CRCGN013_HEPG2_24H:N03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorobenzene 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

75 genes differentially expressed following the CRCGN013_HEPG2_24H:N03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.75787
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.25575
SYNGR3 synaptogyrin 3 4.22975
MINDY1 MINDY lysine 48 deubiquitinase 1 4.08908
NOTCH1 notch 1 3.63643
HDGFL3 HDGF like 3 3.50906
ADGRE5 adhesion G protein-coupled receptor E5 3.45296
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.33485
NENF neudesin neurotrophic factor 3.17523
GPER1 G protein-coupled estrogen receptor 1 3.15294
PRKX protein kinase, X-linked 3.04905
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.0332
HLA-DMA major histocompatibility complex, class II, DM alpha 2.86361
CTSL cathepsin L 2.8526
STIMATE STIM activating enhancer 2.81449
EGF epidermal growth factor 2.55772
MSRA methionine sulfoxide reductase A 2.53857
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.42013
GATA3 GATA binding protein 3 2.40973
PRR15L proline rich 15-like 2.3861
VAV3 vav 3 guanine nucleotide exchange factor 2.38562
CRTAP cartilage associated protein 2.33808
PPARG peroxisome proliferator-activated receptor gamma 2.32005
KDM5A lysine (K)-specific demethylase 5A 2.31166
HOXB5 homeobox B5 2.2307
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.21696
ZNF589 zinc finger protein 589 2.20358
CCR8 chemokine (C-C motif) receptor 8 2.20333
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.19025
AOAH acyloxyacyl hydrolase (neutrophil) 2.17302
PLSCR1 phospholipid scramblase 1 2.16559
MITF microphthalmia-associated transcription factor 2.14157
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.08086
FPR3 formyl peptide receptor 3 2.04224
FGL2 fibrinogen-like 2 2.0035

decreased expression

Symbol Name Standardized Value
ZW10 zw10 kinetochore protein -5.38059
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.01371
NGRN neugrin, neurite outgrowth associated -4.63533
CAB39 calcium binding protein 39 -4.54243
ZDHHC6 zinc finger, DHHC-type containing 6 -3.98698
SMNDC1 survival motor neuron domain containing 1 -3.84092
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.79984
ARID5B AT rich interactive domain 5B (MRF1-like) -3.78525
GOLT1B golgi transport 1B -3.65675
SCAND1 SCAN domain containing 1 -3.62022
FBXL12 F-box and leucine-rich repeat protein 12 -3.612
PECR peroxisomal trans-2-enoyl-CoA reductase -3.22034
C2CD5 C2 calcium-dependent domain containing 5 -3.13983
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.12647
LDHD lactate dehydrogenase D -3.10528
RGS2 regulator of G-protein signaling 2 -3.03836
ADI1 acireductone dioxygenase 1 -2.99986
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.87778
VDAC1 voltage-dependent anion channel 1 -2.72937
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.67231
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.65555
KDM3A lysine (K)-specific demethylase 3A -2.646
SESN1 sestrin 1 -2.57816
CHEK1 checkpoint kinase 1 -2.55044
SLC35F2 solute carrier family 35, member F2 -2.52967
TLCD3A TLC domain containing 3A -2.49597
GNAS GNAS complex locus -2.4867
PCNA proliferating cell nuclear antigen -2.43982
TCTN1 tectonic family member 1 -2.42682
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.37082
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.36093
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.35569
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.28981
GLOD4 glyoxalase domain containing 4 -2.28302
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.21855
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.19715
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.19413
TRIB3 tribbles pseudokinase 3 -2.18207
THRAP3 thyroid hormone receptor associated protein 3 -2.08031
FAIM Fas apoptotic inhibitory molecule -2.03536