CRCGN013_HEPG2_24H:P23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 2.47 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN013_HEPG2_24H:P23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIAM1 T-cell lymphoma invasion and metastasis 1 4.86394
SSBP2 single-stranded DNA binding protein 2 4.83089
SFTPB surfactant protein B 3.6728
MAMLD1 mastermind-like domain containing 1 3.44718
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.42991
STIMATE STIM activating enhancer 3.31071
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.26974
LCN2 lipocalin 2 2.82953
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.64269
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.52389
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 2.39164
TBL1X transducin (beta)-like 1X-linked 2.36376
ADAM10 ADAM metallopeptidase domain 10 2.31009
RRAGA Ras-related GTP binding A 2.30267
SHB Src homology 2 domain containing adaptor protein B 2.28359
SNX7 sorting nexin 7 2.27217
SOCS2 suppressor of cytokine signaling 2 2.23389
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.16032
TREM1 triggering receptor expressed on myeloid cells 1 2.13203
CCNF cyclin F 2.12716
KDM5A lysine (K)-specific demethylase 5A 2.10611
DIPK1A divergent protein kinase domain 1A 2.09522
PRKCD protein kinase C, delta 2.07075

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.08765
PECR peroxisomal trans-2-enoyl-CoA reductase -5.89062
OXA1L oxidase (cytochrome c) assembly 1-like -5.11771
SCAND1 SCAN domain containing 1 -4.81503
GTPBP8 GTP-binding protein 8 (putative) -4.45507
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.39322
CRELD2 cysteine-rich with EGF-like domains 2 -3.82491
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.7976
DERA deoxyribose-phosphate aldolase (putative) -3.78596
TLCD3A TLC domain containing 3A -3.50805
CDC20 cell division cycle 20 -3.47687
RAI14 retinoic acid induced 14 -3.38215
PCCB propionyl CoA carboxylase, beta polypeptide -3.28655
UGDH UDP-glucose 6-dehydrogenase -3.05788
LDHD lactate dehydrogenase D -3.05562
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.91988
DCK deoxycytidine kinase -2.4588
MTA1 metastasis associated 1 -2.39406
GRB7 growth factor receptor-bound protein 7 -2.38427
CAB39 calcium binding protein 39 -2.3242
EAPP E2F-associated phosphoprotein -2.29349
TSSC4 tumor suppressing subtransferable candidate 4 -2.23903
PGLS 6-phosphogluconolactonase -2.2064
RECK reversion-inducing-cysteine-rich protein with kazal motifs -2.20519
CCP110 centriolar coiled coil protein 110kDa -2.18339
FGL2 fibrinogen-like 2 -2.16534
CDHR1 cadherin-related family member 1 -2.15065
ZMIZ1 zinc finger, MIZ-type containing 1 -2.14155
LIMA1 LIM domain and actin binding 1 -2.11388
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.10988
SPA17 sperm autoantigenic protein 17 -2.03769
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.03219
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.0294
ZBTB32 zinc finger and BTB domain containing 32 -2.01824
L1TD1 LINE-1 type transposase domain containing 1 -2.00252
TLR4 toll-like receptor 4 -2.00096