CRCGN013_HEPG2_24H:P02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disulfiram 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

302 genes differentially expressed following the CRCGN013_HEPG2_24H:P02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 9.6537
CDPF1 cysteine-rich, DPF motif domain containing 1 8.72518
TIMP2 TIMP metallopeptidase inhibitor 2 7.55332
ASCC3 activating signal cointegrator 1 complex subunit 3 7.1425
MVP major vault protein 5.96222
BAD BCL2-associated agonist of cell death 5.68344
BZW2 basic leucine zipper and W2 domains 2 5.54727
CTSL cathepsin L 5.51319
EGF epidermal growth factor 5.44218
AMDHD2 amidohydrolase domain containing 2 5.21177
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 5.1688
INPP1 inositol polyphosphate-1-phosphatase 5.08071
LRP10 low density lipoprotein receptor-related protein 10 4.6861
MINDY1 MINDY lysine 48 deubiquitinase 1 4.64678
STX1A syntaxin 1A (brain) 4.5498
RRAGA Ras-related GTP binding A 4.34998
CCL2 chemokine (C-C motif) ligand 2 4.17415
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.14139
CHN1 chimerin 1 4.10535
NOSIP nitric oxide synthase interacting protein 4.04267
SFTPB surfactant protein B 3.84443
TUBB6 tubulin, beta 6 class V 3.83468
CBR3 carbonyl reductase 3 3.77442
CXCL2 chemokine (C-X-C motif) ligand 2 3.74268
SQOR sulfide quinone oxidoreductase 3.65811
PARP2 poly (ADP-ribose) polymerase 2 3.60487
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.58008
HLA-DRA major histocompatibility complex, class II, DR alpha 3.50185
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.44605
FOSL1 FOS-like antigen 1 3.44503
ACOT9 acyl-CoA thioesterase 9 3.39115
TMEM109 transmembrane protein 109 3.39082
BLCAP bladder cancer associated protein 3.25296
DHRS7 dehydrogenase/reductase (SDR family) member 7 3.22883
BPHL biphenyl hydrolase-like (serine hydrolase) 3.1752
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.16556
ANKRD36C ankyrin repeat domain 36C 3.14011
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 3.10426
CASC3 cancer susceptibility candidate 3 3.06178
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 3.04184
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.03619
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 3.01557
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.99651
EGR1 early growth response 1 2.95024
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.8782
GRB10 growth factor receptor-bound protein 10 2.87721
BATF basic leucine zipper transcription factor, ATF-like 2.87111
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.86271
MACF1 microtubule-actin crosslinking factor 1 2.85185
KDM5A lysine (K)-specific demethylase 5A 2.83261
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.83034
STK10 serine/threonine kinase 10 2.82937
PRKCD protein kinase C, delta 2.81766
MICALL1 MICAL-like 1 2.79492
THTPA thiamine triphosphatase 2.78196
RALB v-ral simian leukemia viral oncogene homolog B 2.75168
CFLAR CASP8 and FADD-like apoptosis regulator 2.70414
ALAS1 5'-aminolevulinate synthase 1 2.70264
MED15 mediator complex subunit 15 2.697
S100A4 S100 calcium binding protein A4 2.68609
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.67306
RTF2 replication termination factor 2 2.65233
LOC124907782 dual specificity protein phosphatase 22 2.61793
E2F2 E2F transcription factor 2 2.61459
PLS1 plastin 1 2.60797
RANBP2 RAN binding protein 2 2.59591
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 2.59282
MECR mitochondrial trans-2-enoyl-CoA reductase 2.50862
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.49022
SLC12A9 solute carrier family 12, member 9 2.48276
LIF leukemia inhibitory factor 2.48075
DPF2 D4, zinc and double PHD fingers family 2 2.43552
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 2.43202
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.42963
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.42451
BLVRA biliverdin reductase A 2.40794
USP19 ubiquitin specific peptidase 19 2.40784
CHMP6 charged multivesicular body protein 6 2.40343
ECI2 enoyl-CoA delta isomerase 2 2.39938
DUX4 double homeobox 4 2.37889
GLRX glutaredoxin (thioltransferase) 2.37546
MAP7D1 MAP7 domain containing 1 2.36758
GPATCH3 G patch domain containing 3 2.36088
ARHGAP12 Rho GTPase activating protein 12 2.35082
STX4 syntaxin 4 2.35003
EVA1B eva-1 homolog B (C. elegans) 2.34592
COG4 component of oligomeric golgi complex 4 2.34549
SF3B2 splicing factor 3b, subunit 2, 145kDa 2.3372
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 2.33461
CDC25B cell division cycle 25B 2.33447
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.32742
MRPS2 mitochondrial ribosomal protein S2 2.3194
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.31752
TRAPPC8 trafficking protein particle complex 8 2.31645
WDR37 WD repeat domain 37 2.31027
CHERP calcium homeostasis endoplasmic reticulum protein 2.30957
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2.29332
VGLL4 vestigial-like family member 4 2.28919
TWF2 twinfilin actin binding protein 2 2.28206
DCTN1 dynactin 1 2.28139
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.27587
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.26946
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.26316
GIPC1 GIPC PDZ domain containing family, member 1 2.26204
UBR2 ubiquitin protein ligase E3 component n-recognin 2 2.25604
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.23972
STAMBP STAM binding protein 2.23714
PANX1 pannexin 1 2.23244
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.22693
NLRP2B NLR family pyrin domain containing 2B 2.22419
BICD2 bicaudal D homolog 2 (Drosophila) 2.21871
GAK cyclin G associated kinase 2.21552
ZDHHC24 zinc finger, DHHC-type containing 24 2.21462
CLDN8 claudin 8 2.20177
DUSP14 dual specificity phosphatase 14 2.19928
SLC35F6 solute carrier family 35, member F6 2.19645
SRP54 signal recognition particle 54kDa 2.19066
SETBP1 SET binding protein 1 2.18996
PRMT5 protein arginine methyltransferase 5 2.18859
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 2.18363
MAPK13 mitogen-activated protein kinase 13 2.18076
SACS sacsin molecular chaperone 2.17166
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 2.17006
BAZ1A bromodomain adjacent to zinc finger domain, 1A 2.16812
TOP6BL TOP6B like initiator of meiotic double strand breaks 2.16469
UBE2A ubiquitin-conjugating enzyme E2A 2.15842
RPL39L ribosomal protein L39-like 2.14825
CDC45 cell division cycle 45 2.14786
CSAG2 CSAG family, member 2 2.14739
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.138
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.13059
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 2.12675
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.12607
CUL7 cullin 7 2.12523
PCDHB11 protocadherin beta 11 2.12396
RBFA ribosome binding factor A (putative) 2.11941
GET3 guided entry of tail-anchored proteins factor 3, ATPase 2.11762
HAND2 heart and neural crest derivatives expressed 2 2.10976
CILK1 ciliogenesis associated kinase 1 2.10614
BTBD2 BTB (POZ) domain containing 2 2.10576
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.1048
PDE1A phosphodiesterase 1A, calmodulin-dependent 2.10447
DNM2 dynamin 2 2.10282
E4F1 E4F transcription factor 1 2.10268
STAP2 signal transducing adaptor family member 2 2.09609
DGKG diacylglycerol kinase, gamma 90kDa 2.09406
CYCS cytochrome c, somatic 2.09094
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.09055
APH1B APH1B gamma secretase subunit 2.08683
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.08678
ATG7 autophagy related 7 2.08457
WDR44 WD repeat domain 44 2.08378
FAT1 FAT atypical cadherin 1 2.0835
TOMM34 translocase of outer mitochondrial membrane 34 2.08154
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.07899
IGF2R insulin-like growth factor 2 receptor 2.07898
TRIB1 tribbles pseudokinase 1 2.07597
ERCC1 excision repair cross-complementation group 1 2.06897
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.06848
PTGES2 prostaglandin E synthase 2 2.06837
TBX19 T-box 19 2.06831
DUSP6 dual specificity phosphatase 6 2.06673
RGPD2 RANBP2-like and GRIP domain containing 2 2.06558
ILF2 interleukin enhancer binding factor 2 2.06366
GSTA4 glutathione S-transferase alpha 4 2.06338
SMAD3 SMAD family member 3 2.05235
IL6R interleukin 6 receptor 2.05201
KLF13 Kruppel-like factor 13 2.04834
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.04711
TBL3 transducin (beta)-like 3 2.04613
TBXT T-box transcription factor T 2.04124
PNMA3 paraneoplastic Ma antigen 3 2.03644
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 2.03474
CAVIN2 caveolae associated protein 2 2.03172
ANGPTL4 angiopoietin-like 4 2.02732
LOC124908558 X antigen family member 1-like 2.02415
DVL1 dishevelled segment polarity protein 1 2.02292
TGM5 transglutaminase 5 2.02135
HOMER2 homer scaffolding protein 2 2.02031
TRIM27 tripartite motif containing 27 2.0162
PCBP4 poly(rC) binding protein 4 2.01559
TMEM50A transmembrane protein 50A 2.01493
MZT2B mitotic spindle organizing protein 2B 2.01044
ZBTB38 zinc finger and BTB domain containing 38 2.00791
PUM1 pumilio RNA-binding family member 1 2.00618
UBXN4 UBX domain protein 4 2.00237
EIF6 eukaryotic translation initiation factor 6 2.00144

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
ISOC1 isochorismatase domain containing 1 -9.44148
C5 complement component 5 -8.66313
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -7.64954
FGFR4 fibroblast growth factor receptor 4 -7.45785
PECR peroxisomal trans-2-enoyl-CoA reductase -6.7574
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.39171
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -5.54099
ZW10 zw10 kinetochore protein -5.00085
PTPRK protein tyrosine phosphatase, receptor type, K -4.97026
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.69955
SOAT2 sterol O-acyltransferase 2 -4.67768
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.613
NGRN neugrin, neurite outgrowth associated -4.58133
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.53115
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.4833
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.92252
CRELD2 cysteine-rich with EGF-like domains 2 -3.90197
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.66963
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -3.62799
AURKB aurora kinase B -3.54074
TCTN1 tectonic family member 1 -3.53621
PGM1 phosphoglucomutase 1 -3.48141
ITGB1BP1 integrin beta 1 binding protein 1 -3.40461
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -3.2488
KIF14 kinesin family member 14 -3.18534
EXT1 exostosin glycosyltransferase 1 -3.15225
GOLT1B golgi transport 1B -3.12917
ZDHHC6 zinc finger, DHHC-type containing 6 -3.11486
MSMO1 methylsterol monooxygenase 1 -3.03721
DENND2D DENN/MADD domain containing 2D -3.01088
FAIM Fas apoptotic inhibitory molecule -3.00488
ALDOC aldolase C, fructose-bisphosphate -2.97724
CLIC4 chloride intracellular channel 4 -2.97355
DSCC1 DNA replication and sister chromatid cohesion 1 -2.9698
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.91341
CHEK1 checkpoint kinase 1 -2.90674
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.87647
SCD stearoyl-CoA desaturase (delta-9-desaturase) -2.86719
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -2.8279
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.8262
TNIP1 TNFAIP3 interacting protein 1 -2.81742
PSRC1 proline/serine-rich coiled-coil 1 -2.79983
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.79054
CCDC51 coiled-coil domain containing 51 -2.71127
HSPA1A heat shock 70kDa protein 1A -2.70797
UROS uroporphyrinogen III synthase -2.64397
TRIB3 tribbles pseudokinase 3 -2.63277
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.61507
TRAF5 TNF receptor-associated factor 5 -2.60783
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.59349
CCNB2 cyclin B2 -2.58329
TMEM97 transmembrane protein 97 -2.57741
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.57496
PHGDH phosphoglycerate dehydrogenase -2.57373
MSH2 mutS homolog 2 -2.54046
RHOBTB1 Rho-related BTB domain containing 1 -2.53046
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.52669
ECH1 enoyl CoA hydratase 1, peroxisomal -2.4493
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.43002
DDIT4 DNA-damage-inducible transcript 4 -2.42965
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.41689
C2CD5 C2 calcium-dependent domain containing 5 -2.39317
ZNF586 zinc finger protein 586 -2.37391
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.36577
UGDH UDP-glucose 6-dehydrogenase -2.36126
RIDA reactive intermediate imine deaminase A homolog -2.35098
WDR76 WD repeat domain 76 -2.34755
ARID5B AT rich interactive domain 5B (MRF1-like) -2.34728
EAPP E2F-associated phosphoprotein -2.34604
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.34235
INHBE inhibin, beta E -2.33727
GMCL1 germ cell-less, spermatogenesis associated 1 -2.32089
RUVBL1 RuvB-like AAA ATPase 1 -2.31732
HTRA1 HtrA serine peptidase 1 -2.31262
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine -2.30961
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.30611
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.28428
PEX11A peroxisomal biogenesis factor 11 alpha -2.28368
ZDHHC4 zinc finger, DHHC-type containing 4 -2.27773
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.2722
CTSD cathepsin D -2.2697
AGMAT agmatine ureohydrolase (agmatinase) -2.26018
SQLE squalene epoxidase -2.25507
PRCP prolylcarboxypeptidase (angiotensinase C) -2.24517
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.23529
RAI14 retinoic acid induced 14 -2.2324
LOC102724560 cystathionine beta-synthase -2.22923
GNAS GNAS complex locus -2.20695
MRPL44 mitochondrial ribosomal protein L44 -2.18278
MORF4L1 mortality factor 4 like 1 -2.17751
NR1H4 nuclear receptor subfamily 1, group H, member 4 -2.16026
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.16015
PTEN phosphatase and tensin homolog -2.15925
DGKH diacylglycerol kinase, eta -2.15003
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.14857
ITPKB inositol-trisphosphate 3-kinase B -2.14295
ATRNL1 attractin-like 1 -2.14197
OAT ornithine aminotransferase -2.1375
R3HCC1L R3H domain and coiled-coil containing 1-like -2.13336
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.11771
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.10486
DENND10 DENN domain containing 10 -2.10105
PDF peptide deformylase (mitochondrial) -2.09991
TCERG1 transcription elongation regulator 1 -2.0762
AVPI1 arginine vasopressin-induced 1 -2.07411
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -2.05535
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.04803
HIKESHI heat shock protein nuclear import factor hikeshi -2.04475
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.04398
OPRK1 opioid receptor, kappa 1 -2.04009
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -2.03809
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.0198
AIRIM AFG2 interacting ribosome maturation factor -2.00422
EXO1 exonuclease 1 -2.00255