CRCGN013_HEPG2_24H:P06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disulfiram 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN013_HEPG2_24H:P06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 4.8198
SQOR sulfide quinone oxidoreductase 4.37415
SATB1 SATB homeobox 1 4.36093
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.96614
ANO1 anoctamin 1, calcium activated chloride channel 3.73856
CARMIL1 capping protein regulator and myosin 1 linker 1 3.69182
DENND2D DENN/MADD domain containing 2D 3.41607
ABHD6 abhydrolase domain containing 6 3.34121
SSBP2 single-stranded DNA binding protein 2 3.15275
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.06037
CTSL cathepsin L 2.842
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.77293
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.76452
ADAT1 adenosine deaminase, tRNA-specific 1 2.74771
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.66913
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.64403
E2F2 E2F transcription factor 2 2.58455
CYCS cytochrome c, somatic 2.46348
GPER1 G protein-coupled estrogen receptor 1 2.4507
PRR15L proline rich 15-like 2.44433
GATA3 GATA binding protein 3 2.37399
NOSIP nitric oxide synthase interacting protein 2.33603
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.28303
HLA-DMA major histocompatibility complex, class II, DM alpha 2.00581

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -4.77373
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.75218
CCDC86 coiled-coil domain containing 86 -4.54774
LDHD lactate dehydrogenase D -4.3715
NUP93 nucleoporin 93kDa -3.79982
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.38262
C2CD5 C2 calcium-dependent domain containing 5 -3.079
YME1L1 YME1-like 1 ATPase -3.06651
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.80186
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.56853
DERA deoxyribose-phosphate aldolase (putative) -2.41358
TLCD3A TLC domain containing 3A -2.37423
EXT1 exostosin glycosyltransferase 1 -2.16934
PEG10 paternally expressed 10 -2.09332
ERI3 ERI1 exoribonuclease family member 3 -2.04748
PAK1IP1 PAK1 interacting protein 1 -2.03715
FGF17 fibroblast growth factor 17 -2.00676
MALT1 MALT1 paracaspase -2.00561