CRCGN013_HEPG2_24H:P12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nickel (ii) sulfate hexahydrate 0.62 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN013_HEPG2_24H:P12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 4.50672
LCN2 lipocalin 2 3.82474
CCL2 chemokine (C-C motif) ligand 2 3.4484
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.44614
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.27156
PNKP polynucleotide kinase 3'-phosphatase 3.21221
MSRA methionine sulfoxide reductase A 2.95806
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.67323
ARID4B AT rich interactive domain 4B (RBP1-like) 2.28224
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.08965

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.65751
GNAS GNAS complex locus -5.03279
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.97313
EDN1 endothelin 1 -3.08541
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.02577
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.95196
THAP11 THAP domain containing 11 -2.92703
TLR4 toll-like receptor 4 -2.58229
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.49609
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.31745
TENM3 teneurin transmembrane protein 3 -2.25492
HLA-DMA major histocompatibility complex, class II, DM alpha -2.1791
MAP7 microtubule-associated protein 7 -2.16139
IQSEC2 IQ motif and Sec7 domain 2 -2.09319
ALOX5 arachidonate 5-lipoxygenase -2.07636
HMG20B high mobility group 20B -2.04737
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.02687
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.01045
NTSR2 neurotensin receptor 2 -2.0023