CRCGN013_HEPG2_24H:M09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dipropylene glycol 10.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN013_HEPG2_24H:M09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ATP11B ATPase, class VI, type 11B 5.21214
BACE2 beta-site APP-cleaving enzyme 2 4.82747
GSTZ1 glutathione S-transferase zeta 1 4.45385
MYLK myosin light chain kinase 4.18967
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.16487
MICALL1 MICAL-like 1 3.13019
FOS FBJ murine osteosarcoma viral oncogene homolog 2.88562
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.72959
ZNF589 zinc finger protein 589 2.72523
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.56413
TBP TATA box binding protein 2.11796
BIRC2 baculoviral IAP repeat containing 2 2.0932
TBXA2R thromboxane A2 receptor 2.08006
PYCR1 pyrroline-5-carboxylate reductase 1 2.07338

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.02912
GOLT1B golgi transport 1B -4.75633
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.4877
DNM1L dynamin 1-like -4.27748
PTPRK protein tyrosine phosphatase, receptor type, K -4.03609
ZNF586 zinc finger protein 586 -3.79041
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.80535
TXNDC9 thioredoxin domain containing 9 -2.45356
GLOD4 glyoxalase domain containing 4 -2.32045
CCNB1 cyclin B1 -2.29499
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.06035