CRCGN013_HEPG2_24H:M24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diisononyl phthalate 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN013_HEPG2_24H:M24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EVL Enah/Vasp-like 6.59183
LCN2 lipocalin 2 5.34252
BACE2 beta-site APP-cleaving enzyme 2 4.39598
CYCS cytochrome c, somatic 4.16598
CHN1 chimerin 1 4.04601
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.98895
PRR15L proline rich 15-like 3.87407
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.53352
CXCL2 chemokine (C-X-C motif) ligand 2 3.53132
CCDC85B coiled-coil domain containing 85B 3.45265
HLA-DMA major histocompatibility complex, class II, DM alpha 3.41579
PNKP polynucleotide kinase 3'-phosphatase 3.35612
CHMP6 charged multivesicular body protein 6 3.33834
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.07171
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.23924
CCL2 chemokine (C-C motif) ligand 2 2.12427
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.11647
EGF epidermal growth factor 2.0289

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.9101
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.67701
ZNF586 zinc finger protein 586 -5.05104
MRPS2 mitochondrial ribosomal protein S2 -4.7327
PECR peroxisomal trans-2-enoyl-CoA reductase -4.46614
GDF15 growth differentiation factor 15 -3.45925
EIF5 eukaryotic translation initiation factor 5 -3.42747
GNAS GNAS complex locus -3.3873
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.18217
FBXL12 F-box and leucine-rich repeat protein 12 -2.52908
ZNF146 zinc finger protein 146 -2.34567
CAPNS1 calpain, small subunit 1 -2.33183
TM9SF3 transmembrane 9 superfamily member 3 -2.31774
PDCD5 programmed cell death 5 -2.21359
RBM15B RNA binding motif protein 15B -2.06338