CRCGN013_HEPG2_24H:O14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dieldrin 20.3 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN013_HEPG2_24H:O14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 4.72856
CHN1 chimerin 1 4.64487
TIAM1 T-cell lymphoma invasion and metastasis 1 4.40585
HOXA10 homeobox A10 3.91064
AMDHD2 amidohydrolase domain containing 2 3.82678
CIAO3 cytosolic iron-sulfur assembly component 3 3.25778
HDGFL3 HDGF like 3 3.07726
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 3.04799
GPATCH8 G patch domain containing 8 2.743
STK10 serine/threonine kinase 10 2.70097
KIFBP kinesin family binding protein 2.63878
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.45709
TLR4 toll-like receptor 4 2.3538
EPN2 epsin 2 2.23909
TBP TATA box binding protein 2.22454
DYNLT3 dynein, light chain, Tctex-type 3 2.21745
MCUR1 mitochondrial calcium uniporter regulator 1 2.19505
PRAF2 PRA1 domain family, member 2 2.19015
PLS1 plastin 1 2.10115

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -4.44314
CCDC86 coiled-coil domain containing 86 -3.60727
LDHD lactate dehydrogenase D -3.543
PCNA proliferating cell nuclear antigen -3.48526
GDF15 growth differentiation factor 15 -3.13455
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.08122
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.88763
TNIP1 TNFAIP3 interacting protein 1 -2.8796
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.67386
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.63858
COG2 component of oligomeric golgi complex 2 -2.52613
EGF epidermal growth factor -2.45831
MAPK13 mitogen-activated protein kinase 13 -2.44493
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.07138
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.00925