CRCGN013_HEPG2_24H:P08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nickel (ii) sulfate hexahydrate 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN013_HEPG2_24H:P08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 8.10713
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.4845
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 4.54963
AMDHD2 amidohydrolase domain containing 2 4.36154
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.89415
NOTCH1 notch 1 3.88306
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.70134
GSTZ1 glutathione S-transferase zeta 1 3.66413
CARMIL1 capping protein regulator and myosin 1 linker 1 3.55257
EPHA3 EPH receptor A3 3.48399
CTSL cathepsin L 2.92429
NOSIP nitric oxide synthase interacting protein 2.70534
GPATCH8 G patch domain containing 8 2.60505
SFTPB surfactant protein B 2.59817
CCDC85B coiled-coil domain containing 85B 2.38595
HLA-DMA major histocompatibility complex, class II, DM alpha 2.34574
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.31778
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.25096
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.2123
CHN1 chimerin 1 2.19791
LCN2 lipocalin 2 2.0999
TIAM1 T-cell lymphoma invasion and metastasis 1 2.06097

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.72839
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.94478
ZNF586 zinc finger protein 586 -6.71186
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.03046
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.38333
VAT1 vesicle amine transport 1 -4.33305
CD320 CD320 molecule -3.91342
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.81318
PUF60 poly-U binding splicing factor 60KDa -3.6605
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.57019
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.44358
MAP7 microtubule-associated protein 7 -3.42759
GNAS GNAS complex locus -2.97835
OXA1L oxidase (cytochrome c) assembly 1-like -2.97419
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.92223
CCNB2 cyclin B2 -2.87202
PEG10 paternally expressed 10 -2.76832
MAPK13 mitogen-activated protein kinase 13 -2.69855
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.63981
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.257
ZNF134 zinc finger protein 134 -2.21952
LAP3 leucine aminopeptidase 3 -2.21789
CAB39 calcium binding protein 39 -2.17701
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.15828
PPT2 palmitoyl-protein thioesterase 2 -2.05572
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.05132
FOLR3 folate receptor 3 (gamma) -2.00769