CRCGN013_HEPG2_24H:L23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methyl-1-nitroanthraquinone 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

145 genes differentially expressed following the CRCGN013_HEPG2_24H:L23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
CNPY3 canopy FGF signaling regulator 3 9.27272
TIMP2 TIMP metallopeptidase inhibitor 2 6.54943
ASCC3 activating signal cointegrator 1 complex subunit 3 6.3605
MYLK myosin light chain kinase 6.29272
SSBP2 single-stranded DNA binding protein 2 5.74468
INPP1 inositol polyphosphate-1-phosphatase 5.68476
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.19951
TUBB6 tubulin, beta 6 class V 5.17145
DDB2 damage-specific DNA binding protein 2, 48kDa 5.11592
KIFBP kinesin family binding protein 5.07155
TIAM1 T-cell lymphoma invasion and metastasis 1 4.53485
MICALL1 MICAL-like 1 4.25484
GPC1 glypican 1 4.06023
MVP major vault protein 3.91543
NOTCH1 notch 1 3.85562
PPARG peroxisome proliferator-activated receptor gamma 3.82053
FOSL1 FOS-like antigen 1 3.7876
BLCAP bladder cancer associated protein 3.73725
LCN2 lipocalin 2 3.57112
LRP10 low density lipoprotein receptor-related protein 10 3.53762
TATDN2 TatD DNase domain containing 2 3.29782
SQOR sulfide quinone oxidoreductase 3.29402
EPHB2 EPH receptor B2 3.28261
HLA-DMA major histocompatibility complex, class II, DM alpha 3.1802
BZW2 basic leucine zipper and W2 domains 2 3.13473
CXCR4 chemokine (C-X-C motif) receptor 4 3.13054
ACOT9 acyl-CoA thioesterase 9 3.09304
RALB v-ral simian leukemia viral oncogene homolog B 3.05681
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 3.01996
DYNLT3 dynein, light chain, Tctex-type 3 2.97714
LAP3 leucine aminopeptidase 3 2.81893
EPHA2 EPH receptor A2 2.81221
XPC xeroderma pigmentosum, complementation group C 2.78104
DSG2 desmoglein 2 2.77925
TRIB1 tribbles pseudokinase 1 2.7702
UBQLN2 ubiquilin 2 2.76044
TOMM34 translocase of outer mitochondrial membrane 34 2.74661
TGFBI transforming growth factor, beta-induced, 68kDa 2.73004
MINDY1 MINDY lysine 48 deubiquitinase 1 2.66082
TWF2 twinfilin actin binding protein 2 2.64791
DUSP6 dual specificity phosphatase 6 2.61929
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.61779
DUSP14 dual specificity phosphatase 14 2.5212
NPDC1 neural proliferation, differentiation and control, 1 2.48621
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.46041
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.45054
GLRX glutaredoxin (thioltransferase) 2.43574
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.43263
ADGRG1 adhesion G protein-coupled receptor G1 2.39036
CYCS cytochrome c, somatic 2.3869
ABHD4 abhydrolase domain containing 4 2.37908
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.3565
SMAD3 SMAD family member 3 2.33304
IER3 immediate early response 3 2.28783
MAP7D1 MAP7 domain containing 1 2.28656
IL4R interleukin 4 receptor 2.2564
FAT1 FAT atypical cadherin 1 2.22837
VAT1 vesicle amine transport 1 2.2196
MACF1 microtubule-actin crosslinking factor 1 2.13674
PRKCD protein kinase C, delta 2.09804
ITGAV integrin, alpha V 2.08927
FRMD4B FERM domain containing 4B 2.01684

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -7.24972
FGFR4 fibroblast growth factor receptor 4 -7.24148
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.75667
NUP85 nucleoporin 85kDa -5.5676
UGDH UDP-glucose 6-dehydrogenase -4.82439
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.40592
ALDOC aldolase C, fructose-bisphosphate -4.3906
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.09331
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.99152
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.88663
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.87329
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.85143
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.82311
C2CD5 C2 calcium-dependent domain containing 5 -3.8223
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.74631
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.71619
TCTN1 tectonic family member 1 -3.60448
SOAT2 sterol O-acyltransferase 2 -3.53604
RFC2 replication factor C (activator 1) 2, 40kDa -3.4723
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.41674
PECR peroxisomal trans-2-enoyl-CoA reductase -3.28445
PGM1 phosphoglucomutase 1 -3.27266
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.16085
LDHD lactate dehydrogenase D -3.15563
ICAM3 intercellular adhesion molecule 3 -3.15334
PYCR1 pyrroline-5-carboxylate reductase 1 -3.04107
NIPSNAP1 nipsnap homolog 1 (C. elegans) -3.0182
KIF14 kinesin family member 14 -2.95709
RGS2 regulator of G-protein signaling 2 -2.94676
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.84256
HMG20B high mobility group 20B -2.70678
PCNA proliferating cell nuclear antigen -2.69113
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.68347
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.61658
LOC124907782 dual specificity protein phosphatase 22 -2.61529
BLMH bleomycin hydrolase -2.59153
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.56953
HADH hydroxyacyl-CoA dehydrogenase -2.53135
PHGDH phosphoglycerate dehydrogenase -2.53066
STMN1 stathmin 1 -2.51841
MSMO1 methylsterol monooxygenase 1 -2.50009
REEP5 receptor accessory protein 5 -2.491
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.46283
TRIB3 tribbles pseudokinase 3 -2.43167
TCERG1 transcription elongation regulator 1 -2.4266
PLK1 polo-like kinase 1 -2.40233
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 -2.38923
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.38862
USP6NL USP6 N-terminal like -2.37824
CCNA2 cyclin A2 -2.37344
NT5DC2 5'-nucleotidase domain containing 2 -2.34867
KCTD2 potassium channel tetramerization domain containing 2 -2.34701
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.34358
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.33826
PSRC1 proline/serine-rich coiled-coil 1 -2.31309
TK1 thymidine kinase 1, soluble -2.28314
CCNB2 cyclin B2 -2.25385
AURKB aurora kinase B -2.23471
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.22406
DDIT4 DNA-damage-inducible transcript 4 -2.2174
NOL11 nucleolar protein 11 -2.16601
MVD mevalonate (diphospho) decarboxylase -2.14801
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.13962
ERCC6L excision repair cross-complementation group 6-like -2.10988
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) -2.10823
DCP2 decapping mRNA 2 -2.10539
DCXR dicarbonyl/L-xylulose reductase -2.09938
IREB2 iron-responsive element binding protein 2 -2.09501
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.08286
GPALPP1 GPALPP motifs containing 1 -2.07884
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.07384
CBR1 carbonyl reductase 1 -2.06155
PGRMC1 progesterone receptor membrane component 1 -2.05334
AK4 adenylate kinase 4 -2.04557
VIPR1 vasoactive intestinal peptide receptor 1 -2.04052
BABAM1 BRISC and BRCA1 A complex member 1 -2.0375
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -2.03241
CDC20 cell division cycle 20 -2.03039
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.02769
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.01952
HAAO 3-hydroxyanthranilate 3,4-dioxygenase -2.01639
PPID peptidylprolyl isomerase D -2.00612