CRCGN013_HEPG2_24H:N11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description glutaraldehyde 2.42 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN013_HEPG2_24H:N11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 9.03432
SRC SRC proto-oncogene, non-receptor tyrosine kinase 5.62706
CIAO3 cytosolic iron-sulfur assembly component 3 4.44658
RPP38 ribonuclease P/MRP 38kDa subunit 4.2864
CARMIL1 capping protein regulator and myosin 1 linker 1 4.2327
PROS1 protein S (alpha) 3.95606
MYLK myosin light chain kinase 3.91062
SSBP2 single-stranded DNA binding protein 2 3.87527
LCN2 lipocalin 2 3.86574
HLA-DRA major histocompatibility complex, class II, DR alpha 3.81756
CHMP6 charged multivesicular body protein 6 3.43965
KLHL9 kelch-like family member 9 3.27266
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.25559
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.2146
GPER1 G protein-coupled estrogen receptor 1 3.03591
EPHA3 EPH receptor A3 2.91756
CD40 CD40 molecule, TNF receptor superfamily member 5 2.86919
LRP10 low density lipoprotein receptor-related protein 10 2.82819
EGF epidermal growth factor 2.75613
H2BC12 H2B clustered histone 12 2.74116
RAB21 RAB21, member RAS oncogene family 2.66852
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.43958
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.3953
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.36067
MAP7 microtubule-associated protein 7 2.34188
SNX7 sorting nexin 7 2.33309
MSTN myostatin 2.27141
CXCL9 chemokine (C-X-C motif) ligand 9 2.13005
ZNF140 zinc finger protein 140 2.11433
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.11343
PRDM13 PR domain containing 13 2.06653
QSER1 glutamine and serine rich 1 2.03447

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
TLCD3A TLC domain containing 3A -6.73466
NUP85 nucleoporin 85kDa -5.80115
LDHD lactate dehydrogenase D -5.72766
PCNA proliferating cell nuclear antigen -5.52743
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.42319
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.10653
CCNB2 cyclin B2 -4.67061
GNAS GNAS complex locus -3.62233
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.49136
FAIM Fas apoptotic inhibitory molecule -3.30275
SLC35F2 solute carrier family 35, member F2 -3.08426
OXA1L oxidase (cytochrome c) assembly 1-like -3.05491
IFRD2 interferon-related developmental regulator 2 -2.98186
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.72375
DPP3 dipeptidyl-peptidase 3 -2.43012
CCP110 centriolar coiled coil protein 110kDa -2.41764
KCTD2 potassium channel tetramerization domain containing 2 -2.40384
GLOD4 glyoxalase domain containing 4 -2.34697
JPT1 Jupiter microtubule associated homolog 1 -2.22062
CAB39 calcium binding protein 39 -2.21208
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.1979
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.18636
SCAND1 SCAN domain containing 1 -2.17652
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.13672
TPGS1 tubulin polyglutamylase complex subunit 1 -2.12825
ARMC1 armadillo repeat containing 1 -2.10161
CRYZ crystallin, zeta (quinone reductase) -2.08198
COL9A1 collagen, type IX, alpha 1 -2.06208
THBS4 thrombospondin 4 -2.04425
ARID5B AT rich interactive domain 5B (MRF1-like) -2.01604