CRCGN014_HEPG2_24H:A05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methotrexate 20.68 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

306 genes differentially expressed following the CRCGN014_HEPG2_24H:A05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.55651
KIFBP kinesin family binding protein 6.4445
UBQLN2 ubiquilin 2 6.20997
CDPF1 cysteine-rich, DPF motif domain containing 1 5.81367
INPP1 inositol polyphosphate-1-phosphatase 5.68644
IGFBP3 insulin-like growth factor binding protein 3 5.17836
TUBB6 tubulin, beta 6 class V 5.13379
GATA3 GATA binding protein 3 5.07322
CARMIL1 capping protein regulator and myosin 1 linker 1 4.88921
TIMP2 TIMP metallopeptidase inhibitor 2 4.67008
IER3 immediate early response 3 4.61758
S100A4 S100 calcium binding protein A4 4.54181
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.28258
ACOT9 acyl-CoA thioesterase 9 4.27307
GLRX glutaredoxin (thioltransferase) 3.99836
MVP major vault protein 3.91233
NPDC1 neural proliferation, differentiation and control, 1 3.88112
DUSP6 dual specificity phosphatase 6 3.81748
CDC45 cell division cycle 45 3.77134
PPARG peroxisome proliferator-activated receptor gamma 3.59745
BPHL biphenyl hydrolase-like (serine hydrolase) 3.58198
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.55665
MSRA methionine sulfoxide reductase A 3.53342
KHDC4 KH domain containing 4, pre-mRNA splicing factor 3.50176
DDB2 damage-specific DNA binding protein 2, 48kDa 3.49168
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.48199
ZNF589 zinc finger protein 589 3.43354
PRR15L proline rich 15-like 3.42292
CNPY3 canopy FGF signaling regulator 3 3.37173
GPER1 G protein-coupled estrogen receptor 1 3.2748
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.23
CHN1 chimerin 1 3.15869
C2CD2 C2 calcium-dependent domain containing 2 3.15668
ADRB2 adrenoceptor beta 2, surface 3.15114
DYNLT3 dynein, light chain, Tctex-type 3 3.10292
STK10 serine/threonine kinase 10 3.07031
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.06242
MICALL1 MICAL-like 1 2.98635
GAK cyclin G associated kinase 2.98598
MST1R macrophage stimulating 1 receptor 2.93419
ITGB5 integrin, beta 5 2.9192
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.90939
ZNF212 zinc finger protein 212 2.89712
MLPH melanophilin 2.89047
CCP110 centriolar coiled coil protein 110kDa 2.86061
CYCS cytochrome c, somatic 2.83913
SCRN1 secernin 1 2.83443
LAP3 leucine aminopeptidase 3 2.81652
ANO10 anoctamin 10 2.8157
TMEM50A transmembrane protein 50A 2.81451
CBR3 carbonyl reductase 3 2.79249
HDGFL3 HDGF like 3 2.77233
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.77113
TERF2IP telomeric repeat binding factor 2, interacting protein 2.76504
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.76474
GATA2 GATA binding protein 2 2.75552
SPAG7 sperm associated antigen 7 2.74981
PRPF39 pre-mRNA processing factor 39 2.74372
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.7283
EDN1 endothelin 1 2.71088
MAP7 microtubule-associated protein 7 2.6892
TRIB1 tribbles pseudokinase 1 2.61817
BECN1 beclin 1, autophagy related 2.6121
UFM1 ubiquitin-fold modifier 1 2.59081
NPC1 Niemann-Pick disease, type C1 2.57309
E2F2 E2F transcription factor 2 2.55198
BLCAP bladder cancer associated protein 2.53401
KEAP1 kelch-like ECH-associated protein 1 2.5329
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.51935
CDK7 cyclin-dependent kinase 7 2.5179
MTCL1 microtubule crosslinking factor 1 2.49539
SRPX sushi-repeat containing protein, X-linked 2.49171
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.48004
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 2.47673
PRPF38B pre-mRNA processing factor 38B 2.47263
AMDHD2 amidohydrolase domain containing 2 2.45749
GREM1 gremlin 1, DAN family BMP antagonist 2.45407
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.43197
SLC75A1 solute carrier family 75 member 1 2.4268
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.40462
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.40443
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.38998
STK25 serine/threonine kinase 25 2.36029
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.34758
SQOR sulfide quinone oxidoreductase 2.33901
NISCH nischarin 2.32446
CASC3 cancer susceptibility candidate 3 2.32245
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.31564
GOLT1B golgi transport 1B 2.31176
SOX4 SRY (sex determining region Y)-box 4 2.30044
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 2.30014
S100A13 S100 calcium binding protein A13 2.29706
AGTR1 angiotensin II receptor, type 1 2.29052
SMAD3 SMAD family member 3 2.28685
EPHB2 EPH receptor B2 2.26727
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.25521
CD8A CD8a molecule 2.24756
CSNK1E casein kinase 1, epsilon 2.23378
TMEM74B transmembrane protein 74B 2.23228
FBN1 fibrillin 1 2.23203
BATF basic leucine zipper transcription factor, ATF-like 2.2189
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.21523
CYTH1 cytohesin 1 2.21272
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.20571
DUSP4 dual specificity phosphatase 4 2.2054
LGALS8 lectin, galactoside-binding, soluble, 8 2.20363
PTCRA pre T-cell antigen receptor alpha 2.20123
INPP5J inositol polyphosphate-5-phosphatase J 2.20055
IL4R interleukin 4 receptor 2.20028
GPATCH8 G patch domain containing 8 2.18749
WDR44 WD repeat domain 44 2.18175
DUSP8 dual specificity phosphatase 8 2.17714
MAEA macrophage erythroblast attacher 2.16571
CUL7 cullin 7 2.15746
ATG2B autophagy related 2B 2.15688
ARHGAP24 Rho GTPase activating protein 24 2.15028
PARP3 poly (ADP-ribose) polymerase family, member 3 2.15028
MCOLN1 mucolipin 1 2.14577
DCTN1 dynactin 1 2.13867
UBL3 ubiquitin-like 3 2.1311
MBNL1 muscleblind-like splicing regulator 1 2.12933
MED23 mediator complex subunit 23 2.12766
MED15 mediator complex subunit 15 2.12351
MGLL monoglyceride lipase 2.11665
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.11414
KLRC4-KLRK1 KLRC4-KLRK1 readthrough 2.11298
UBR2 ubiquitin protein ligase E3 component n-recognin 2 2.10306
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2.09762
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 2.09669
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2.09493
PTH1R parathyroid hormone 1 receptor 2.09485
PRKCH protein kinase C, eta 2.09371
PNISR PNN-interacting serine/arginine-rich protein 2.08954
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.08904
CEPT1 choline/ethanolamine phosphotransferase 1 2.08175
FILIP1L filamin A interacting protein 1-like 2.06786
TACC2 transforming, acidic coiled-coil containing protein 2 2.06667
FBXO7 F-box protein 7 2.05913
CDC25B cell division cycle 25B 2.05254
SQSTM1 sequestosome 1 2.04772
LIMA1 LIM domain and actin binding 1 2.0473
SNAP25 synaptosomal-associated protein, 25kDa 2.04496
TBC1D2B TBC1 domain family, member 2B 2.03968
JADE2 jade family PHD finger 2 2.03334
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.02988
C1QTNF3 C1q and tumor necrosis factor related protein 3 2.0267
TRAK1 trafficking protein, kinesin binding 1 2.02019
CYBRD1 cytochrome b reductase 1 2.01977
MAP3K6 mitogen-activated protein kinase kinase kinase 6 2.00518
TSC1 tuberous sclerosis 1 2.00419

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -6.04185
CHMP4B charged multivesicular body protein 4B -5.6362
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.41717
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -5.25261
NIT1 nitrilase 1 -5.2484
PSRC1 proline/serine-rich coiled-coil 1 -4.97761
PLK1 polo-like kinase 1 -4.92793
PECR peroxisomal trans-2-enoyl-CoA reductase -4.75956
RXYLT1 ribitol xylosyltransferase 1 -4.70692
ISOC1 isochorismatase domain containing 1 -4.67424
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.49086
NLRP2B NLR family pyrin domain containing 2B -4.46752
TCTN1 tectonic family member 1 -4.42142
RUVBL1 RuvB-like AAA ATPase 1 -4.40402
UBE2C ubiquitin-conjugating enzyme E2C -4.39359
NT5DC2 5'-nucleotidase domain containing 2 -4.29636
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.97743
DDIT4 DNA-damage-inducible transcript 4 -3.94862
CCNB1 cyclin B1 -3.94116
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -3.93388
TRIB3 tribbles pseudokinase 3 -3.91989
LAGE3 L antigen family, member 3 -3.90941
THAP11 THAP domain containing 11 -3.86635
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.84009
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.82746
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.76585
CCDC86 coiled-coil domain containing 86 -3.76393
LBR lamin B receptor -3.67631
TOP2A topoisomerase (DNA) II alpha 170kDa -3.62057
HYOU1 hypoxia up-regulated 1 -3.58091
NCAPD2 non-SMC condensin I complex, subunit D2 -3.5251
CCNA2 cyclin A2 -3.50539
PUF60 poly-U binding splicing factor 60KDa -3.50214
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.43839
ADI1 acireductone dioxygenase 1 -3.41277
MRPL58 mitochondrial ribosomal protein L58 -3.39538
SLC35F2 solute carrier family 35, member F2 -3.39272
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.3834
SOAT2 sterol O-acyltransferase 2 -3.37739
NUP85 nucleoporin 85kDa -3.36184
PEG10 paternally expressed 10 -3.32848
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.32436
RPS5 ribosomal protein S5 -3.31848
C5 complement component 5 -3.31633
ANKRD10 ankyrin repeat domain 10 -3.3125
PYCR1 pyrroline-5-carboxylate reductase 1 -3.26274
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -3.23743
CRELD2 cysteine-rich with EGF-like domains 2 -3.22111
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -3.20884
RPP38 ribonuclease P/MRP 38kDa subunit -3.194
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.16763
RPIA ribose 5-phosphate isomerase A -3.15694
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.13237
ICAM3 intercellular adhesion molecule 3 -3.11653
BIRC5 baculoviral IAP repeat containing 5 -3.11451
ACAA1 acetyl-CoA acyltransferase 1 -3.05447
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.05317
PAAF1 proteasomal ATPase-associated factor 1 -3.01645
TOMM70 translocase of outer mitochondrial membrane 70 -2.99787
FASTKD5 FAST kinase domains 5 -2.93779
RFC2 replication factor C (activator 1) 2, 40kDa -2.92517
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.90124
HEBP1 heme binding protein 1 -2.89361
GTPBP8 GTP-binding protein 8 (putative) -2.85458
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.85231
MELK maternal embryonic leucine zipper kinase -2.84761
RIDA reactive intermediate imine deaminase A homolog -2.83909
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -2.82182
CCDC85B coiled-coil domain containing 85B -2.82074
PEX11A peroxisomal biogenesis factor 11 alpha -2.80563
CDK1 cyclin-dependent kinase 1 -2.78154
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.77795
AURKB aurora kinase B -2.7535
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.66646
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.6544
CHMP6 charged multivesicular body protein 6 -2.65435
ZW10 zw10 kinetochore protein -2.6145
TP53RK TP53 regulating kinase -2.60513
NENF neudesin neurotrophic factor -2.59947
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.57302
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.55535
ARHGAP1 Rho GTPase activating protein 1 -2.52579
RUVBL2 RuvB-like AAA ATPase 2 -2.52256
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.44293
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.43863
ZNF16 zinc finger protein 16 -2.43629
COG4 component of oligomeric golgi complex 4 -2.43478
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.41344
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.39743
ECH1 enoyl CoA hydratase 1, peroxisomal -2.3965
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.39391
MRPS7 mitochondrial ribosomal protein S7 -2.37947
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.37063
PPID peptidylprolyl isomerase D -2.35743
SAP30BP SAP30 binding protein -2.32462
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -2.32186
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.31821
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.30643
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.29746
YME1L1 YME1-like 1 ATPase -2.28612
PIMREG PICALM interacting mitotic regulator -2.28123
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -2.28053
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -2.27951
HMGN1 high mobility group nucleosome binding domain 1 -2.27841
INHBE inhibin, beta E -2.27172
HMGN2 high mobility group nucleosomal binding domain 2 -2.26575
CBR1 carbonyl reductase 1 -2.24315
ZNF32 zinc finger protein 32 -2.23531
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.22978
CCNB2 cyclin B2 -2.22596
TRMT5 tRNA methyltransferase 5 -2.22247
MYL9 myosin, light chain 9, regulatory -2.21959
TBC1D31 TBC1 domain family, member 31 -2.20768
ATP5PD ATP synthase peripheral stalk subunit d -2.20459
LIAS lipoic acid synthetase -2.20441
H2AX H2A.X variant histone -2.20117
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -2.19828
HSPA14 heat shock 70kDa protein 14 -2.18368
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.16677
PGAP2 post-GPI attachment to proteins 2 -2.16212
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -2.15487
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.15115
TMED9 transmembrane emp24 protein transport domain containing 9 -2.14612
HMOX1 heme oxygenase 1 -2.14595
NME5 NME/NM23 family member 5 -2.1397
INTS8 integrator complex subunit 8 -2.13179
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.13168
CETN3 centrin, EF-hand protein, 3 -2.10668
MRPL11 mitochondrial ribosomal protein L11 -2.10641
CDKN3 cyclin-dependent kinase inhibitor 3 -2.10344
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) -2.10006
DBF4 DBF4 zinc finger -2.07751
GRB2 growth factor receptor-bound protein 2 -2.074
ORC3 origin recognition complex, subunit 3 -2.0705
NR1H4 nuclear receptor subfamily 1, group H, member 4 -2.05618
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.05436
GLDC glycine dehydrogenase (decarboxylating) -2.0525
DNAAF5 dynein, axonemal, assembly factor 5 -2.04889
GEMIN6 gem (nuclear organelle) associated protein 6 -2.04392
DHCR7 7-dehydrocholesterol reductase -2.04316
CDCA3 cell division cycle associated 3 -2.04247
MPZL2 myelin protein zero-like 2 -2.04127
NUBPL nucleotide binding protein-like -2.03996
HAT1 histone acetyltransferase 1 -2.03896
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.02935
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.02369
PHB2 prohibitin 2 -2.02277
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.01967
RBBP9 retinoblastoma binding protein 9 -2.01949
CDK4 cyclin-dependent kinase 4 -2.0176
SPA17 sperm autoantigenic protein 17 -2.01367
SNRPE small nuclear ribonucleoprotein polypeptide E -2.01211
CEP112 centrosomal protein 112kDa -2.01087
TLR4 toll-like receptor 4 -2.00975
ZNF7 zinc finger protein 7 -2.00498
GCSH glycine cleavage system protein H (aminomethyl carrier) -2.00456