| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | vorinostat 1.33 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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285 genes differentially expressed following the CRCGN013_HEPG2_24H:N17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 9.43666 |
| CBR1 | carbonyl reductase 1 | 8.1485 |
| DNM1 | dynamin 1 | 6.32147 |
| FOXO4 | forkhead box O4 | 6.14017 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 5.38817 |
| PRR15L | proline rich 15-like | 5.35587 |
| PLS1 | plastin 1 | 5.30853 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 5.18862 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 5.00097 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 4.92882 |
| STXBP1 | syntaxin binding protein 1 | 4.86024 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 4.72447 |
| MVP | major vault protein | 4.63697 |
| USP6NL | USP6 N-terminal like | 4.54553 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 4.51433 |
| HMG20B | high mobility group 20B | 4.49447 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 4.42791 |
| TCEA2 | transcription elongation factor A (SII), 2 | 4.2031 |
| DENND2D | DENN/MADD domain containing 2D | 4.18019 |
| SKIC2 | SKI2 subunit of superkiller complex | 4.13327 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 3.99285 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 3.94313 |
| STK10 | serine/threonine kinase 10 | 3.85383 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.84394 |
| CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta | 3.80801 |
| E2F2 | E2F transcription factor 2 | 3.74674 |
| ALDOC | aldolase C, fructose-bisphosphate | 3.66917 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 3.66311 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 3.4766 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 3.22985 |
| CYCS | cytochrome c, somatic | 3.21843 |
| ABHD4 | abhydrolase domain containing 4 | 3.13168 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.12733 |
| DUSP6 | dual specificity phosphatase 6 | 3.10911 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 3.08589 |
| PLA2G15 | phospholipase A2, group XV | 3.06053 |
| PRCP | prolylcarboxypeptidase (angiotensinase C) | 3.03409 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 2.99632 |
| COG7 | component of oligomeric golgi complex 7 | 2.9697 |
| CDK6 | cyclin-dependent kinase 6 | 2.93068 |
| DDR1 | discoidin domain receptor tyrosine kinase 1 | 2.92933 |
| BAMBI | BMP and activin membrane-bound inhibitor | 2.85931 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 2.85856 |
| CTSL | cathepsin L | 2.83907 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 2.81711 |
| MAPK3 | mitogen-activated protein kinase 3 | 2.79066 |
| ARFIP2 | ADP-ribosylation factor interacting protein 2 | 2.76472 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 2.71243 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 2.67163 |
| TUBB6 | tubulin, beta 6 class V | 2.66163 |
| AARS1 | alanyl-tRNA synthetase 1 | 2.65998 |
| TWF2 | twinfilin actin binding protein 2 | 2.65527 |
| BMP4 | bone morphogenetic protein 4 | 2.59887 |
| CHMP6 | charged multivesicular body protein 6 | 2.5688 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | 2.56746 |
| XPO7 | exportin 7 | 2.5607 |
| TMEM50A | transmembrane protein 50A | 2.54052 |
| COPS7A | COP9 signalosome subunit 7A | 2.51843 |
| AMPD2 | adenosine monophosphate deaminase 2 | 2.51024 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | 2.5032 |
| ATF6 | activating transcription factor 6 | 2.46602 |
| IGSF3 | immunoglobulin superfamily, member 3 | 2.42733 |
| SDK2 | sidekick cell adhesion molecule 2 | 2.42256 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 2.41116 |
| SHC2 | SHC (Src homology 2 domain containing) transforming protein 2 | 2.40598 |
| RTN2 | reticulon 2 | 2.40193 |
| REG1A | regenerating islet-derived 1 alpha | 2.38387 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 2.38326 |
| GJA4 | gap junction protein, alpha 4, 37kDa | 2.38304 |
| H2BC12 | H2B clustered histone 12 | 2.37828 |
| KIAA0319L | KIAA0319-like | 2.37629 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 2.35368 |
| NELL1 | NEL-like 1 (chicken) | 2.34793 |
| CLSTN3 | calsyntenin 3 | 2.34209 |
| DNAAF3 | dynein, axonemal, assembly factor 3 | 2.33395 |
| TRIM45 | tripartite motif containing 45 | 2.33098 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 2.32909 |
| ROM1 | retinal outer segment membrane protein 1 | 2.31718 |
| SCGB1D1 | secretoglobin, family 1D, member 1 | 2.31321 |
| FAT1 | FAT atypical cadherin 1 | 2.30946 |
| PTK2 | protein tyrosine kinase 2 | 2.30688 |
| ANO10 | anoctamin 10 | 2.30683 |
| MOK | MOK protein kinase | 2.28525 |
| STON1 | stonin 1 | 2.28407 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 2.27704 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 2.25917 |
| SLC35H1 | solute carrier family 35 member H1 | 2.25696 |
| TARS2 | threonyl-tRNA synthetase 2, mitochondrial (putative) | 2.25353 |
| TXNRD1 | thioredoxin reductase 1 | 2.25003 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 2.24064 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | 2.2247 |
| GPR137B | G protein-coupled receptor 137B | 2.22353 |
| TLE6 | transducin-like enhancer of split 6 | 2.21962 |
| DAG1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) | 2.21 |
| DOK4 | docking protein 4 | 2.20951 |
| SORCS3 | sortilin-related VPS10 domain containing receptor 3 | 2.20525 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) | 2.20023 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 2.19766 |
| BCKDK | branched chain ketoacid dehydrogenase kinase | 2.19617 |
| TMEM74B | transmembrane protein 74B | 2.18491 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | 2.1557 |
| TGFB3 | transforming growth factor, beta 3 | 2.15483 |
| TRAPPC6A | trafficking protein particle complex 6A | 2.14992 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.1363 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.13352 |
| REEP2 | receptor accessory protein 2 | 2.13096 |
| PDLIM1 | PDZ and LIM domain 1 | 2.13053 |
| NECTIN2 | nectin cell adhesion molecule 2 | 2.12607 |
| RHOC | ras homolog family member C | 2.12575 |
| LGMN | legumain | 2.12366 |
| FSTL1 | follistatin-like 1 | 2.11471 |
| SYNGR3 | synaptogyrin 3 | 2.09232 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | 2.09129 |
| SLC5A1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 | 2.08569 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 2.08341 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | 2.07933 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 2.07651 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 2.05888 |
| EPS8L1 | EPS8-like 1 | 2.05256 |
| IL10RB | interleukin 10 receptor, beta | 2.04278 |
| LOC124906280 | uncharacterized LOC124906280 | 2.04098 |
| STIMATE | STIM activating enhancer | 2.03861 |
| VASH1 | vasohibin 1 | 2.03453 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | 2.03443 |
| SPI1 | Spi-1 proto-oncogene | 2.03338 |
| NEU2 | sialidase 2 (cytosolic sialidase) | 2.03127 |
| CCDC71 | coiled-coil domain containing 71 | 2.03095 |
| MMP2 | matrix metallopeptidase 2 | 2.02349 |
| ZFC3H1 | zinc finger, C3H1-type containing | 2.02221 |
| SEMA4F | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F | 2.02025 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 2.01638 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 2.01201 |
| RBKS | ribokinase | 2.00975 |
| MTMR11 | myotubularin related protein 11 | 2.00742 |
| ABHD6 | abhydrolase domain containing 6 | 2.00676 |
| CORO7-PAM16 | CORO7-PAM16 readthrough | 2.00532 |
| KCNAB3 | potassium channel, voltage gated subfamily A regulatory beta subunit 3 | 2.00504 |
| PAX2 | paired box 2 | 2.00255 |
| LSR | lipolysis stimulated lipoprotein receptor | 2.00069 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADI1 | acireductone dioxygenase 1 | -8.12005 |
| CCNB2 | cyclin B2 | -6.29578 |
| CD320 | CD320 molecule | -6.29243 |
| DERA | deoxyribose-phosphate aldolase (putative) | -6.18528 |
| TCERG1 | transcription elongation regulator 1 | -5.83736 |
| ICAM3 | intercellular adhesion molecule 3 | -5.59859 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -5.32352 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -5.14657 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -4.92061 |
| PGM1 | phosphoglucomutase 1 | -4.78286 |
| CCNA2 | cyclin A2 | -4.77736 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -4.72103 |
| DCK | deoxycytidine kinase | -4.67194 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -4.66405 |
| ATF5 | activating transcription factor 5 | -4.64196 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -4.52996 |
| TCTN1 | tectonic family member 1 | -4.48121 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -4.37327 |
| CDC20 | cell division cycle 20 | -4.30816 |
| KEAP1 | kelch-like ECH-associated protein 1 | -4.25267 |
| STAP2 | signal transducing adaptor family member 2 | -4.19328 |
| CHEK1 | checkpoint kinase 1 | -4.12018 |
| TATDN2 | TatD DNase domain containing 2 | -4.11397 |
| BCL7B | B-cell CLL/lymphoma 7B | -4.08903 |
| GLOD4 | glyoxalase domain containing 4 | -3.92417 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.86287 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -3.80901 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -3.66474 |
| NUP85 | nucleoporin 85kDa | -3.55818 |
| USP1 | ubiquitin specific peptidase 1 | -3.47812 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -3.39365 |
| PLK1 | polo-like kinase 1 | -3.37504 |
| ISOC1 | isochorismatase domain containing 1 | -3.32377 |
| CDK1 | cyclin-dependent kinase 1 | -3.30485 |
| TMEM109 | transmembrane protein 109 | -3.25792 |
| CDCA8 | cell division cycle associated 8 | -3.20724 |
| PCNA | proliferating cell nuclear antigen | -3.16197 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.12874 |
| MELK | maternal embryonic leucine zipper kinase | -3.10921 |
| ATMIN | ATM interactor | -3.09702 |
| RPIA | ribose 5-phosphate isomerase A | -3.07689 |
| LDHD | lactate dehydrogenase D | -3.06598 |
| GTPBP8 | GTP-binding protein 8 (putative) | -2.957 |
| SPAG7 | sperm associated antigen 7 | -2.95387 |
| ACOT2 | acyl-CoA thioesterase 2 | -2.87844 |
| TTK | TTK protein kinase | -2.82792 |
| PROS1 | protein S (alpha) | -2.76844 |
| NUDT15 | nudix (nucleoside diphosphate linked moiety X)-type motif 15 | -2.76359 |
| MTA1 | metastasis associated 1 | -2.7328 |
| NNT | nicotinamide nucleotide transhydrogenase | -2.73244 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -2.72725 |
| ZNF586 | zinc finger protein 586 | -2.70865 |
| SCCPDH | saccharopine dehydrogenase (putative) | -2.70269 |
| LRRC41 | leucine rich repeat containing 41 | -2.6802 |
| CENPN | centromere protein N | -2.67625 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -2.65824 |
| ECH1 | enoyl CoA hydratase 1, peroxisomal | -2.65738 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | -2.62146 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.61357 |
| SOAT2 | sterol O-acyltransferase 2 | -2.61215 |
| SAC3D1 | SAC3 domain containing 1 | -2.61143 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.60312 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.58883 |
| PHF2 | PHD finger protein 2 | -2.58592 |
| CDK4 | cyclin-dependent kinase 4 | -2.58505 |
| PPARG | peroxisome proliferator-activated receptor gamma | -2.57273 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -2.57226 |
| SQOR | sulfide quinone oxidoreductase | -2.57173 |
| POLE | polymerase (DNA directed), epsilon, catalytic subunit | -2.55083 |
| DSG2 | desmoglein 2 | -2.53891 |
| NCAPH | non-SMC condensin I complex, subunit H | -2.53575 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.4988 |
| LAGE3 | L antigen family, member 3 | -2.48257 |
| STAMBP | STAM binding protein | -2.4811 |
| IFRD2 | interferon-related developmental regulator 2 | -2.47351 |
| TXNDC9 | thioredoxin domain containing 9 | -2.46874 |
| SPAG4 | sperm associated antigen 4 | -2.45253 |
| GNAS | GNAS complex locus | -2.44835 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | -2.42476 |
| SLC25A38 | solute carrier family 25, member 38 | -2.39527 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -2.39149 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -2.3841 |
| MYLK | myosin light chain kinase | -2.38215 |
| CENPS-CORT | CENPS-CORT readthrough | -2.381 |
| FOXM1 | forkhead box M1 | -2.37247 |
| NLRP2B | NLR family pyrin domain containing 2B | -2.36743 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.35839 |
| LYRM1 | LYR motif containing 1 | -2.35778 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -2.34576 |
| TRIP13 | thyroid hormone receptor interactor 13 | -2.32649 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | -2.31809 |
| HJURP | Holliday junction recognition protein | -2.30629 |
| RBM14-RBM4 | RBM14-RBM4 readthrough | -2.29463 |
| PARP1 | poly (ADP-ribose) polymerase 1 | -2.2926 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.28437 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -2.28162 |
| SLC35B1 | solute carrier family 35, member B1 | -2.27438 |
| AURKA | aurora kinase A | -2.2661 |
| CASC3 | cancer susceptibility candidate 3 | -2.23883 |
| BPIFA1 | BPI fold containing family A, member 1 | -2.23757 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -2.22817 |
| DBF4 | DBF4 zinc finger | -2.22326 |
| KLHL21 | kelch-like family member 21 | -2.21804 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | -2.21673 |
| FBXO7 | F-box protein 7 | -2.20837 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -2.19152 |
| CDC25A | cell division cycle 25A | -2.18739 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.18332 |
| AUNIP | aurora kinase A and ninein interacting protein | -2.18028 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.17823 |
| NGRN | neugrin, neurite outgrowth associated | -2.17401 |
| CYP20A1 | cytochrome P450, family 20, subfamily A, polypeptide 1 | -2.1652 |
| HADH | hydroxyacyl-CoA dehydrogenase | -2.16345 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.15755 |
| THOC1 | THO complex 1 | -2.15611 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | -2.15575 |
| NCK2 | NCK adaptor protein 2 | -2.1536 |
| PNKP | polynucleotide kinase 3'-phosphatase | -2.14873 |
| CHAF1A | chromatin assembly factor 1, subunit A (p150) | -2.13117 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | -2.13037 |
| DEPDC1 | DEP domain containing 1 | -2.12951 |
| MRPS16 | mitochondrial ribosomal protein S16 | -2.11832 |
| PEG10 | paternally expressed 10 | -2.11023 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -2.10891 |
| MRPS15 | mitochondrial ribosomal protein S15 | -2.10312 |
| DNM1L | dynamin 1-like | -2.10043 |
| DCXR | dicarbonyl/L-xylulose reductase | -2.09618 |
| SMNDC1 | survival motor neuron domain containing 1 | -2.08956 |
| EAPP | E2F-associated phosphoprotein | -2.08929 |
| DPP8 | dipeptidyl-peptidase 8 | -2.08313 |
| CPSF7 | cleavage and polyadenylation specific factor 7, 59kDa | -2.07931 |
| TPM1 | tropomyosin 1 (alpha) | -2.07889 |
| CDT1 | chromatin licensing and DNA replication factor 1 | -2.07263 |
| POLD1 | polymerase (DNA directed), delta 1, catalytic subunit | -2.05603 |
| TTLL7 | tubulin tyrosine ligase-like family member 7 | -2.0407 |
| POLA2 | polymerase (DNA directed), alpha 2, accessory subunit | -2.03798 |
| YTHDF3 | YTH N(6)-methyladenosine RNA binding protein 3 | -2.03398 |
| ZNHIT3 | zinc finger, HIT-type containing 3 | -2.02812 |
| DPF2 | D4, zinc and double PHD fingers family 2 | -2.02471 |
| ACYP2 | acylphosphatase 2, muscle type | -2.02408 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -2.02198 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -2.01606 |
| GPN1 | GPN-loop GTPase 1 | -2.01386 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -2.00746 |
| TIMELESS | timeless circadian clock | -2.00459 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | -2.00092 |
