CRCGN013_HEPG2_24H:O19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (e)-3h-indol-3-ylidenemethanol 21.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN013_HEPG2_24H:O19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 4.24883
MEF2C myocyte enhancer factor 2C 3.38716
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.37931
BZW2 basic leucine zipper and W2 domains 2 3.16374
TREM1 triggering receptor expressed on myeloid cells 1 3.12283
RPP38 ribonuclease P/MRP 38kDa subunit 2.61052
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.52361
LRP10 low density lipoprotein receptor-related protein 10 2.46608
PPARG peroxisome proliferator-activated receptor gamma 2.41504
SFTPB surfactant protein B 2.30438
CHN1 chimerin 1 2.30235
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.23288
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.1742
SLC35E2B solute carrier family 35, member E2B 2.09965
PEX11A peroxisomal biogenesis factor 11 alpha 2.08678
ADRB2 adrenoceptor beta 2, surface 2.03989

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.56
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.46052
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.31462
CCDC86 coiled-coil domain containing 86 -4.29593
CD320 CD320 molecule -4.06582
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -3.66995
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.61784
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.45313
CCP110 centriolar coiled coil protein 110kDa -3.35021
TM9SF3 transmembrane 9 superfamily member 3 -3.20441
CAB39 calcium binding protein 39 -3.07994
KDM3A lysine (K)-specific demethylase 3A -3.05037
RPS5 ribosomal protein S5 -2.96608
PEG10 paternally expressed 10 -2.80033
TLCD3A TLC domain containing 3A -2.44298
ZW10 zw10 kinetochore protein -2.42885
GNAS GNAS complex locus -2.21653
TCTN1 tectonic family member 1 -2.19401
NGRN neugrin, neurite outgrowth associated -2.17557
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.17439
LOC124907782 dual specificity protein phosphatase 22 -2.15848
TEX10 testis expressed 10 -2.14661