CRCGN013_HEPG2_24H:P05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disulfiram 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

51 genes differentially expressed following the CRCGN013_HEPG2_24H:P05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.458
LCN2 lipocalin 2 6.83813
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.06156
TIAM1 T-cell lymphoma invasion and metastasis 1 5.2008
STK10 serine/threonine kinase 10 4.2982
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 4.13091
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.85115
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.73302
LYN LYN proto-oncogene, Src family tyrosine kinase 3.5618
MOK MOK protein kinase 3.3656
TERT telomerase reverse transcriptase 3.1392
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.90407
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.85678
AMDHD2 amidohydrolase domain containing 2 2.84348
CHMP6 charged multivesicular body protein 6 2.81398
BAX BCL2-associated X protein 2.80581
CBR3 carbonyl reductase 3 2.57286
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.48293
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.42552
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.25347
MSRA methionine sulfoxide reductase A 2.23373
E2F2 E2F transcription factor 2 2.23015
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.22119
SSBP2 single-stranded DNA binding protein 2 2.19638
CIAO3 cytosolic iron-sulfur assembly component 3 2.19144
CREG1 cellular repressor of E1A-stimulated genes 1 2.16997
NOSIP nitric oxide synthase interacting protein 2.14458
ANKRD36C ankyrin repeat domain 36C 2.12741
ZNF787 zinc finger protein 787 2.10975
PRPF39 pre-mRNA processing factor 39 2.09393
CCDC86 coiled-coil domain containing 86 2.07551
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.01501

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.99882
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.9146
ZMIZ1 zinc finger, MIZ-type containing 1 -4.47124
SLC35F2 solute carrier family 35, member F2 -4.39445
HAT1 histone acetyltransferase 1 -4.1068
PRCP prolylcarboxypeptidase (angiotensinase C) -3.73344
LDHD lactate dehydrogenase D -3.28609
SNX11 sorting nexin 11 -2.96805
OXA1L oxidase (cytochrome c) assembly 1-like -2.89242
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.86781
EBNA1BP2 EBNA1 binding protein 2 -2.63678
NRIP1 nuclear receptor interacting protein 1 -2.58833
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.46597
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.45242
CRELD2 cysteine-rich with EGF-like domains 2 -2.3437
AK5 adenylate kinase 5 -2.15891
TLR4 toll-like receptor 4 -2.07686
LMBRD1 LMBR1 domain containing 1 -2.02833
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa -2.01104