CRCGN013_HEPG2_24H:O17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dieldrin 2.54 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

163 genes differentially expressed following the CRCGN013_HEPG2_24H:O17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.94793
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.59866
PPARG peroxisome proliferator-activated receptor gamma 4.54032
ABHD6 abhydrolase domain containing 6 4.15877
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.59771
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.47473
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.37731
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.28568
BACE2 beta-site APP-cleaving enzyme 2 3.19103
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.10048
SSBP2 single-stranded DNA binding protein 2 3.02899
E2F2 E2F transcription factor 2 3.02292
NANOS3 nanos homolog 3 (Drosophila) 2.97394
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.9426
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.9046
MAMLD1 mastermind-like domain containing 1 2.88771
COL4A1 collagen, type IV, alpha 1 2.83221
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.81667
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.79382
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.76817
CBLN1 cerebellin 1 precursor 2.75286
ZNF318 zinc finger protein 318 2.749
BBS7 Bardet-Biedl syndrome 7 2.72392
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.69877
EPHB2 EPH receptor B2 2.65191
ETV1 ets variant 1 2.6202
NOSIP nitric oxide synthase interacting protein 2.60191
GARRE1 granule associated Rac and RHOG effector 1 2.59263
LAGE3 L antigen family, member 3 2.59102
EGF epidermal growth factor 2.56073
LCN2 lipocalin 2 2.55932
GRWD1 glutamate-rich WD repeat containing 1 2.55307
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.54419
CARMIL1 capping protein regulator and myosin 1 linker 1 2.52386
CCL1 chemokine (C-C motif) ligand 1 2.51656
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 2.50252
DENND4A DENN/MADD domain containing 4A 2.49717
CAPN1 calpain 1, (mu/I) large subunit 2.49074
SNAP25 synaptosomal-associated protein, 25kDa 2.47904
NEO1 neogenin 1 2.45658
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 2.43785
LIFR leukemia inhibitory factor receptor alpha 2.41325
ERBB4 erb-b2 receptor tyrosine kinase 4 2.41269
ARHGAP24 Rho GTPase activating protein 24 2.40988
FST follistatin 2.39774
TAC4 tachykinin 4 (hemokinin) 2.39469
RLN2 relaxin 2 2.38325
RORB RAR-related orphan receptor B 2.35139
SGMS1 sphingomyelin synthase 1 2.34862
ADAT1 adenosine deaminase, tRNA-specific 1 2.34157
SALL1 spalt-like transcription factor 1 2.31129
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.30132
MMP27 matrix metallopeptidase 27 2.2805
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.27919
CD207 CD207 molecule, langerin 2.26686
PELI1 pellino E3 ubiquitin protein ligase 1 2.26046
SCYL3 SCY1-like 3 (S. cerevisiae) 2.22987
NEURL1 neuralized E3 ubiquitin protein ligase 1 2.22957
CXCR1 chemokine (C-X-C motif) receptor 1 2.2277
FAM204A family with sequence similarity 204, member A 2.19859
TSC22D3 TSC22 domain family, member 3 2.19408
ZNF154 zinc finger protein 154 2.19304
KLHL21 kelch-like family member 21 2.18624
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.18223
NAIP NLR family, apoptosis inhibitory protein 2.18035
BPHL biphenyl hydrolase-like (serine hydrolase) 2.17874
PRKCE protein kinase C, epsilon 2.17712
ADRB2 adrenoceptor beta 2, surface 2.17097
TIAM1 T-cell lymphoma invasion and metastasis 1 2.1698
CALB1 calbindin 1, 28kDa 2.16954
ZFP37 ZFP37 zinc finger protein 2.1659
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 2.16227
IL9 interleukin 9 2.16146
RPA4 replication protein A4, 30kDa 2.15075
GPR63 G protein-coupled receptor 63 2.14657
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 2.1465
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.14194
DNM1 dynamin 1 2.13727
FXYD2 FXYD domain containing ion transport regulator 2 2.13675
MARCHF1 membrane associated ring-CH-type finger 1 2.13087
PFKL phosphofructokinase, liver 2.12892
MAP3K8 mitogen-activated protein kinase kinase kinase 8 2.1263
SLCO4C1 solute carrier organic anion transporter family, member 4C1 2.11813
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.1113
TOP2A topoisomerase (DNA) II alpha 170kDa 2.11087
CA10 carbonic anhydrase X 2.10891
TRPC3 transient receptor potential cation channel, subfamily C, member 3 2.10015
NPDC1 neural proliferation, differentiation and control, 1 2.09985
GTF2IRD2B GTF2I repeat domain containing 2B 2.08654
ZMYM1 zinc finger, MYM-type 1 2.08129
NABP1 nucleic acid binding protein 1 2.07435
SCN1B sodium channel, voltage gated, type I beta subunit 2.07334
PRR15L proline rich 15-like 2.06551
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 2.06057
TBC1D10C TBC1 domain family, member 10C 2.0595
TLR7 toll-like receptor 7 2.05674
PGPEP1 pyroglutamyl-peptidase I 2.05313
ENPEP glutamyl aminopeptidase (aminopeptidase A) 2.04799
PLA2R1 phospholipase A2 receptor 1, 180kDa 2.0449
SSTR1 somatostatin receptor 1 2.03891
PDLIM1 PDZ and LIM domain 1 2.03475
HIP1 huntingtin interacting protein 1 2.03445
GRM6 glutamate receptor, metabotropic 6 2.02468
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.01309
SYTL3 synaptotagmin-like 3 2.01143
LGI2 leucine-rich repeat LGI family, member 2 2.00988
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.00242

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.35098
LDHD lactate dehydrogenase D -7.23891
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.54539
ADI1 acireductone dioxygenase 1 -4.6935
CAB39 calcium binding protein 39 -4.43484
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.11387
FGFR4 fibroblast growth factor receptor 4 -3.93674
MRPS16 mitochondrial ribosomal protein S16 -2.9357
NRIP1 nuclear receptor interacting protein 1 -2.83192
DUSP6 dual specificity phosphatase 6 -2.73809
TXNDC9 thioredoxin domain containing 9 -2.71359
KDM3A lysine (K)-specific demethylase 3A -2.70957
HAT1 histone acetyltransferase 1 -2.66913
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.66902
LAP3 leucine aminopeptidase 3 -2.64465
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.60483
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.55932
NCK1 NCK adaptor protein 1 -2.54745
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.54245
GFUS GDP-L-fucose synthase -2.53685
ACOT9 acyl-CoA thioesterase 9 -2.52164
ITGB1BP1 integrin beta 1 binding protein 1 -2.47645
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.46747
LYPLA1 lysophospholipase I -2.46341
GET1 guided entry of tail-anchored proteins factor 1 -2.46192
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.45038
TM9SF2 transmembrane 9 superfamily member 2 -2.42159
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.41713
PTDSS2 phosphatidylserine synthase 2 -2.38523
MRPL15 mitochondrial ribosomal protein L15 -2.37319
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.36414
MXRA7 matrix-remodelling associated 7 -2.32836
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.29909
ECM1 extracellular matrix protein 1 -2.28375
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.27788
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.25487
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.24347
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.21768
POMP proteasome maturation protein -2.20693
WASHC4 WASH complex subunit 4 -2.17263
EAPP E2F-associated phosphoprotein -2.17235
CD320 CD320 molecule -2.13259
PDIA5 protein disulfide isomerase family A, member 5 -2.11759
TBCB tubulin folding cofactor B -2.10497
ZW10 zw10 kinetochore protein -2.10026
IFT52 intraflagellar transport 52 -2.09254
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.05171
CD58 CD58 molecule -2.05044
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -2.04787
TIMP3 TIMP metallopeptidase inhibitor 3 -2.04557
TMEM59 transmembrane protein 59 -2.03582
ICAM3 intercellular adhesion molecule 3 -2.02955
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.01622
COX7B cytochrome c oxidase subunit VIIb -2.00666
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.00124
CRYZ crystallin, zeta (quinone reductase) -2.00011