CRCGN013_HEPG2_24H:P10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nickel (ii) sulfate hexahydrate 2.48 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN013_HEPG2_24H:P10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 6.26461
STK10 serine/threonine kinase 10 5.03783
CXCR4 chemokine (C-X-C motif) receptor 4 3.98203
INTS3 integrator complex subunit 3 3.97364
UBQLN2 ubiquilin 2 3.82309
RRAGA Ras-related GTP binding A 3.70818
TBP TATA box binding protein 3.67499
LCN2 lipocalin 2 3.52794
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.52722
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.36166
CIAO3 cytosolic iron-sulfur assembly component 3 3.26744
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 3.24634
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.11988
EGF epidermal growth factor 2.84461
ABHD6 abhydrolase domain containing 6 2.82717
STXBP2 syntaxin binding protein 2 2.6662
CCNF cyclin F 2.65808
HLA-DRA major histocompatibility complex, class II, DR alpha 2.57154
GPER1 G protein-coupled estrogen receptor 1 2.51181
GSTZ1 glutathione S-transferase zeta 1 2.38915
PNKP polynucleotide kinase 3'-phosphatase 2.36317
PNPLA6 patatin-like phospholipase domain containing 6 2.23022
SPG11 spastic paraplegia 11 (autosomal recessive) 2.20197
MCUR1 mitochondrial calcium uniporter regulator 1 2.144
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.14249
JADE3 jade family PHD finger 3 2.14007
SNX7 sorting nexin 7 2.0907
CYCS cytochrome c, somatic 2.08156
PDLIM1 PDZ and LIM domain 1 2.06861

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
PCNA proliferating cell nuclear antigen -5.95217
OXA1L oxidase (cytochrome c) assembly 1-like -5.53875
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.92727
GNAS GNAS complex locus -4.87171
CCNB1 cyclin B1 -4.25943
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.1215
NT5DC2 5'-nucleotidase domain containing 2 -3.84898
ZNF586 zinc finger protein 586 -3.70365
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.57332
TXNDC9 thioredoxin domain containing 9 -3.05975
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.00397
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.94757
CCNB2 cyclin B2 -2.92432
ITGB1BP1 integrin beta 1 binding protein 1 -2.85942
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.80633
CDC20 cell division cycle 20 -2.76775
NSG2 neuronal vesicle trafficking associated 2 -2.7377
CIRBP cold inducible RNA binding protein -2.64585
SLC35F2 solute carrier family 35, member F2 -2.64028
THAP11 THAP domain containing 11 -2.46891
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.45595
MRPL15 mitochondrial ribosomal protein L15 -2.4318
NPAP1 nuclear pore associated protein 1 -2.42745
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 -2.39393
MYOC myocilin, trabecular meshwork inducible glucocorticoid response -2.37479
TCTN1 tectonic family member 1 -2.33573
MAB21L2 mab-21-like 2 (C. elegans) -2.30814
RXRG retinoid X receptor, gamma -2.29773
CRX cone-rod homeobox -2.21392
MT1F metallothionein 1F -2.18502
TRIM45 tripartite motif containing 45 -2.18466
SCN2B sodium channel, voltage gated, type II beta subunit -2.17916
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 -2.16461
SULT4A1 sulfotransferase family 4A, member 1 -2.14469
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.10171
CAB39 calcium binding protein 39 -2.08597
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -2.08293
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -2.08012
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.06364
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) -2.0203
NRIP1 nuclear receptor interacting protein 1 -2.01993
CST8 cystatin 8 (cystatin-related epididymal specific) -2.00746