CRCGN013_HEPG2_24H:O12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isobutyraldehyde 1.28 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN013_HEPG2_24H:O12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 8.11524
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.32814
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.07999
CBR3 carbonyl reductase 3 4.80648
GPATCH8 G patch domain containing 8 4.41337
CXCL2 chemokine (C-X-C motif) ligand 2 4.07325
ATP11B ATPase, class VI, type 11B 4.04422
LCN2 lipocalin 2 3.59375
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.08917
DYNLT3 dynein, light chain, Tctex-type 3 3.03054
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.95802
GSTZ1 glutathione S-transferase zeta 1 2.95157
ADAT1 adenosine deaminase, tRNA-specific 1 2.83302
CCDC92 coiled-coil domain containing 92 2.77989
RSAD2 radical S-adenosyl methionine domain containing 2 2.56164
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.46905
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.42474
SCRN1 secernin 1 2.27645
LOC122526780 uncharacterized LOC122526780 2.23964
IFI44L interferon-induced protein 44-like 2.22195
ZFP36 ZFP36 ring finger protein 2.20176
MX1 MX dynamin-like GTPase 1 2.13141
UNC13D unc-13 homolog D (C. elegans) 2.07501
IPO13 importin 13 2.07061
MUC16 mucin 16, cell surface associated 2.06809
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.02373
ANO10 anoctamin 10 2.01821
ITM2A integral membrane protein 2A 2.00623
SPTBN2 spectrin, beta, non-erythrocytic 2 2.00508
FHL2 four and a half LIM domains 2 2.0029

decreased expression

Symbol Name Standardized Value
FASTKD5 FAST kinase domains 5 -5.51708
GOLT1B golgi transport 1B -5.42103
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.08487
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.92034
CHMP4B charged multivesicular body protein 4B -4.23125
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.65243
MAP7 microtubule-associated protein 7 -3.2942
RPS5 ribosomal protein S5 -3.14629
TLCD3A TLC domain containing 3A -2.96569
TMEM267 transmembrane protein 267 -2.79444
TEX10 testis expressed 10 -2.78655
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.5296
MAPK13 mitogen-activated protein kinase 13 -2.43305
TCTN1 tectonic family member 1 -2.30862
RNPS1 RNA binding protein S1, serine-rich domain -2.22708
PDS5A PDS5 cohesin associated factor A -2.22685
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -2.12381
PXDC1 PX domain containing 1 -2.11115
GUF1 GUF1 GTPase homolog (S. cerevisiae) -2.01615
WASHC4 WASH complex subunit 4 -2.00061