CRCGN013_HEPG2_24H:N06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorobenzene 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN013_HEPG2_24H:N06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLS1 plastin 1 4.30102
UBQLN2 ubiquilin 2 4.23652
RPP38 ribonuclease P/MRP 38kDa subunit 4.17651
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 3.41339
CHN1 chimerin 1 2.97333
CHMP6 charged multivesicular body protein 6 2.77091
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.75755
ATP11B ATPase, class VI, type 11B 2.68706
NOSIP nitric oxide synthase interacting protein 2.664
HLA-DRA major histocompatibility complex, class II, DR alpha 2.64416
SSBP2 single-stranded DNA binding protein 2 2.52131
VAV3 vav 3 guanine nucleotide exchange factor 2.51386
CUTC cutC copper transporter 2.31579
TCTA T-cell leukemia translocation altered 2.29812
CYB561 cytochrome b561 2.12198
CDK19 cyclin-dependent kinase 19 2.01681

decreased expression

Symbol Name Standardized Value
CHMP4B charged multivesicular body protein 4B -6.96528
FAIM Fas apoptotic inhibitory molecule -5.87739
YME1L1 YME1-like 1 ATPase -5.78196
CCNB2 cyclin B2 -4.51781
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.25638
TLCD3A TLC domain containing 3A -4.14804
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.98588
NT5DC2 5'-nucleotidase domain containing 2 -3.94022
ZNF586 zinc finger protein 586 -3.93231
FASTKD5 FAST kinase domains 5 -3.65212
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.63713
GDF15 growth differentiation factor 15 -3.48594
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.38172
CCDC86 coiled-coil domain containing 86 -3.35263
GNAS GNAS complex locus -3.22948
SCAND1 SCAN domain containing 1 -3.22458
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.20452
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.20111
CD320 CD320 molecule -3.18273
MRPS2 mitochondrial ribosomal protein S2 -3.13262
KDM3A lysine (K)-specific demethylase 3A -3.07885
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.00355
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.87839
GTPBP8 GTP-binding protein 8 (putative) -2.73204
OXA1L oxidase (cytochrome c) assembly 1-like -2.63534
ADI1 acireductone dioxygenase 1 -2.57078
EIF5 eukaryotic translation initiation factor 5 -2.45617
WASHC4 WASH complex subunit 4 -2.42673
RTRAF RNA transcription, translation and transport factor -2.38375
COG2 component of oligomeric golgi complex 2 -2.22739
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.13279