CRCGN013_HEPG2_24H:M18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium (e)-4-hydroxy-3-((4-sulfonatonaphthalen-1-yl)diazenyl)naphthalene-1-sulfonate 0.68 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN013_HEPG2_24H:M18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 5.13148
INTS3 integrator complex subunit 3 4.68765
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.64807
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.94314
PEX11A peroxisomal biogenesis factor 11 alpha 3.78399
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.31713
CHN1 chimerin 1 3.23756
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.80474
MINDY1 MINDY lysine 48 deubiquitinase 1 2.62868
PRKCH protein kinase C, eta 2.62101
GPER1 G protein-coupled estrogen receptor 1 2.44206
PPARG peroxisome proliferator-activated receptor gamma 2.34046
SOCS2 suppressor of cytokine signaling 2 2.26085
CEP57 centrosomal protein 57kDa 2.21755
IGFBP3 insulin-like growth factor binding protein 3 2.18014
TBPL1 TBP-like 1 2.15118
LSP1 lymphocyte-specific protein 1 2.03481

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -7.68422
GNAS GNAS complex locus -5.74872
ZDHHC6 zinc finger, DHHC-type containing 6 -4.74799
ZNF586 zinc finger protein 586 -4.74108
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.42619
LDHD lactate dehydrogenase D -4.37535
PLK1 polo-like kinase 1 -4.3351
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.33317
TSPAN4 tetraspanin 4 -3.22474
NRIP1 nuclear receptor interacting protein 1 -2.96938
PCNA proliferating cell nuclear antigen -2.86824
MARCHF5 membrane associated ring-CH-type finger 5 -2.38537
TLCD3A TLC domain containing 3A -2.35891
SNX11 sorting nexin 11 -2.28696
CCNB2 cyclin B2 -2.22875
EIF5 eukaryotic translation initiation factor 5 -2.22518
OXA1L oxidase (cytochrome c) assembly 1-like -2.20352
TLR4 toll-like receptor 4 -2.19687
SSTR2 somatostatin receptor 2 -2.06044
BNC1 basonuclin 1 -2.05922
TMEM259 transmembrane protein 259 -2.01738
DOK2 docking protein 2, 56kDa -2.00061