC3 activating signal cointegrator 1 complex subunit 3 5.67331
SQOR sulfide quinone oxidoreductase 5.56669
GPC1 glypican 1 5.4776
EGR1 early growth response 1 5.38447
IER3 immediate early response 3 5.02143
TUBB6 tubulin, beta 6 class V 5.01435
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.82579
ABHD4 abhydrolase domain containing 4 4.79372
MVP major vault protein 4.71327
SMAD3 SMAD family member 3 4.44283
PRR15L proline rich 15-like 4.35912
FOSL1 FOS-like antigen 1 4.24323
ABHD6 abhydrolase domain containing 6 4.15803
DUSP14 dual specificity phosphatase 14 4.10938
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.02629
IL4R interleukin 4 receptor 4.01487
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.97929
NOTCH1 notch 1 3.96836
TOMM34 translocase of outer mitochondrial membrane 34 3.86088
RALB v-ral simian leukemia viral oncogene homolog B 3.84919
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.66336
CARMIL1 capping protein regulator and myosin 1 linker 1 3.65214
ADGRG1 adhesion G protein-coupled receptor G1 3.54236
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 3.44069
FOXJ3 forkhead box J3 3.43117
CBR3 carbonyl reductase 3 3.36696
CEMIP2 cell migration inducing hyaluronidase 2 3.3025
CTSL cathepsin L 3.2893
TIGAR TP53 induced glycolysis regulatory phosphatase 3.27938
ZMAT3 zinc finger, matrin-type 3 3.25168
EPHA2 EPH receptor A2 3.2195
DUSP6 dual specificity phosphatase 6 3.21843
CCDC92 coiled-coil domain containing 92 3.19854
TICAM1 toll-like receptor adaptor molecule 1 3.17417
SOX4 SRY (sex determining region Y)-box 4 3.14103
STX1A syntaxin 1A (brain) 3.12335
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 3.10877
SPTAN1 spectrin, alpha, non-erythrocytic 1 3.08618
CAB39 calcium binding protein 39 3.07925
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 3.01401
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 2.97941
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.96888
TWF2 twinfilin actin binding protein 2 2.95715
TERF2IP telomeric repeat binding factor 2, interacting protein 2.95313
TRIB1 tribbles pseudokinase 1 2.88722
TATDN2 TatD DNase domain containing 2 2.88391
MINDY1 MINDY lysine 48 deubiquitinase 1 2.87476
PRKCQ protein kinase C, theta 2.86306
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.85479
DUSP3 dual specificity phosphatase 3 2.83994
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.827
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.81955
CDKN2A cyclin-dependent kinase inhibitor 2A 2.8145
UNC13D unc-13 homolog D (C. elegans) 2.80909
EPHA3 EPH receptor A3 2.79803
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.74686
CASC3 cancer susceptibility candidate 3 2.74335
RBKS ribokinase 2.73357
TRIM32 tripartite motif containing 32 2.7173
MAPK13 mitogen-activated protein kinase 13 2.70996
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.68134
MACF1 microtubule-actin crosslinking factor 1 2.67538
BTG2 BTG family, member 2 2.6724
RALGDS ral guanine nucleotide dissociation stimulator 2.6695
ITCH itchy E3 ubiquitin protein ligase 2.66326
INTS3 integrator complex subunit 3 2.65093
RRAGA Ras-related GTP binding A 2.63583
ZNF79 zinc finger protein 79 2.62313
ITGAV integrin, alpha V 2.6165
MAP7D1 MAP7 domain containing 1 2.61371
PROCR protein C receptor, endothelial 2.6105
SUN2 Sad1 and UNC84 domain containing 2 2.60237
FAT1 FAT atypical cadherin 1 2.59981
BYSL bystin-like 2.58172
COL17A1 collagen, type XVII, alpha 1 2.57494
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.56629
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.56324
TRIP12 thyroid hormone receptor interactor 12 2.55112
YY1AP1 YY1 associated protein 1 2.52863
E2F2 E2F transcription factor 2 2.5284
CHIC2 cysteine-rich hydrophobic domain 2 2.52776
RIPK4 receptor-interacting serine-threonine kinase 4 2.52676
DCTN5 dynactin 5 (p25) 2.52645
RIOK3 RIO kinase 3 2.50374
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.49862
KLHL36 kelch-like family member 36 2.4901
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.4882
RAB21 RAB21, member RAS oncogene family 2.48762
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.48263
ITPKC inositol-trisphosphate 3-kinase C 2.47917
DSG2 desmoglein 2 2.46513
LIF leukemia inhibitory factor 2.45712
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.4543
LAP3 leucine aminopeptidase 3 2.45217
TUBG2 tubulin, gamma 2 2.44992
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.44793
SCRN1 secernin 1 2.44332
STOM stomatin 2.43123
VAT1 vesicle amine transport 1 2.4161
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.39105
NISCH nischarin 2.36999
PRKCD protein kinase C, delta 2.35557
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.34893
PORCN porcupine homolog (Drosophila) 2.33968
CEL carboxyl ester lipase 2.3381
BPHL biphenyl hydrolase-like (serine hydrolase) 2.3349
FDXR ferredoxin reductase 2.33065
SKIC2 SKI2 subunit of superkiller complex 2.31381
STAMBP STAM binding protein 2.30297
YIPF3 Yip1 domain family, member 3 2.29369
DOCK6 dedicator of cytokinesis 6 2.2914
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.28907
BAD BCL2-associated agonist of cell death 2.28383
MEAF6 MYST/Esa1-associated factor 6 2.28269
ANO1 anoctamin 1, calcium activated chloride channel 2.25875
UBE2H ubiquitin-conjugating enzyme E2H 2.25805
SMIM29 small integral membrane protein 29 2.25131
STK17A serine/threonine kinase 17a 2.23371
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.22932
XPC xeroderma pigmentosum, complementation group C 2.22864
HOXD11 homeobox D11 2.2231
CCND3 cyclin D3 2.21502
SCPEP1 serine carboxypeptidase 1 2.2135
UBAP1 ubiquitin associated protein 1 2.20925
AOPEP aminopeptidase O (putative) 2.20367
MXRA7 matrix-remodelling associated 7 2.19918
MUC13 mucin 13, cell surface associated 2.18702
PHACTR4 phosphatase and actin regulator 4 2.18383
GPN2 GPN-loop GTPase 2 2.17193
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.16413
SLC35F6 solute carrier family 35, member F6 2.15678
HOXA4 homeobox A4 2.15565
BAX BCL2-associated X protein 2.15367
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.14967
NGRN neugrin, neurite outgrowth associated 2.14536
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.14279
GADD45A growth arrest and DNA-damage-inducible, alpha 2.14057
DDR1 discoidin domain receptor tyrosine kinase 1 2.13772
ADNP activity-dependent neuroprotector homeobox 2.12749
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 2.126
C1QL1 complement component 1, q subcomponent-like 1 2.12204
IGFBP3 insulin-like growth factor binding protein 3 2.12143
TMEM59 transmembrane protein 59 2.1181
FLNB filamin B, beta 2.11487
SAR1B secretion associated, Ras related GTPase 1B 2.0947
ZYX zyxin 2.09117
ETV6 ets variant 6 2.09085
LTK leukocyte receptor tyrosine kinase 2.08973
ADGRE5 adhesion G protein-coupled receptor E5 2.08551
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.08515
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.08419
ELL2 elongation factor, RNA polymerase II, 2 2.08223
PLEC plectin 2.08173
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 2.08096
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.07087
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 2.0628
RTP4 receptor (chemosensory) transporter protein 4 2.05622
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.04831
GSDME gasdermin E 2.04819
MOK MOK protein kinase 2.04414
GIPC1 GIPC PDZ domain containing family, member 1 2.04234
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 2.0415
TMEM50A transmembrane protein 50A 2.0415
APOA4 apolipoprotein A-IV 2.04114
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.03635
BMPR1B bone morphogenetic protein receptor, type IB 2.03484
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.02902
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.02694
AFF4 AF4/FMR2 family, member 4 2.02563
CTPS1 CTP synthase 1 2.02193
RASAL2 RAS protein activator like 2 2.02165
TLE3 transducin-like enhancer of split 3 2.02006
CDIP1 cell death-inducing p53 target 1 2.01642
DCTN3 dynactin 3 (p22) 2.01564
KEAP1 kelch-like ECH-associated protein 1 2.00267
KLF3 Kruppel-like factor 3 (basic) 2.00174
ANXA11 annexin A11 2.0007

decreased expression

Symbol Name Standardized Value
FGFR4 fibroblast growth factor receptor 4 -7.70143
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -7.24795
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.69285
PYCR1 pyrroline-5-carboxylate reductase 1 -6.03307
ZW10 zw10 kinetochore protein -6.00926
ZDHHC6 zinc finger, DHHC-type containing 6 -5.82697
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.77274
PSRC1 proline/serine-rich coiled-coil 1 -5.71368
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -5.70469
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.67045
UGDH UDP-glucose 6-dehydrogenase -5.66296
C5 complement component 5 -5.37138
AURKB aurora kinase B -5.33356
NT5DC2 5'-nucleotidase domain containing 2 -5.27594
ISOC1 isochorismatase domain containing 1 -5.2131
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.1986
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.02662
SOAT2 sterol O-acyltransferase 2 -4.94254
TRIB3 tribbles pseudokinase 3 -4.92256
ALDOC aldolase C, fructose-bisphosphate -4.8887
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.86629
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -4.85838
PGM1 phosphoglucomutase 1 -4.83056
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.66463
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.63114
PECR peroxisomal trans-2-enoyl-CoA reductase -4.58929
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.47737
TCTN1 tectonic family member 1 -4.31494
CDK1 cyclin-dependent kinase 1 -4.24683
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -4.14008
CCNA2 cyclin A2 -4.11755
BLMH bleomycin hydrolase -3.76186
NIPSNAP1 nipsnap homolog 1 (C. elegans) -3.575
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.5712
C2CD5 C2 calcium-dependent domain containing 5 -3.52326
TP53BP2 tumor protein p53 binding protein 2 -3.38678
FBXO5 F-box protein 5 -3.37902
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.37739
LBR lamin B receptor -3.31769
FASTKD5 FAST kinase domains 5 -3.30858
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.29713
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.26549
TLCD3A TLC domain containing 3A -3.17175
TEDC2 tubulin epsilon and delta complex 2 -3.08822
MAP7 microtubule-associated protein 7 -3.08593
STMN1 stathmin 1 -3.06426
LDHD lactate dehydrogenase D -3.06047
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.04243
KIF14 kinesin family member 14 -2.993
SCD stearoyl-CoA desaturase (delta-9-desaturase) -2.946
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.86929
AARS1 alanyl-tRNA synthetase 1 -2.86155
USP1 ubiquitin specific peptidase 1 -2.82832
NUCB2 nucleobindin 2 -2.82344
HADH hydroxyacyl-CoA dehydrogenase -2.81454
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.80007
PLK1 polo-like kinase 1 -2.75726
PHGDH phosphoglycerate dehydrogenase -2.74483
KLHDC2 kelch domain containing 2 -2.73839
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.67638
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.65452
DUT deoxyuridine triphosphatase -2.61837
MIS18A MIS18 kinetochore protein A -2.60728
AKAP8 A kinase (PRKA) anchor protein 8 -2.60449
DENND2D DENN/MADD domain containing 2D -2.60341
FAM117A family with sequence similarity 117, member A -2.58775
A1CF APOBEC1 complementation factor -2.58698
PARG poly (ADP-ribose) glycohydrolase -2.58113
MSH6 mutS homolog 6 -2.57793
KTN1 kinectin 1 (kinesin receptor) -2.57708
MPC1 mitochondrial pyruvate carrier 1 -2.55701
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.55699
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.55555
UNG uracil-DNA glycosylase -2.52183
FBXO31 F-box protein 31 -2.51745
GNAS GNAS complex locus -2.51549
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -2.50885
CHEK1 checkpoint kinase 1 -2.49818
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.49487
PHF10 PHD finger protein 10 -2.4901
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.48275
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -2.47927
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.46762
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.45895
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.45546
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.43591
MSMO1 methylsterol monooxygenase 1 -2.42146
EXTL2 exostosin-like glycosyltransferase 2 -2.42018
POLK polymerase (DNA directed) kappa -2.41294
NFYB nuclear transcription factor Y, beta -2.40663
MTA1 metastasis associated 1 -2.40474
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.3991
LOC124907782 dual specificity protein phosphatase 22 -2.3909
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.38197
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.38069
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.34934
NRTN neurturin -2.34899
DSCC1 DNA replication and sister chromatid cohesion 1 -2.34892
ZNF302 zinc finger protein 302 -2.33443
ATL2 atlastin GTPase 2 -2.29991
NUP85 nucleoporin 85kDa -2.29664
VASH2 vasohibin 2 -2.29192
RIOX1 ribosomal oxygenase 1 -2.28874
CCNE1 cyclin E1 -2.28066
NECAB2 N-terminal EF-hand calcium binding protein 2 -2.27192
ASGR1 asialoglycoprotein receptor 1 -2.26817
EXT1 exostosin glycosyltransferase 1 -2.25839
TMEM97 transmembrane protein 97 -2.25541
ZSCAN5A zinc finger and SCAN domain containing 5A -2.2482
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -2.24217
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) -2.23789
CDO1 cysteine dioxygenase type 1 -2.23756
SLC30A3 solute carrier family 30 (zinc transporter), member 3 -2.23673
ERG28 ergosterol biosynthesis 28 homolog -2.23586
TRAPPC11 trafficking protein particle complex 11 -2.23042
VIPR1 vasoactive intestinal peptide receptor 1 -2.22841
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.22461
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) -2.21503
PAH phenylalanine hydroxylase -2.21013
KIF15 kinesin family member 15 -2.19451
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.1943
CDC6 cell division cycle 6 -2.19118
MSH2 mutS homolog 2 -2.18657
ASB13 ankyrin repeat and SOCS box containing 13 -2.18488
GPR27 G protein-coupled receptor 27 -2.18069
SLF2 SMC5-SMC6 complex localization factor 2 -2.17332
MSRA methionine sulfoxide reductase A -2.16593
HMGB2 high mobility group box 2 -2.15991
RHOBTB1 Rho-related BTB domain containing 1 -2.15353
TIMELESS timeless circadian clock -2.15093
DCP2 decapping mRNA 2 -2.14703
DNM1L dynamin 1-like -2.14643
CHMP6 charged multivesicular body protein 6 -2.13974
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -2.13482
LMBR1 limb development membrane protein 1 -2.12123
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.11681
PXMP2 peroxisomal membrane protein 2, 22kDa -2.11479
NFIL3 nuclear factor, interleukin 3 regulated -2.10906
ICAM3 intercellular adhesion molecule 3 -2.10566
SQLE squalene epoxidase -2.1034
CPNE3 copine III -2.09868
CLCN6 chloride channel, voltage-sensitive 6 -2.09738
GPT glutamic-pyruvate transaminase (alanine aminotransferase) -2.0956
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -2.09343
RPIA ribose 5-phosphate isomerase A -2.08983
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -2.08969
AMBP alpha-1-microglobulin/bikunin precursor -2.08645
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.0861
ZNF83 zinc finger protein 83 -2.08464
MYO10 myosin X -2.07989
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.07926
SLC22A14 solute carrier family 22, member 14 -2.07572
MYBPH myosin binding protein H -2.06778
PANK3 pantothenate kinase 3 -2.05479
TPSG1 tryptase gamma 1 -2.05302
BIRC5 baculoviral IAP repeat containing 5 -2.05102
HSPA1A heat shock 70kDa protein 1A -2.04783
GMCL1 germ cell-less, spermatogenesis associated 1 -2.04253
THAP11 THAP domain containing 11 -2.04202
HACL2 2-hydroxyacyl-CoA lyase 2 -2.03878
JMJD4 jumonji domain containing 4 -2.037
FLT3 fms-related tyrosine kinase 3 -2.03595
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -2.02443
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.01969
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.01961
CCP110 centriolar coiled coil protein 110kDa -2.01861
PRDX5 peroxiredoxin 5 -2.01296
STAC SH3 and cysteine rich domain -2.00431