CRCGN013_HEPG2_24H:N16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vorinostat 2.67 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

469 genes differentially expressed following the CRCGN013_HEPG2_24H:N16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBE2L6 ubiquitin-conjugating enzyme E2L 6 10.0
FOXO4 forkhead box O4 9.34125
ALDOC aldolase C, fructose-bisphosphate 9.15986
CBR1 carbonyl reductase 1 8.96838
DNM1 dynamin 1 8.90718
CDPF1 cysteine-rich, DPF motif domain containing 1 6.38682
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 6.30918
HMG20B high mobility group 20B 5.83499
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 5.78968
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 5.74259
NPDC1 neural proliferation, differentiation and control, 1 5.70507
MYC v-myc avian myelocytomatosis viral oncogene homolog 5.66221
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 5.58771
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.38213
STX1A syntaxin 1A (brain) 5.37946
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 5.3059
H2BC12 H2B clustered histone 12 5.15921
TCEA2 transcription elongation factor A (SII), 2 5.09131
STXBP1 syntaxin binding protein 1 5.08142
SKIC2 SKI2 subunit of superkiller complex 4.81261
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 4.73862
ABHD6 abhydrolase domain containing 6 4.69639
ANO10 anoctamin 10 4.55942
MVP major vault protein 4.55054
DUSP6 dual specificity phosphatase 6 4.48481
PLA2G15 phospholipase A2, group XV 4.43346
PRKCD protein kinase C, delta 4.06011
TAC4 tachykinin 4 (hemokinin) 4.03513
ARFIP2 ADP-ribosylation factor interacting protein 2 3.90706
TMEM50A transmembrane protein 50A 3.84726
AMDHD2 amidohydrolase domain containing 2 3.83802
TIMP2 TIMP metallopeptidase inhibitor 2 3.78563
LGMN legumain 3.7814
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.71476
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.6653
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 3.65731
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 3.57718
LRP10 low density lipoprotein receptor-related protein 10 3.54175
CARMIL1 capping protein regulator and myosin 1 linker 1 3.47041
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.46619
TXNL4B thioredoxin-like 4B 3.45978
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.44611
NFIL3 nuclear factor, interleukin 3 regulated 3.40029
PTPN12 protein tyrosine phosphatase, non-receptor type 12 3.39695
VAT1 vesicle amine transport 1 3.32239
CNPY4 canopy FGF signaling regulator 4 3.27394
ZDHHC6 zinc finger, DHHC-type containing 6 3.26189
SCYL3 SCY1-like 3 (S. cerevisiae) 3.2387
BACE2 beta-site APP-cleaving enzyme 2 3.1976
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.19683
DOK4 docking protein 4 3.18742
IER3 immediate early response 3 3.16145
USP6NL USP6 N-terminal like 3.15999
ZBTB22 zinc finger and BTB domain containing 22 3.14174
TRAPPC6A trafficking protein particle complex 6A 3.1296
GPR162 G protein-coupled receptor 162 3.07315
CCND3 cyclin D3 3.07104
SMAD3 SMAD family member 3 3.04513
KIF5C kinesin family member 5C 3.04404
GOLGB1 golgin B1 3.01218
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 3.00673
IGF1R insulin-like growth factor 1 receptor 3.00152
CGRRF1 cell growth regulator with ring finger domain 1 2.99951
COG7 component of oligomeric golgi complex 7 2.97143
MXI1 MAX interactor 1, dimerization protein 2.92229
PECR peroxisomal trans-2-enoyl-CoA reductase 2.91321
UBQLN2 ubiquilin 2 2.90975
MAST2 microtubule associated serine/threonine kinase 2 2.9012
RUSC2 RUN and SH3 domain containing 2 2.87669
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.86636
RTN2 reticulon 2 2.84719
SDK2 sidekick cell adhesion molecule 2 2.83574
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.82951
LSR lipolysis stimulated lipoprotein receptor 2.80541
MAPK3 mitogen-activated protein kinase 3 2.79589
ZMIZ1 zinc finger, MIZ-type containing 1 2.78205
BMP4 bone morphogenetic protein 4 2.76398
CALM3 calmodulin 3 (phosphorylase kinase, delta) 2.76172
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.74945
UNC93B1 unc-93 homolog B1 (C. elegans) 2.72819
TXNRD1 thioredoxin reductase 1 2.71804
SFXN3 sideroflexin 3 2.71518
HMOX1 heme oxygenase 1 2.71372
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.71078
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.71047
INTS3 integrator complex subunit 3 2.69571
ABHD4 abhydrolase domain containing 4 2.68636
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.66436
PTMS parathymosin 2.61412
PRCP prolylcarboxypeptidase (angiotensinase C) 2.59572
UGDH UDP-glucose 6-dehydrogenase 2.59426
FABP2 fatty acid binding protein 2, intestinal 2.58408
LOC127933115 uncharacterized LOC127933115 2.55342
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.54582
MEGF8 multiple EGF-like-domains 8 2.5435
DENND2D DENN/MADD domain containing 2D 2.54322
TWF2 twinfilin actin binding protein 2 2.53741
FAT1 FAT atypical cadherin 1 2.53581
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.53071
TLE6 transducin-like enhancer of split 6 2.52758
KDM5A lysine (K)-specific demethylase 5A 2.5218
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 2.48137
RBKS ribokinase 2.47264
TBC1D10C TBC1 domain family, member 10C 2.47183
CEMIP2 cell migration inducing hyaluronidase 2 2.47148
CELF3 CUGBP, Elav-like family member 3 2.46542
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.45282
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.44786
PDLIM1 PDZ and LIM domain 1 2.43547
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.42524
DPF1 D4, zinc and double PHD fingers family 1 2.4241
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.41288
GRN granulin 2.40933
CTSB cathepsin B 2.40905
INPP1 inositol polyphosphate-1-phosphatase 2.40513
ADAP1 ArfGAP with dual PH domains 1 2.40394
CTSC cathepsin C 2.39826
ERCC1 excision repair cross-complementation group 1 2.39572
NCOA3 nuclear receptor coactivator 3 2.39159
SLC67A1 solute carrier family 67 member 1 2.38982
ZNF646 zinc finger protein 646 2.3827
SCGB1D1 secretoglobin, family 1D, member 1 2.37902
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 2.3675
RAB4A RAB4A, member RAS oncogene family 2.36604
FRMD4B FERM domain containing 4B 2.36577
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.3599
TBXA2R thromboxane A2 receptor 2.34366
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 2.33778
NIT1 nitrilase 1 2.33216
NME7 NME/NM23 family member 7 2.3312
TGFB3 transforming growth factor, beta 3 2.30904
SEPHS2 selenophosphate synthetase 2 2.30864
NOTCH1 notch 1 2.30806
CCDC71 coiled-coil domain containing 71 2.30756
PLK3 polo-like kinase 3 2.30278
TCF15 transcription factor 15 (basic helix-loop-helix) 2.29337
GPR137B G protein-coupled receptor 137B 2.29273
FBXO2 F-box protein 2 2.29192
CCL3L3 chemokine (C-C motif) ligand 3-like 3 2.29164
GRK5 G protein-coupled receptor kinase 5 2.29034
DPH2 DPH2 homolog (S. cerevisiae) 2.28752
NT5DC3 5'-nucleotidase domain containing 3 2.28599
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.2804
BBC3 BCL2 binding component 3 2.279
SPI1 Spi-1 proto-oncogene 2.27179
EPN2 epsin 2 2.26901
INKA2 inka box actin regulator 2 2.26391
SYT12 synaptotagmin XII 2.25012
PFKP phosphofructokinase, platelet 2.24634
WDR47 WD repeat domain 47 2.2437
OCEL1 occludin/ELL domain containing 1 2.23735
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 2.22868
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.22429
DDB2 damage-specific DNA binding protein 2, 48kDa 2.22003
KATNIP katanin interacting protein 2.21764
AHR aryl hydrocarbon receptor 2.21706
ADGRD2 adhesion G protein-coupled receptor D2 2.21442
GLRX glutaredoxin (thioltransferase) 2.21309
NACAD NAC alpha domain containing 2.21207
GNS glucosamine (N-acetyl)-6-sulfatase 2.20689
CREB3L2 cAMP responsive element binding protein 3-like 2 2.20458
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 2.20099
TWNK twinkle mtDNA helicase 2.20054
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.19951
DYNC2I1 dynein 2 intermediate chain 1 2.19143
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.191
NDRG1 N-myc downstream regulated 1 2.18585
TDRD7 tudor domain containing 7 2.18443
S100A11 S100 calcium binding protein A11 2.17787
PLPPR2 phospholipid phosphatase related 2 2.17754
ZFC3H1 zinc finger, C3H1-type containing 2.16947
PHF1 PHD finger protein 1 2.16903
FABP3 fatty acid binding protein 3, muscle and heart 2.16617
GMPPA GDP-mannose pyrophosphorylase A 2.16474
CST4 cystatin S 2.15909
TERF2IP telomeric repeat binding factor 2, interacting protein 2.15783
CTSD cathepsin D 2.15637
AMPD2 adenosine monophosphate deaminase 2 2.15463
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.1533
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 2.1529
ZNG1A Zn regulated GTPase metalloprotein activator 1A 2.15066
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.14199
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.13641
RRAS related RAS viral (r-ras) oncogene homolog 2.13141
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 2.12444
ARL3 ADP-ribosylation factor-like 3 2.119
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.11745
ROM1 retinal outer segment membrane protein 1 2.10961
H2AC6 H2A clustered histone 6 2.10861
CATSPERH catsper channel auxiliary subunit eta 2.10729
HOXB3 homeobox B3 2.10559
MARK4 MAP/microtubule affinity-regulating kinase 4 2.10145
FCHO1 FCH domain only 1 2.09582
SSBP2 single-stranded DNA binding protein 2 2.09437
HSF4 heat shock transcription factor 4 2.09046
ASIC1 acid sensing (proton gated) ion channel 1 2.08993
IRS1 insulin receptor substrate 1 2.08989
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.08884
THSD7A thrombospondin, type I, domain containing 7A 2.08836
SPEG SPEG complex locus 2.08714
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.08507
HABP4 hyaluronan binding protein 4 2.08482
EBNA1BP2 EBNA1 binding protein 2 2.0822
ADAM10 ADAM metallopeptidase domain 10 2.07929
CCL14 chemokine (C-C motif) ligand 14 2.07853
REEP2 receptor accessory protein 2 2.07654
RABAC1 Rab acceptor 1 (prenylated) 2.07454
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.07396
PPP1R16B protein phosphatase 1, regulatory subunit 16B 2.07328
HOOK2 hook microtubule-tethering protein 2 2.07247
IGSF3 immunoglobulin superfamily, member 3 2.06771
SSTR3 somatostatin receptor 3 2.06283
LPXN leupaxin 2.06208
RAB21 RAB21, member RAS oncogene family 2.05906
RUVBL1 RuvB-like AAA ATPase 1 2.05468
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.04516
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 2.04514
PLCH2 phospholipase C, eta 2 2.03949
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 2.03889
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 2.03501
SSH3 slingshot protein phosphatase 3 2.0337
AMN amnion associated transmembrane protein 2.02875
KIRREL1 kirre like nephrin family adhesion molecule 1 2.02273
VSX1 visual system homeobox 1 2.01521
IQCC IQ motif containing C 2.0142
TBC1D15 TBC1 domain family, member 15 2.0116
CALU calumenin 2.00987
TMCO1 transmembrane and coiled-coil domains 1 2.00774
AARS1 alanyl-tRNA synthetase 1 2.00631

decreased expression

Symbol Name Standardized Value
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -8.54333
TLCD3A TLC domain containing 3A -7.35771
ADI1 acireductone dioxygenase 1 -7.30792
CD320 CD320 molecule -7.25238
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -7.19287
UBE2C ubiquitin-conjugating enzyme E2C -6.76086
LDHD lactate dehydrogenase D -6.33079
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.8308
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -5.79112
CDK1 cyclin-dependent kinase 1 -5.65274
CRELD2 cysteine-rich with EGF-like domains 2 -5.62713
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.5397
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.53864
PCCB propionyl CoA carboxylase, beta polypeptide -5.50783
STAP2 signal transducing adaptor family member 2 -5.37731
CCNA2 cyclin A2 -5.37154
RFC2 replication factor C (activator 1) 2, 40kDa -5.3424
PGM1 phosphoglucomutase 1 -5.33978
ICAM3 intercellular adhesion molecule 3 -5.23869
KEAP1 kelch-like ECH-associated protein 1 -5.21498
TATDN2 TatD DNase domain containing 2 -5.15494
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.95722
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -4.82049
RPIA ribose 5-phosphate isomerase A -4.72432
TCERG1 transcription elongation regulator 1 -4.64754
ATF5 activating transcription factor 5 -4.5928
SPAG7 sperm associated antigen 7 -4.50914
DERA deoxyribose-phosphate aldolase (putative) -4.3846
TCTN1 tectonic family member 1 -4.3684
TMEM109 transmembrane protein 109 -4.27916
LOC124907782 dual specificity protein phosphatase 22 -4.24667
WDR7 WD repeat domain 7 -4.23329
MELK maternal embryonic leucine zipper kinase -4.21635
FBXO7 F-box protein 7 -4.18564
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.16715
NUP85 nucleoporin 85kDa -4.16419
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -4.16344
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -4.14229
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.08799
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.08346
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.94434
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.92226
AURKB aurora kinase B -3.85661
GLOD4 glyoxalase domain containing 4 -3.83242
GTPBP8 GTP-binding protein 8 (putative) -3.76836
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.75971
POLE polymerase (DNA directed), epsilon, catalytic subunit -3.71947
PLK1 polo-like kinase 1 -3.70116
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.63673
SOAT2 sterol O-acyltransferase 2 -3.6307
RCC1L RCC1 like -3.61764
FOSL1 FOS-like antigen 1 -3.59065
TRIB3 tribbles pseudokinase 3 -3.48792
TOR1A torsin family 1, member A (torsin A) -3.48087
CCNB2 cyclin B2 -3.42348
MCM5 minichromosome maintenance complex component 5 -3.40673
LRRC41 leucine rich repeat containing 41 -3.34948
ECH1 enoyl CoA hydratase 1, peroxisomal -3.32581
PSAT1 phosphoserine aminotransferase 1 -3.3173
PHF2 PHD finger protein 2 -3.30517
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.29139
NNT nicotinamide nucleotide transhydrogenase -3.28917
CDC25A cell division cycle 25A -3.28074
PROS1 protein S (alpha) -3.25663
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.25391
CASC3 cancer susceptibility candidate 3 -3.24178
CHEK1 checkpoint kinase 1 -3.23003
DCTD dCMP deaminase -3.22661
USP39 ubiquitin specific peptidase 39 -3.21793
CDK4 cyclin-dependent kinase 4 -3.20039
ZNF586 zinc finger protein 586 -3.15893
POLR1A polymerase (RNA) I polypeptide A, 194kDa -3.14217
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -3.13952
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.08626
TXNDC9 thioredoxin domain containing 9 -3.03968
GNAS GNAS complex locus -3.00308
GALE UDP-galactose-4-epimerase -2.96345
ANAPC1 anaphase promoting complex subunit 1 -2.91659
MSRA methionine sulfoxide reductase A -2.90072
CDT1 chromatin licensing and DNA replication factor 1 -2.89031
ANKRD10 ankyrin repeat domain 10 -2.8887
FANCG Fanconi anemia, complementation group G -2.87109
ATMIN ATM interactor -2.86724
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.86512
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.85803
MAP7 microtubule-associated protein 7 -2.83631
BCL7B B-cell CLL/lymphoma 7B -2.8305
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.82736
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 -2.82473
NCAPH non-SMC condensin I complex, subunit H -2.81056
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.80798
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.80459
KRCC1 lysine-rich coiled-coil 1 -2.80126
TACC3 transforming, acidic coiled-coil containing protein 3 -2.78918
FOXM1 forkhead box M1 -2.77359
CDC20 cell division cycle 20 -2.77143
ITGB5 integrin, beta 5 -2.76001
THOC1 THO complex 1 -2.74809
DCK deoxycytidine kinase -2.74439
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.72158
C5 complement component 5 -2.69726
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.68795
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.6836
CLUH clustered mitochondria (cluA/CLU1) homolog -2.65416
TPM1 tropomyosin 1 (alpha) -2.64049
RPH3AL rabphilin 3A-like (without C2 domains) -2.63121
CCDC86 coiled-coil domain containing 86 -2.6049
SLC35B1 solute carrier family 35, member B1 -2.59483
FAIM Fas apoptotic inhibitory molecule -2.56743
BIRC5 baculoviral IAP repeat containing 5 -2.56603
MRM3 mitochondrial rRNA methyltransferase 3 -2.56331
VRK2 vaccinia related kinase 2 -2.56324
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.55823
HJURP Holliday junction recognition protein -2.55351
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.55101
KIF4A kinesin family member 4A -2.53532
CDC6 cell division cycle 6 -2.53277
MRPS16 mitochondrial ribosomal protein S16 -2.52733
MCM7 minichromosome maintenance complex component 7 -2.52733
ASF1B anti-silencing function 1B histone chaperone -2.52319
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -2.51182
CPNE3 copine III -2.50364
MRPS2 mitochondrial ribosomal protein S2 -2.49457
OXA1L oxidase (cytochrome c) assembly 1-like -2.49451
USP1 ubiquitin specific peptidase 1 -2.48668
PTPN3 protein tyrosine phosphatase, non-receptor type 3 -2.48634
OIP5 Opa interacting protein 5 -2.47994
RBM14-RBM4 RBM14-RBM4 readthrough -2.47944
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.46258
NDC80 NDC80 kinetochore complex component -2.46031
SPAG4 sperm associated antigen 4 -2.44208
ATP9B ATPase, class II, type 9B -2.43969
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -2.43725
NCK2 NCK adaptor protein 2 -2.43081
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.42061
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -2.41437
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.40752
MTA1 metastasis associated 1 -2.39477
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.38725
C2CD2 C2 calcium-dependent domain containing 2 -2.38492
MYO19 myosin XIX -2.38413
CHPT1 choline phosphotransferase 1 -2.38234
KLHL21 kelch-like family member 21 -2.37968
FXYD3 FXYD domain containing ion transport regulator 3 -2.36264
TTK TTK protein kinase -2.36007
EXOSC8 exosome component 8 -2.34984
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.34688
EIF5 eukaryotic translation initiation factor 5 -2.3464
CDCA8 cell division cycle associated 8 -2.33953
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.3253
DCAF17 DDB1 and CUL4 associated factor 17 -2.31301
TRAF1 TNF receptor-associated factor 1 -2.31129
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -2.30927
EGF epidermal growth factor -2.30679
ACOD1 aconitate decarboxylase 1 -2.30492
HMGA2 high mobility group AT-hook 2 -2.30137
MRPL39 mitochondrial ribosomal protein L39 -2.29018
NUP62 nucleoporin 62kDa -2.28907
ACYP2 acylphosphatase 2, muscle type -2.28136
ZW10 zw10 kinetochore protein -2.28124
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -2.27897
ARID5B AT rich interactive domain 5B (MRF1-like) -2.27773
KIF15 kinesin family member 15 -2.27196
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.26525
SAYSD1 SAYSVFN motif domain containing 1 -2.26484
NUP43 nucleoporin 43kDa -2.26103
HMGN3 high mobility group nucleosomal binding domain 3 -2.25831
ISOC1 isochorismatase domain containing 1 -2.25458
PADI2 peptidyl arginine deiminase, type II -2.23963
AEBP1 AE binding protein 1 -2.23721
TERT telomerase reverse transcriptase -2.23156
SRD5A3 steroid 5 alpha-reductase 3 -2.22532
CAPN15 calpain 15 -2.222
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.2086
LMNB1 lamin B1 -2.20499
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.2016
SMAP1 small ArfGAP 1 -2.19582
APOBEC3A_B APOBEC3A and APOBEC3B deletion hybrid -2.18833
EXT1 exostosin glycosyltransferase 1 -2.18781
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.18583
NAP1L4 nucleosome assembly protein 1-like 4 -2.18255
TTC19 tetratricopeptide repeat domain 19 -2.17679
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.17463
ZBTB24 zinc finger and BTB domain containing 24 -2.16774
ZBTB35 zinc finger and BTB domain containing 35 -2.16662
VBP1 von Hippel-Lindau binding protein 1 -2.1629
LYRM1 LYR motif containing 1 -2.15347
WDR70 WD repeat domain 70 -2.14995
ICE2 interactor of little elongation complex ELL subunit 2 -2.14667
ARF5 ADP-ribosylation factor 5 -2.14521
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -2.14327
IRAK4 interleukin-1 receptor-associated kinase 4 -2.14246
DEPDC1 DEP domain containing 1 -2.13923
MCM10 minichromosome maintenance complex component 10 -2.12868
KIF14 kinesin family member 14 -2.12741
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -2.12646
FAHD2A fumarylacetoacetate hydrolase domain containing 2A -2.12185
PTCD3 pentatricopeptide repeat domain 3 -2.1157
SERTAD2 SERTA domain containing 2 -2.11284
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.11262
MED24 mediator complex subunit 24 -2.11096
LRRC15 leucine rich repeat containing 15 -2.10979
AP4M1 adaptor-related protein complex 4, mu 1 subunit -2.10871
KIF18B kinesin family member 18B -2.10408
RFWD3 ring finger and WD repeat domain 3 -2.10373
MYLK myosin light chain kinase -2.10304
VCAM1 vascular cell adhesion molecule 1 -2.09484
CCNE1 cyclin E1 -2.09398
STX17 syntaxin 17 -2.09367
RFC3 replication factor C (activator 1) 3, 38kDa -2.09246
VRK1 vaccinia related kinase 1 -2.092
CEP192 centrosomal protein 192kDa -2.08973
MTO1 mitochondrial tRNA translation optimization 1 -2.08862
NUP88 nucleoporin 88kDa -2.07263
RMI1 RecQ mediated genome instability 1 -2.06452
NGRN neugrin, neurite outgrowth associated -2.06045
KRI1 KRI1 homolog (S. cerevisiae) -2.06037
MAEA macrophage erythroblast attacher -2.05754
SQOR sulfide quinone oxidoreductase -2.05708
TMEM97 transmembrane protein 97 -2.05562
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B -2.05507
CDK12 cyclin-dependent kinase 12 -2.05475
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.05159
TRIP13 thyroid hormone receptor interactor 13 -2.04188
IDE insulin-degrading enzyme -2.04048
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.03586
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z -2.02758
EDDM3B epididymal protein 3B -2.0252
LIPT1 lipoyltransferase 1 -2.01575
GEMIN4 gem (nuclear organelle) associated protein 4 -2.01565
CD207 CD207 molecule, langerin -2.01253
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -2.01168
FXN frataxin -2.00847
POLK polymerase (DNA directed) kappa -2.00778
ENOSF1 enolase superfamily member 1 -2.0077
URM1 ubiquitin related modifier 1 -2.00505
ZNF273 zinc finger protein 273 -2.00414
CASD1 CAS1 domain containing 1 -2.00238
BANP BTG3 associated nuclear protein -2.00218
METTL4 methyltransferase like 4 -2.00008