CRCGN013_HEPG2_24H:M06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isopropanol 1.32 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN013_HEPG2_24H:M06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 3.79383
TXNL4B thioredoxin-like 4B 3.70854
ALDOC aldolase C, fructose-bisphosphate 3.69378
TIAM1 T-cell lymphoma invasion and metastasis 1 3.68898
SSBP2 single-stranded DNA binding protein 2 3.50434
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.41594
PRR15L proline rich 15-like 3.25929
PTK2 protein tyrosine kinase 2 3.1932
PPARG peroxisome proliferator-activated receptor gamma 3.13866
ANO10 anoctamin 10 2.8071
NOSIP nitric oxide synthase interacting protein 2.80508
CCNF cyclin F 2.70019
FTO fat mass and obesity associated 2.50243
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.33418
GATA2 GATA binding protein 2 2.31754
GPATCH8 G patch domain containing 8 2.27912
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.14941
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 2.11891
SATB1 SATB homeobox 1 2.05254
MSH3 mutS homolog 3 2.04463

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.34995
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.43657
MAPK13 mitogen-activated protein kinase 13 -6.33828
TUBB6 tubulin, beta 6 class V -5.05678
CCNB2 cyclin B2 -5.01679
DSG2 desmoglein 2 -4.06565
EGF epidermal growth factor -3.86898
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.81731
VAT1 vesicle amine transport 1 -3.73279
PCNA proliferating cell nuclear antigen -3.63299
GNAS GNAS complex locus -3.61993
ADI1 acireductone dioxygenase 1 -3.60805
MRPS2 mitochondrial ribosomal protein S2 -3.27918
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.27521
OXA1L oxidase (cytochrome c) assembly 1-like -3.25254
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.06278
PECR peroxisomal trans-2-enoyl-CoA reductase -3.02124
NUP85 nucleoporin 85kDa -3.007
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.81443
TOR1A torsin family 1, member A (torsin A) -2.4784
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.45415
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.36868
NR0B2 nuclear receptor subfamily 0, group B, member 2 -2.25249
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.15399
ZW10 zw10 kinetochore protein -2.14629
SYNGR4 synaptogyrin 4 -2.13649
TBC1D13 TBC1 domain family, member 13 -2.13007
INO80D INO80 complex subunit D -2.09653
DUSP13A dual specificity phosphatase 13A -2.09278
RGS2 regulator of G-protein signaling 2 -2.05201
USP6NL USP6 N-terminal like -2.04916
KRT37 keratin 37, type I -2.03264
ZMIZ1 zinc finger, MIZ-type containing 1 -2.03083