CRCGN013_HEPG2_24H:N21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetonitrile 10.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN013_HEPG2_24H:N21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOSIP nitric oxide synthase interacting protein 4.56956
CIAO3 cytosolic iron-sulfur assembly component 3 4.1007
STK10 serine/threonine kinase 10 4.08417
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.08272
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.07009
GPER1 G protein-coupled estrogen receptor 1 3.65199
CXCR4 chemokine (C-X-C motif) receptor 4 3.59006
AMDHD2 amidohydrolase domain containing 2 3.54109
HLA-DMA major histocompatibility complex, class II, DM alpha 3.24724
MAP7 microtubule-associated protein 7 2.94598
MOK MOK protein kinase 2.92303
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.89743
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.78679
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.76734
C2CD2 C2 calcium-dependent domain containing 2 2.58806
GSTZ1 glutathione S-transferase zeta 1 2.4495
ABHD6 abhydrolase domain containing 6 2.41902
CCNA1 cyclin A1 2.40952
SKIC8 SKI8 subunit of superkiller complex 2.3217
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.22541
VGLL4 vestigial-like family member 4 2.14403
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 2.10239
SMIM40 small integral membrane protein 40 2.07726
HLA-DRA major histocompatibility complex, class II, DR alpha 2.06351
BAMBI BMP and activin membrane-bound inhibitor 2.01439
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.01165

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -7.40783
GDF15 growth differentiation factor 15 -7.33564
CCDC86 coiled-coil domain containing 86 -7.10366
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -6.4117
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.54547
KDM3A lysine (K)-specific demethylase 3A -4.32055
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.2743
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.49429
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.38429
ZMIZ1 zinc finger, MIZ-type containing 1 -2.91855
CAB39 calcium binding protein 39 -2.88569
CHMP4B charged multivesicular body protein 4B -2.63073
DUSP14 dual specificity phosphatase 14 -2.51833
TXNRD1 thioredoxin reductase 1 -2.4523
RNF167 ring finger protein 167 -2.41191
EGF epidermal growth factor -2.26847
OSMR oncostatin M receptor -2.10621
SOD3 superoxide dismutase 3, extracellular -2.0873
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.02904