CRCGN013_HEPG2_24H:P24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN013_HEPG2_24H:P24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 4.65579
GPER1 G protein-coupled estrogen receptor 1 4.422
HLA-DMA major histocompatibility complex, class II, DM alpha 4.31927
ADRB2 adrenoceptor beta 2, surface 4.2889
E2F2 E2F transcription factor 2 4.06048
LCN2 lipocalin 2 4.04142
CCL2 chemokine (C-C motif) ligand 2 3.99767
CHMP6 charged multivesicular body protein 6 3.85828
LOC122526780 uncharacterized LOC122526780 3.65532
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.57676
LYN LYN proto-oncogene, Src family tyrosine kinase 3.57078
CCNA1 cyclin A1 3.51156
EAPP E2F-associated phosphoprotein 3.39477
PFKL phosphofructokinase, liver 3.32841
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.28056
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.19534
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.11778
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.10411
PEX11A peroxisomal biogenesis factor 11 alpha 3.00104
SLC75A1 solute carrier family 75 member 1 2.92645
CDK6 cyclin-dependent kinase 6 2.89599
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.71286
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.69379
CNN1 calponin 1, basic, smooth muscle 2.61848
BAX BCL2-associated X protein 2.61248
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.49873
CCNF cyclin F 2.49022
HLA-DRA major histocompatibility complex, class II, DR alpha 2.4782
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.42034
FKBP14 FK506 binding protein 14, 22 kDa 2.41717
EGF epidermal growth factor 2.41091
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 2.37393
GSTZ1 glutathione S-transferase zeta 1 2.33548
RRAGA Ras-related GTP binding A 2.3197
EIF3B eukaryotic translation initiation factor 3, subunit B 2.29233
FOXO4 forkhead box O4 2.27911
ACOX2 acyl-CoA oxidase 2, branched chain 2.22722
LRP10 low density lipoprotein receptor-related protein 10 2.22722
JADE2 jade family PHD finger 2 2.20936
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.14846
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.09411
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.08383
CARMIL1 capping protein regulator and myosin 1 linker 1 2.02433
XK X-linked Kx blood group 2.01575
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 2.00804
MDN1 MDN1, midasin homolog (yeast) 2.00512
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 2.00467

decreased expression

Symbol Name Standardized Value
RAI14 retinoic acid induced 14 -5.13104
KDM3A lysine (K)-specific demethylase 3A -5.06038
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.78869
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.40576
TRIB3 tribbles pseudokinase 3 -4.3168
GNAS GNAS complex locus -4.26181
TP53BP2 tumor protein p53 binding protein 2 -4.07626
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.9839
CCDC86 coiled-coil domain containing 86 -3.93272
ADI1 acireductone dioxygenase 1 -3.91873
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.65723
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.65161
VAT1 vesicle amine transport 1 -3.65137
CCNB2 cyclin B2 -3.42541
COG7 component of oligomeric golgi complex 7 -2.75756
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.6348
PRKCQ protein kinase C, theta -2.56005
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.55396
CCNB1 cyclin B1 -2.46207
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.40956
OXA1L oxidase (cytochrome c) assembly 1-like -2.22725
DDIT4 DNA-damage-inducible transcript 4 -2.21543
CCP110 centriolar coiled coil protein 110kDa -2.21355
TCEAL4 transcription elongation factor A (SII)-like 4 -2.20092
NECAP2 NECAP endocytosis associated 2 -2.0973
RND3 Rho family GTPase 3 -2.06778
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.02606
MNT MAX network transcriptional repressor -2.02513
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.02493
TRIM8 tripartite motif containing 8 -2.01992