CRCGN013_HEPG2_24H:N09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description glutaraldehyde 9.7 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN013_HEPG2_24H:N09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOSIP nitric oxide synthase interacting protein 4.89627
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.32014
MYLK myosin light chain kinase 4.30421
PPARG peroxisome proliferator-activated receptor gamma 4.01764
LYN LYN proto-oncogene, Src family tyrosine kinase 3.95355
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.82148
BACE2 beta-site APP-cleaving enzyme 2 3.80245
GSTZ1 glutathione S-transferase zeta 1 3.51102
PEX11A peroxisomal biogenesis factor 11 alpha 3.15579
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.93233
CHN1 chimerin 1 2.65301
PRR15L proline rich 15-like 2.6181
PFKL phosphofructokinase, liver 2.58837
ANO1 anoctamin 1, calcium activated chloride channel 2.28528
SYNE2 spectrin repeat containing, nuclear envelope 2 2.28229
MARCKSL1 MARCKS-like 1 2.25047
RAB4A RAB4A, member RAS oncogene family 2.18685
UBQLN2 ubiquilin 2 2.04378

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -6.05597
CCNB2 cyclin B2 -5.44915
OXA1L oxidase (cytochrome c) assembly 1-like -5.13678
GNAS GNAS complex locus -4.7074
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.41877
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.7184
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.23149
LDHD lactate dehydrogenase D -3.21077
CAB39 calcium binding protein 39 -2.79577
CISD1 CDGSH iron sulfur domain 1 -2.63209
CDC25B cell division cycle 25B -2.50573
EIF5 eukaryotic translation initiation factor 5 -2.46775
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.43408
LPIN1 lipin 1 -2.08673
DDIT4 DNA-damage-inducible transcript 4 -2.04174
YME1L1 YME1-like 1 ATPase -2.03148