CRCGN013_HEPG2_24H:M01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isopropanol 42.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN013_HEPG2_24H:M01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.52482
RPL39L ribosomal protein L39-like 5.35925
PROS1 protein S (alpha) 4.87248
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.83583
C2CD2 C2 calcium-dependent domain containing 2 4.53797
MAP7 microtubule-associated protein 7 3.6021
LRP10 low density lipoprotein receptor-related protein 10 3.5841
KIF5C kinesin family member 5C 3.43351
CDC45 cell division cycle 45 3.29689
NUP133 nucleoporin 133kDa 3.12328
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.87492
DIPK1A divergent protein kinase domain 1A 2.79471
FOS FBJ murine osteosarcoma viral oncogene homolog 2.73448
SAC3D1 SAC3 domain containing 1 2.50083
GSTZ1 glutathione S-transferase zeta 1 2.46981
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.36073
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.2699
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.24619
DHCR24 24-dehydrocholesterol reductase 2.17663
PRR7 proline rich 7 (synaptic) 2.05062
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.04733
KMT5B lysine methyltransferase 5B 2.01391

decreased expression

Symbol Name Standardized Value
TNIP1 TNFAIP3 interacting protein 1 -5.87831
NT5DC2 5'-nucleotidase domain containing 2 -5.26048
KDM3A lysine (K)-specific demethylase 3A -4.94933
VAT1 vesicle amine transport 1 -4.78671
ZNF586 zinc finger protein 586 -4.72221
CDC20 cell division cycle 20 -4.34939
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.34811
CCP110 centriolar coiled coil protein 110kDa -4.25765
GNAS GNAS complex locus -3.94873
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.39122
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.2966
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.10867
SLC35F2 solute carrier family 35, member F2 -3.06038
ZMIZ1 zinc finger, MIZ-type containing 1 -2.79033
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.53797
DCK deoxycytidine kinase -2.44618
COG4 component of oligomeric golgi complex 4 -2.44514
CD58 CD58 molecule -2.25379
OXA1L oxidase (cytochrome c) assembly 1-like -2.23291
WDR7 WD repeat domain 7 -2.19281
EGF epidermal growth factor -2.10458
GRB7 growth factor receptor-bound protein 7 -2.08521