CRCGN013_HEPG2_24H:P18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methoxychlor 0.63 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN013_HEPG2_24H:P18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.59174
MAMLD1 mastermind-like domain containing 1 4.63272
LCN2 lipocalin 2 4.62013
CIAO3 cytosolic iron-sulfur assembly component 3 4.13271
E2F2 E2F transcription factor 2 3.71093
CHN1 chimerin 1 3.67682
CARMIL1 capping protein regulator and myosin 1 linker 1 3.43779
ADRB2 adrenoceptor beta 2, surface 3.15869
ADAT1 adenosine deaminase, tRNA-specific 1 3.11019
ABHD6 abhydrolase domain containing 6 2.87583
SFTPB surfactant protein B 2.84606
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.69081
USP6NL USP6 N-terminal like 2.54132
CTSL cathepsin L 2.38723
GPATCH8 G patch domain containing 8 2.37479
TBP TATA box binding protein 2.36071
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.15321
NUP133 nucleoporin 133kDa 2.11354
GSTZ1 glutathione S-transferase zeta 1 2.069
TIAM1 T-cell lymphoma invasion and metastasis 1 2.06378

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -4.54066
ZNF586 zinc finger protein 586 -4.43826
OXA1L oxidase (cytochrome c) assembly 1-like -4.20367
CDC20 cell division cycle 20 -3.88811
VAT1 vesicle amine transport 1 -3.88421
COG7 component of oligomeric golgi complex 7 -3.79191
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.12779
CCNB1 cyclin B1 -3.1051
DUSP6 dual specificity phosphatase 6 -2.88999
TLR4 toll-like receptor 4 -2.74361
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.65417
CTSD cathepsin D -2.52716
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.3974
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -2.33186
FBXO7 F-box protein 7 -2.32065
SAV1 salvador family WW domain containing protein 1 -2.19893
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 -2.14837
TCEAL4 transcription elongation factor A (SII)-like 4 -2.14477
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -2.12115
AGTR1 angiotensin II receptor, type 1 -2.09431
ZNF208 zinc finger protein 208 -2.06907
ZNF134 zinc finger protein 134 -2.02207