CRCGN013_HEPG2_24H:M07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dipropylene glycol 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

83 genes differentially expressed following the CRCGN013_HEPG2_24H:M07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 7.80187
E2F2 E2F transcription factor 2 7.00192
PHKG2 phosphorylase kinase, gamma 2 (testis) 5.37505
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.09682
CXCL2 chemokine (C-X-C motif) ligand 2 4.84182
NOTCH1 notch 1 4.68836
CDPF1 cysteine-rich, DPF motif domain containing 1 4.19752
HLA-DMA major histocompatibility complex, class II, DM alpha 4.02094
GPER1 G protein-coupled estrogen receptor 1 3.84396
ADAT1 adenosine deaminase, tRNA-specific 1 3.65678
AMDHD2 amidohydrolase domain containing 2 3.56721
DYNLT3 dynein, light chain, Tctex-type 3 3.28032
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.13551
TBP TATA box binding protein 3.0918
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.96998
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.80378
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.74502
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.69361
ADGRG6 adhesion G protein-coupled receptor G6 2.68967
MCUR1 mitochondrial calcium uniporter regulator 1 2.66298
PRR15L proline rich 15-like 2.65692
CBR3 carbonyl reductase 3 2.64633
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.614
PPARG peroxisome proliferator-activated receptor gamma 2.60165
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.57526
PKN1 protein kinase N1 2.56138
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.51091
HEBP1 heme binding protein 1 2.4305
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.42654
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 2.3771
NUP133 nucleoporin 133kDa 2.34555
ANO1 anoctamin 1, calcium activated chloride channel 2.31417
FBRS fibrosin 2.17565
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.16405
KIF17 kinesin family member 17 2.14608
HSFX2 heat shock transcription factor family, X linked 2 2.14552
HSPA1A heat shock 70kDa protein 1A 2.13304
ISG15 ISG15 ubiquitin-like modifier 2.13164
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.1196
PRELID3A PRELI domain containing 3A 2.113
E2F8 E2F transcription factor 8 2.10333
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 2.09983
PRR13 proline rich 13 2.09083
ADAM10 ADAM metallopeptidase domain 10 2.08873
TBC1D10B TBC1 domain family, member 10B 2.06795
STIMATE STIM activating enhancer 2.05771
RIGI RNA sensor RIG-I 2.05716
RANBP17 RAN binding protein 17 2.03786
FAM120C family with sequence similarity 120C 2.03082
MICB MHC class I polypeptide-related sequence B 2.03024
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.02189
IFI44 interferon-induced protein 44 2.0174
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.00841

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -7.7534
CCNB2 cyclin B2 -5.64523
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -5.08106
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.96173
LDHD lactate dehydrogenase D -4.9164
DERA deoxyribose-phosphate aldolase (putative) -4.58124
DCK deoxycytidine kinase -4.20894
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.39345
CCNB1 cyclin B1 -3.38219
TOMM70 translocase of outer mitochondrial membrane 70 -3.31873
RHEB Ras homolog enriched in brain -3.25048
ZNF586 zinc finger protein 586 -3.08002
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.05275
CAB39 calcium binding protein 39 -2.83112
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.7963
ZW10 zw10 kinetochore protein -2.74576
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.71876
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.56091
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.46846
YME1L1 YME1-like 1 ATPase -2.43204
ELOVL1 ELOVL fatty acid elongase 1 -2.33924
NOP53 NOP53 ribosome biogenesis factor -2.31806
OXA1L oxidase (cytochrome c) assembly 1-like -2.30372
LYZ lysozyme -2.26102
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.13146
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.10464
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.04017
GRWD1 glutamate-rich WD repeat containing 1 -2.0353
DNTT DNA nucleotidylexotransferase -2.03461
REPIN1 replication initiator 1 -2.01397