CRCGN013_HEPG2_24H:M02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isopropanol 21.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN013_HEPG2_24H:M02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRR15L proline rich 15-like 4.74197
PPARG peroxisome proliferator-activated receptor gamma 4.71416
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.75694
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.4501
CIAO3 cytosolic iron-sulfur assembly component 3 3.1567
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.07962
MCM3 minichromosome maintenance complex component 3 3.00524
GPER1 G protein-coupled estrogen receptor 1 2.91674
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.84898
PIH1D1 PIH1 domain containing 1 2.73424
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.45796
ICAM1 intercellular adhesion molecule 1 2.35358
HSPA1A heat shock 70kDa protein 1A 2.08293
NRN1 neuritin 1 2.08245
GSTZ1 glutathione S-transferase zeta 1 2.07112
TAC1 tachykinin, precursor 1 2.01793

decreased expression

Symbol Name Standardized Value
THAP11 THAP domain containing 11 -6.19242
CDC25B cell division cycle 25B -3.89344
PCNA proliferating cell nuclear antigen -3.89021
HMG20B high mobility group 20B -3.86755
EGF epidermal growth factor -3.73969
LDHD lactate dehydrogenase D -3.70408
MAP7 microtubule-associated protein 7 -3.54597
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.43908
FBXO7 F-box protein 7 -3.43645
GTPBP8 GTP-binding protein 8 (putative) -3.39981
BLCAP bladder cancer associated protein -3.21794
VDAC1 voltage-dependent anion channel 1 -2.99436
NT5DC2 5'-nucleotidase domain containing 2 -2.93386
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.7812
TLCD3A TLC domain containing 3A -2.54717
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.27194
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.23826
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.22338
TXNDC9 thioredoxin domain containing 9 -2.14732