CRCGN013_HEPG2_24H:M10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dipropylene glycol 5.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN013_HEPG2_24H:M10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.8293
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.59072
ADGRE5 adhesion G protein-coupled receptor E5 4.95489
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.8659
CHMP6 charged multivesicular body protein 6 4.55032
CYCS cytochrome c, somatic 4.50845
UBQLN2 ubiquilin 2 4.49436
CEP57 centrosomal protein 57kDa 3.89471
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.63322
MOK MOK protein kinase 3.41454
MAMLD1 mastermind-like domain containing 1 3.26971
RRAGA Ras-related GTP binding A 3.08213
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.00617
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.0048
ZFP36 ZFP36 ring finger protein 2.99322
NOTCH1 notch 1 2.7935
INTS3 integrator complex subunit 3 2.76875
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.75379
GPATCH8 G patch domain containing 8 2.63716
TIMP2 TIMP metallopeptidase inhibitor 2 2.53769
CCNA1 cyclin A1 2.48936
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.47071
ANO1 anoctamin 1, calcium activated chloride channel 2.37744
HYOU1 hypoxia up-regulated 1 2.36718
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.33146
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.28185
EPN2 epsin 2 2.19637
CLDN1 claudin 1 2.14028
FSCN1 fascin actin-bundling protein 1 2.08162
RNF113A ring finger protein 113A 2.06451
ASXL2 additional sex combs like transcriptional regulator 2 2.04108
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 2.02487

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -9.01075
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.88382
GNAS GNAS complex locus -5.42844
VAT1 vesicle amine transport 1 -4.8961
MAPK13 mitogen-activated protein kinase 13 -4.32178
RPS5 ribosomal protein S5 -3.48845
COG2 component of oligomeric golgi complex 2 -3.44902
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.33738
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.19621
ZMIZ1 zinc finger, MIZ-type containing 1 -3.13751
EGF epidermal growth factor -3.12721
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.10499
LDHD lactate dehydrogenase D -3.04797
ANKRD10 ankyrin repeat domain 10 -3.03698
ISOC1 isochorismatase domain containing 1 -2.9842
TCTN1 tectonic family member 1 -2.96754
PCCB propionyl CoA carboxylase, beta polypeptide -2.94237
AKAP8 A kinase (PRKA) anchor protein 8 -2.8543
CAB39 calcium binding protein 39 -2.70758
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.67297
SCAND1 SCAN domain containing 1 -2.5909
PDZD2 PDZ domain containing 2 -2.57598
C2CD5 C2 calcium-dependent domain containing 5 -2.55242
TRIB3 tribbles pseudokinase 3 -2.49464
GDF15 growth differentiation factor 15 -2.40048
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.33611
TXNDC9 thioredoxin domain containing 9 -2.30142
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.29399
MCM6 minichromosome maintenance complex component 6 -2.21311
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -2.21276
GLOD4 glyoxalase domain containing 4 -2.18683
PRELID3A PRELI domain containing 3A -2.17579
DCAF17 DDB1 and CUL4 associated factor 17 -2.14678
PCID2 PCI domain containing 2 -2.14199
NRIP1 nuclear receptor interacting protein 1 -2.12095
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 -2.11491
CCNB1 cyclin B1 -2.11414
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.05644
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -2.03606