CRCGN013_HEPG2_24H:P16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methoxychlor 2.53 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN013_HEPG2_24H:P16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.14829
LOC122526780 uncharacterized LOC122526780 5.35168
UBQLN2 ubiquilin 2 4.76725
CHN1 chimerin 1 4.70139
PPARG peroxisome proliferator-activated receptor gamma 4.69461
CCL2 chemokine (C-C motif) ligand 2 4.6385
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.51029
GPATCH8 G patch domain containing 8 3.35571
BPHL biphenyl hydrolase-like (serine hydrolase) 3.19908
RPL39L ribosomal protein L39-like 3.10463
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.85515
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.85414
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.72779
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.6
LAGE3 L antigen family, member 3 2.58516
MAP7 microtubule-associated protein 7 2.50614
LPAR2 lysophosphatidic acid receptor 2 2.24279
ADGRE5 adhesion G protein-coupled receptor E5 2.22624
PARP2 poly (ADP-ribose) polymerase 2 2.18999
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.13234
UFM1 ubiquitin-fold modifier 1 2.01445

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.23527
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.52225
UBE3C ubiquitin protein ligase E3C -5.23157
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.81228
TLCD3A TLC domain containing 3A -4.38316
GNAS GNAS complex locus -3.5056
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.15836
ZDHHC6 zinc finger, DHHC-type containing 6 -2.86096
CCDC86 coiled-coil domain containing 86 -2.7827
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.69707
CDC20 cell division cycle 20 -2.50056
CCP110 centriolar coiled coil protein 110kDa -2.36839
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.30321
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.28807
EIF5 eukaryotic translation initiation factor 5 -2.12625
CCNB2 cyclin B2 -2.09818
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.0638
RPS5 ribosomal protein S5 -2.03671
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.00909