CRCGN013_HEPG2_24H:O10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isobutyraldehyde 5.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN013_HEPG2_24H:O10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 4.6823
MINDY1 MINDY lysine 48 deubiquitinase 1 4.24987
LAGE3 L antigen family, member 3 4.00896
DENND2D DENN/MADD domain containing 2D 3.76997
UBQLN2 ubiquilin 2 3.62375
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.53184
GPATCH8 G patch domain containing 8 3.44597
ABHD6 abhydrolase domain containing 6 3.32918
CXCL2 chemokine (C-X-C motif) ligand 2 3.29454
H2BC12 H2B clustered histone 12 3.18419
ADAT1 adenosine deaminase, tRNA-specific 1 2.96237
SFTPB surfactant protein B 2.51608
LGALS8 lectin, galactoside-binding, soluble, 8 2.40651
CEP57 centrosomal protein 57kDa 2.38122
E2F2 E2F transcription factor 2 2.31656
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.30292
RPP38 ribonuclease P/MRP 38kDa subunit 2.26331
GADD45A growth arrest and DNA-damage-inducible, alpha 2.23636
GPER1 G protein-coupled estrogen receptor 1 2.21044
HLA-DRA major histocompatibility complex, class II, DR alpha 2.18411
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.15428
DEFA4 defensin, alpha 4, corticostatin 2.06199
ECD ecdysoneless homolog (Drosophila) 2.05704

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -6.27859
NT5DC2 5'-nucleotidase domain containing 2 -5.90935
GNAS GNAS complex locus -5.53032
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.30837
CD320 CD320 molecule -4.14334
GOLT1B golgi transport 1B -4.114
TRIB3 tribbles pseudokinase 3 -4.09043
INPP1 inositol polyphosphate-1-phosphatase -4.07195
SMNDC1 survival motor neuron domain containing 1 -3.92742
GDF15 growth differentiation factor 15 -3.77331
KDM3A lysine (K)-specific demethylase 3A -3.73417
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.67896
MRPS2 mitochondrial ribosomal protein S2 -3.62406
NUP85 nucleoporin 85kDa -3.56724
LDHD lactate dehydrogenase D -3.52196
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.39841
EIF5 eukaryotic translation initiation factor 5 -3.36214
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.96016
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.77406
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.71426
LAP3 leucine aminopeptidase 3 -2.68915
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.63282
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.52113
PCCB propionyl CoA carboxylase, beta polypeptide -2.48285
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.4759
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.35691
SLC35F2 solute carrier family 35, member F2 -2.33379
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.30791
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.2782
WASHC4 WASH complex subunit 4 -2.19119
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.09195