CRCGN013_HEPG2_24H:P11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nickel (ii) sulfate hexahydrate 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN013_HEPG2_24H:P11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.72684
CCDC92 coiled-coil domain containing 92 5.37833
LOC122526780 uncharacterized LOC122526780 4.10411
SFTPB surfactant protein B 3.91428
HSPA1A heat shock 70kDa protein 1A 3.56132
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.50173
FPGS folylpolyglutamate synthase 3.06588
RAB31 RAB31, member RAS oncogene family 2.36248
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.26895
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.24016
NUP133 nucleoporin 133kDa 2.18323
NUDC nudC nuclear distribution protein 2.04069
BIRC2 baculoviral IAP repeat containing 2 2.0299
RBKS ribokinase 2.02393

decreased expression

Symbol Name Standardized Value
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -6.72166
KDM3A lysine (K)-specific demethylase 3A -4.70897
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.66023
LDHD lactate dehydrogenase D -4.60463
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.44608
ARID5B AT rich interactive domain 5B (MRF1-like) -4.17361
TUBB6 tubulin, beta 6 class V -4.17254
EGF epidermal growth factor -4.15924
PEG10 paternally expressed 10 -3.98772
MAPK13 mitogen-activated protein kinase 13 -3.6555
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.64949
CCNB2 cyclin B2 -3.59934
COG7 component of oligomeric golgi complex 7 -3.38934
ZNF586 zinc finger protein 586 -3.33099
DCK deoxycytidine kinase -2.97618
CTSD cathepsin D -2.69869
CCNB1 cyclin B1 -2.6381
RAI14 retinoic acid induced 14 -2.63568
TLR4 toll-like receptor 4 -2.5317
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.46762
MAP7 microtubule-associated protein 7 -2.40209
CCDC88C coiled-coil domain containing 88C -2.32446
CASP5 caspase 5, apoptosis-related cysteine peptidase -2.28102
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.26868
CRABP2 cellular retinoic acid binding protein 2 -2.24313
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) -2.20012
TLR1 toll-like receptor 1 -2.19666
EXT1 exostosin glycosyltransferase 1 -2.19235
IPP intracisternal A particle-promoted polypeptide -2.17801
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 -2.16753
ZNF362 zinc finger protein 362 -2.15743
EHF ets homologous factor -2.13018
EPN3 epsin 3 -2.1178
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.11381
CR2 complement component (3d/Epstein Barr virus) receptor 2 -2.1091
DBF4B DBF4 zinc finger B -2.10146
HOXD9 homeobox D9 -2.06332
CLEC4A C-type lectin domain family 4, member A -2.04041
RGS9BP regulator of G protein signaling 9 binding protein -2.03617
ZNF750 zinc finger protein 750 -2.01469
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.01078
THSD4 thrombospondin, type I, domain containing 4 -2.00649
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.00467
IFT70A intraflagellar transport 70A -2.00153