CRCGN013_HEPG2_24H:L24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methyl-1-nitroanthraquinone 0.63 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

123 genes differentially expressed following the CRCGN013_HEPG2_24H:L24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.5779
CDPF1 cysteine-rich, DPF motif domain containing 1 5.98409
CIAO3 cytosolic iron-sulfur assembly component 3 4.84412
CNPY3 canopy FGF signaling regulator 3 4.45158
MICALL1 MICAL-like 1 4.41377
INPP1 inositol polyphosphate-1-phosphatase 4.27664
GPER1 G protein-coupled estrogen receptor 1 4.253
ATP11B ATPase, class VI, type 11B 4.16242
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.95557
PPARG peroxisome proliferator-activated receptor gamma 3.9476
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.64126
CEMIP2 cell migration inducing hyaluronidase 2 3.60149
ASCC3 activating signal cointegrator 1 complex subunit 3 3.59749
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.5945
TUBB6 tubulin, beta 6 class V 3.40031
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.302
DDB2 damage-specific DNA binding protein 2, 48kDa 3.29745
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.26955
GPC1 glypican 1 3.2532
ABHD6 abhydrolase domain containing 6 3.21482
ANO1 anoctamin 1, calcium activated chloride channel 3.03974
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.99983
FOSL1 FOS-like antigen 1 2.97012
FCHO1 FCH domain only 1 2.89405
GLRX glutaredoxin (thioltransferase) 2.83647
BLCAP bladder cancer associated protein 2.80358
BAX BCL2-associated X protein 2.77095
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.7408
TIAM1 T-cell lymphoma invasion and metastasis 1 2.7033
LRP10 low density lipoprotein receptor-related protein 10 2.49863
TIMP2 TIMP metallopeptidase inhibitor 2 2.49536
KRTAP5-3 keratin associated protein 5-3 2.48498
FGF16 fibroblast growth factor 16 2.42107
ELOVL1 ELOVL fatty acid elongase 1 2.41043
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.40576
CCNH cyclin H 2.40113
MVP major vault protein 2.38038
ACOT8 acyl-CoA thioesterase 8 2.34524
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 2.34377
DUSP6 dual specificity phosphatase 6 2.33736
ZC4H2 zinc finger, C4H2 domain containing 2.24785
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.23571
CEPT1 choline/ethanolamine phosphotransferase 1 2.20728
AMBN ameloblastin (enamel matrix protein) 2.20367
DKK4 dickkopf WNT signaling pathway inhibitor 4 2.19272
EPS8L2 EPS8-like 2 2.18193
KLF3 Kruppel-like factor 3 (basic) 2.14839
UPK2 uroplakin 2 2.14155
ZNF257 zinc finger protein 257 2.12694
STAMBP STAM binding protein 2.1221
CEL carboxyl ester lipase 2.12151
ZNF208 zinc finger protein 208 2.11851
VAT1 vesicle amine transport 1 2.10944
TAC4 tachykinin 4 (hemokinin) 2.10904
TACR3 tachykinin receptor 3 2.09879
IL4R interleukin 4 receptor 2.0915
NOCT nocturnin 2.08094
SKIC2 SKI2 subunit of superkiller complex 2.07149
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.07085
KIFBP kinesin family binding protein 2.06694
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 2.03759
S100A2 S100 calcium binding protein A2 2.02719
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.0255
ANXA10 annexin A10 2.01687
SPRR3 small proline-rich protein 3 2.0152
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.01232
ACOT9 acyl-CoA thioesterase 9 2.00881
MINDY1 MINDY lysine 48 deubiquitinase 1 2.00428

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.46703
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.23602
FGFR4 fibroblast growth factor receptor 4 -5.20122
TLCD3A TLC domain containing 3A -4.93446
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.73461
TRIB3 tribbles pseudokinase 3 -4.43794
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.14031
THAP11 THAP domain containing 11 -4.04941
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.69826
PECR peroxisomal trans-2-enoyl-CoA reductase -3.60353
PLK1 polo-like kinase 1 -3.50757
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.50485
CRELD2 cysteine-rich with EGF-like domains 2 -3.38184
ISOC1 isochorismatase domain containing 1 -3.37719
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.35266
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.27819
GTPBP8 GTP-binding protein 8 (putative) -3.10891
TXLNA taxilin alpha -3.08699
NT5DC2 5'-nucleotidase domain containing 2 -3.03636
DERA deoxyribose-phosphate aldolase (putative) -2.9711
MTERF3 mitochondrial transcription termination factor 3 -2.93788
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.91907
NGRN neugrin, neurite outgrowth associated -2.90033
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.89897
EGF epidermal growth factor -2.8945
MRPS2 mitochondrial ribosomal protein S2 -2.86465
ZMIZ1 zinc finger, MIZ-type containing 1 -2.7825
ALDOC aldolase C, fructose-bisphosphate -2.76588
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.70597
RFC2 replication factor C (activator 1) 2, 40kDa -2.70061
ENOPH1 enolase-phosphatase 1 -2.5868
FASTKD5 FAST kinase domains 5 -2.54923
AURKB aurora kinase B -2.51074
HMG20B high mobility group 20B -2.50489
KIF14 kinesin family member 14 -2.427
NRIP1 nuclear receptor interacting protein 1 -2.41665
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.37641
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.36543
MSMO1 methylsterol monooxygenase 1 -2.3497
SPTSSA serine palmitoyltransferase, small subunit A -2.33616
GNAS GNAS complex locus -2.32293
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.32288
PIMREG PICALM interacting mitotic regulator -2.22135
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.21577
FJX1 four jointed box 1 (Drosophila) -2.20311
MIS12 MIS12 kinetochore complex component -2.15326
FAM8A1 family with sequence similarity 8, member A1 -2.14745
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.14489
SETD6 SET domain containing 6 -2.12936
CCNB1 cyclin B1 -2.05281
SH3D19 SH3 domain containing 19 -2.03964
YME1L1 YME1-like 1 ATPase -2.03909
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.03538
PGM1 phosphoglucomutase 1 -2.02911
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.0058