CRCGN013_HEPG2_24H:O22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (e)-3h-indol-3-ylidenemethanol 2.65 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN013_HEPG2_24H:O22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIAM1 T-cell lymphoma invasion and metastasis 1 5.19035
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.70235
CCNF cyclin F 4.31409
UBQLN2 ubiquilin 2 4.29656
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.22436
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.04248
CYCS cytochrome c, somatic 3.94613
GPER1 G protein-coupled estrogen receptor 1 3.42885
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.40297
CBR3 carbonyl reductase 3 3.39927
LOC122526780 uncharacterized LOC122526780 3.11847
GATA3 GATA binding protein 3 2.8446
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.74195
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.61978
KLHL9 kelch-like family member 9 2.47749
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.37858
DYNLT3 dynein, light chain, Tctex-type 3 2.34021
PRR15L proline rich 15-like 2.05072

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -4.58664
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.20298
CCDC86 coiled-coil domain containing 86 -3.77754
MAP7 microtubule-associated protein 7 -3.75895
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.59034
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.54805
VAT1 vesicle amine transport 1 -3.45631
MRPS2 mitochondrial ribosomal protein S2 -3.38085
DERA deoxyribose-phosphate aldolase (putative) -3.09651
TLCD3A TLC domain containing 3A -2.88514
FBXL12 F-box and leucine-rich repeat protein 12 -2.81686
SNX11 sorting nexin 11 -2.41688
PAEP progestagen-associated endometrial protein -2.23267
EXT1 exostosin glycosyltransferase 1 -2.04972
TXLNG taxilin gamma -2.02466
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.00795