CRCGN013_HEPG2_24H:N07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description glutaraldehyde 38.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

146 genes differentially expressed following the CRCGN013_HEPG2_24H:N07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 7.88578
LRP10 low density lipoprotein receptor-related protein 10 6.65455
CNPY3 canopy FGF signaling regulator 3 6.38592
CTSL cathepsin L 5.75475
LCN2 lipocalin 2 5.18184
MVP major vault protein 4.52411
LSR lipolysis stimulated lipoprotein receptor 4.51269
PRR15L proline rich 15-like 4.38879
CIAO3 cytosolic iron-sulfur assembly component 3 4.31474
H2BC12 H2B clustered histone 12 4.23522
INPP1 inositol polyphosphate-1-phosphatase 3.9002
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.68031
SQOR sulfide quinone oxidoreductase 3.62258
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.59046
STIMATE STIM activating enhancer 3.44587
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.4276
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.42725
INTS3 integrator complex subunit 3 3.2823
ALAS1 5'-aminolevulinate synthase 1 3.27777
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.20589
LYN LYN proto-oncogene, Src family tyrosine kinase 3.20244
MCOLN1 mucolipin 1 3.12443
FAT1 FAT atypical cadherin 1 3.02656
ELAC2 elaC ribonuclease Z 2 3.02367
CYCS cytochrome c, somatic 3.00091
EPHB2 EPH receptor B2 2.99723
SLC35F2 solute carrier family 35, member F2 2.83549
CARMIL1 capping protein regulator and myosin 1 linker 1 2.70363
MMP1 matrix metallopeptidase 1 2.63188
MAP7 microtubule-associated protein 7 2.62433
TBPL1 TBP-like 1 2.62027
MAST2 microtubule associated serine/threonine kinase 2 2.52593
PRKCQ protein kinase C, theta 2.47918
GBA1 glucosylceramidase beta 1 2.47345
CSF3 colony stimulating factor 3 (granulocyte) 2.45636
CDC45 cell division cycle 45 2.42509
H2BC21 H2B clustered histone 21 2.41356
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.33905
MYH4 myosin, heavy chain 4, skeletal muscle 2.25466
FOSL1 FOS-like antigen 1 2.22621
MTX1 metaxin 1 2.19945
TOMM34 translocase of outer mitochondrial membrane 34 2.18444
EPYC epiphycan 2.16954
CD40 CD40 molecule, TNF receptor superfamily member 5 2.16107
H2AC6 H2A clustered histone 6 2.13866
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.13396
FPGS folylpolyglutamate synthase 2.13012
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.11873
GPER1 G protein-coupled estrogen receptor 1 2.10767
SQSTM1 sequestosome 1 2.09154
GHRH growth hormone releasing hormone 2.09127
TIMP2 TIMP metallopeptidase inhibitor 2 2.08855
ABHD4 abhydrolase domain containing 4 2.07809
LAP3 leucine aminopeptidase 3 2.05746
SLC39A1 solute carrier family 39 (zinc transporter), member 1 2.03559
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.03118
VGLL4 vestigial-like family member 4 2.02049
IER3 immediate early response 3 2.01107
TMEM248 transmembrane protein 248 2.005

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.67224
LDHD lactate dehydrogenase D -6.53359
ADI1 acireductone dioxygenase 1 -6.37036
NT5DC2 5'-nucleotidase domain containing 2 -5.39651
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.95721
AURKB aurora kinase B -4.84536
PLK1 polo-like kinase 1 -4.63418
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -4.4329
NUP85 nucleoporin 85kDa -4.40632
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.01624
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.97009
TCTN1 tectonic family member 1 -3.89686
SOAT2 sterol O-acyltransferase 2 -3.83276
PYCR1 pyrroline-5-carboxylate reductase 1 -3.62422
GALE UDP-galactose-4-epimerase -3.56431
PCNA proliferating cell nuclear antigen -3.55868
CCNA2 cyclin A2 -3.47585
ISOC1 isochorismatase domain containing 1 -3.46149
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.38176
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.36909
ALDOC aldolase C, fructose-bisphosphate -3.3396
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.26547
UBE3C ubiquitin protein ligase E3C -3.24936
PECR peroxisomal trans-2-enoyl-CoA reductase -3.21685
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.20318
CCP110 centriolar coiled coil protein 110kDa -3.19345
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.14038
DERA deoxyribose-phosphate aldolase (putative) -3.05103
EVL Enah/Vasp-like -2.9779
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.87984
CCNB2 cyclin B2 -2.87536
UBE2C ubiquitin-conjugating enzyme E2C -2.86241
PHGDH phosphoglycerate dehydrogenase -2.84194
PUF60 poly-U binding splicing factor 60KDa -2.81722
PGM1 phosphoglucomutase 1 -2.78999
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.73173
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.71469
USP6NL USP6 N-terminal like -2.64884
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.64474
PSRC1 proline/serine-rich coiled-coil 1 -2.62282
LBR lamin B receptor -2.61784
C2CD5 C2 calcium-dependent domain containing 5 -2.60914
CNOT8 CCR4-NOT transcription complex, subunit 8 -2.58851
HADH hydroxyacyl-CoA dehydrogenase -2.53743
COG2 component of oligomeric golgi complex 2 -2.5159
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.49153
CDK1 cyclin-dependent kinase 1 -2.45473
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.42933
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -2.41552
ANAPC15 anaphase promoting complex subunit 15 -2.38716
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.38588
CHEK1 checkpoint kinase 1 -2.38492
GTPBP8 GTP-binding protein 8 (putative) -2.38004
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.36197
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.35756
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.34791
STMN1 stathmin 1 -2.33393
NRIP1 nuclear receptor interacting protein 1 -2.33247
S100A4 S100 calcium binding protein A4 -2.30037
BIRC5 baculoviral IAP repeat containing 5 -2.29837
GNAS GNAS complex locus -2.29449
MRPS7 mitochondrial ribosomal protein S7 -2.29276
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -2.29159
DNM1L dynamin 1-like -2.27198
CDK4 cyclin-dependent kinase 4 -2.26961
MELK maternal embryonic leucine zipper kinase -2.2653
MYLK myosin light chain kinase -2.25706
OXSR1 oxidative stress responsive 1 -2.24644
CDC20 cell division cycle 20 -2.21052
BLMH bleomycin hydrolase -2.21037
ASF1B anti-silencing function 1B histone chaperone -2.18804
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.15995
PXMP2 peroxisomal membrane protein 2, 22kDa -2.15327
DDIT4 DNA-damage-inducible transcript 4 -2.13825
RSU1 Ras suppressor protein 1 -2.1141
TMEM120B transmembrane protein 120B -2.11234
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.09126
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.08122
C5 complement component 5 -2.06659
PDF peptide deformylase (mitochondrial) -2.06373
HLA-DMA major histocompatibility complex, class II, DM alpha -2.0519
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.04307
DCK deoxycytidine kinase -2.03196
IFT81 intraflagellar transport 81 -2.01879
EIF5 eukaryotic translation initiation factor 5 -2.01855
LTA4H leukotriene A4 hydrolase -2.01761
PYGL phosphorylase, glycogen, liver -2.01566