CRCGN013_HEPG2_24H:N05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorobenzene 2.48 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN013_HEPG2_24H:N05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.49237
LCN2 lipocalin 2 4.97621
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.84977
SSBP2 single-stranded DNA binding protein 2 3.31319
MTERF3 mitochondrial transcription termination factor 3 3.06099
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 3.01967
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.92815
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.86782
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.30766
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.2749
NPDC1 neural proliferation, differentiation and control, 1 2.10854
PLA2G12A phospholipase A2, group XIIA 2.0703
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.04969
EPHA3 EPH receptor A3 2.04608
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.03767
CYCS cytochrome c, somatic 2.00425

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
LDHD lactate dehydrogenase D -5.26715
OXA1L oxidase (cytochrome c) assembly 1-like -4.85312
GOLT1B golgi transport 1B -4.76995
PCNA proliferating cell nuclear antigen -4.74368
NUP85 nucleoporin 85kDa -4.3428
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.32962
GNAS GNAS complex locus -4.06684
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.9682
MAPK13 mitogen-activated protein kinase 13 -3.55341
FBXO7 F-box protein 7 -3.14194
SLC35F2 solute carrier family 35, member F2 -2.88036
ZNF586 zinc finger protein 586 -2.57493
MAP7 microtubule-associated protein 7 -2.55102
TLR4 toll-like receptor 4 -2.42275
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.37248
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.30514
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 -2.23787
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.22153
TMEM94 transmembrane protein 94 -2.05604
DIAPH1 diaphanous-related formin 1 -2.04168
AKAP11 A kinase (PRKA) anchor protein 11 -2.0357