CRCGN014_HEPG2_24H:A10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description m-phenylenediamine.2hcl 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

336 genes differentially expressed following the CRCGN014_HEPG2_24H:A10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 8.50982
MSRA methionine sulfoxide reductase A 7.70368
CXCL2 chemokine (C-X-C motif) ligand 2 7.2734
CARMIL1 capping protein regulator and myosin 1 linker 1 7.03897
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 5.77249
GATA3 GATA binding protein 3 5.4641
LCN2 lipocalin 2 5.21
PNKP polynucleotide kinase 3'-phosphatase 5.08695
EAPP E2F-associated phosphoprotein 5.0706
AMDHD2 amidohydrolase domain containing 2 5.00057
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.97392
BLMH bleomycin hydrolase 4.77652
PRKCQ protein kinase C, theta 4.57067
PLS1 plastin 1 4.51902
CIAO3 cytosolic iron-sulfur assembly component 3 4.49747
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.48013
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.46833
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.26224
MOK MOK protein kinase 4.16753
E2F2 E2F transcription factor 2 4.13217
ADGRE5 adhesion G protein-coupled receptor E5 4.13084
PFKL phosphofructokinase, liver 4.08261
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.06223
EPHB2 EPH receptor B2 4.02767
HDGFL3 HDGF like 3 4.00295
CHMP6 charged multivesicular body protein 6 3.98999
KLHL21 kelch-like family member 21 3.98406
UBQLN2 ubiquilin 2 3.91429
VAV3 vav 3 guanine nucleotide exchange factor 3.82981
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.82002
KLHL9 kelch-like family member 9 3.77964
PMM2 phosphomannomutase 2 3.64954
DYNLT3 dynein, light chain, Tctex-type 3 3.58938
MICALL1 MICAL-like 1 3.56522
HLA-DMA major histocompatibility complex, class II, DM alpha 3.46527
PIH1D1 PIH1 domain containing 1 3.40352
MYLK myosin light chain kinase 3.14907
GALE UDP-galactose-4-epimerase 3.08509
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.02603
ANO1 anoctamin 1, calcium activated chloride channel 2.99586
PGPEP1 pyroglutamyl-peptidase I 2.97039
PLSCR1 phospholipid scramblase 1 2.92962
FZD7 frizzled class receptor 7 2.9267
INTS9 integrator complex subunit 9 2.82933
CRTAP cartilage associated protein 2.77915
ASXL2 additional sex combs like transcriptional regulator 2 2.77238
NANOS2 nanos homolog 2 (Drosophila) 2.75913
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.7111
STIMATE STIM activating enhancer 2.67403
CYCS cytochrome c, somatic 2.66151
OSGIN1 oxidative stress induced growth inhibitor 1 2.64814
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.63703
ABHD6 abhydrolase domain containing 6 2.61918
APOL1 apolipoprotein L, 1 2.58935
FOCAD focadhesin 2.5826
CPPED1 calcineurin-like phosphoesterase domain containing 1 2.57817
SLC35H1 solute carrier family 35 member H1 2.56275
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 2.5345
LOC122526780 uncharacterized LOC122526780 2.53045
GALK1 galactokinase 1 2.5259
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.51735
DRP2 dystrophin related protein 2 2.51542
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.50881
GLTP glycolipid transfer protein 2.50046
PRR15L proline rich 15-like 2.49776
GCDH glutaryl-CoA dehydrogenase 2.49459
TRMT61B tRNA methyltransferase 61B 2.49331
SMAD3 SMAD family member 3 2.48866
INCENP inner centromere protein antigens 135/155kDa 2.4873
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 2.47295
NUP133 nucleoporin 133kDa 2.4507
DENND4A DENN/MADD domain containing 4A 2.44773
SLC75A1 solute carrier family 75 member 1 2.44436
CHN1 chimerin 1 2.44434
AFTPH aftiphilin 2.43964
CDC25B cell division cycle 25B 2.43529
CCKBR cholecystokinin B receptor 2.42577
CBR1 carbonyl reductase 1 2.40536
CLCN7 chloride channel, voltage-sensitive 7 2.39791
IL3RA interleukin 3 receptor, alpha (low affinity) 2.39071
GADD45G growth arrest and DNA-damage-inducible, gamma 2.37962
MSRB1 methionine sulfoxide reductase B1 2.35601
DOC2B double C2-like domains, beta 2.34773
KIF5C kinesin family member 5C 2.34758
ATAD3A ATPase family, AAA domain containing 3A 2.34395
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.34127
CLBA1 clathrin binding box of aftiphilin containing 1 2.33787
SLC17A2 solute carrier family 17, member 2 2.3361
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 2.33472
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.33092
ADM2 adrenomedullin 2 2.32515
PKLR pyruvate kinase, liver and RBC 2.32206
MDM4 MDM4, p53 regulator 2.31844
FABP1 fatty acid binding protein 1, liver 2.31738
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.31087
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 2.3089
ANKFY1 ankyrin repeat and FYVE domain containing 1 2.29407
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 2.2938
COL5A1 collagen, type V, alpha 1 2.29184
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.28826
NCLN nicalin 2.28809
BHMT betaine--homocysteine S-methyltransferase 2.28709
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.28525
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.28189
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 2.28024
JRKL JRK-like 2.26998
AMN amnion associated transmembrane protein 2.26321
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.2559
MELTF melanotransferrin 2.24865
POMT2 protein-O-mannosyltransferase 2 2.24785
MED13 mediator complex subunit 13 2.24688
ARFRP1 ADP-ribosylation factor related protein 1 2.24645
ACSM2A acyl-CoA synthetase medium-chain family member 2A 2.24631
EYA3 EYA transcriptional coactivator and phosphatase 3 2.2368
ERBB4 erb-b2 receptor tyrosine kinase 4 2.23585
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.23147
KCTD17 potassium channel tetramerization domain containing 17 2.22759
TRIM25 tripartite motif containing 25 2.2245
GAST gastrin 2.22346
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.22285
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 2.22204
DLL3 delta-like 3 (Drosophila) 2.21884
GPR27 G protein-coupled receptor 27 2.21759
EMX1 empty spiracles homeobox 1 2.20914
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.20616
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.20384
IL2RG interleukin 2 receptor, gamma 2.20273
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.19823
TCF12 transcription factor 12 2.19732
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.19514
RAX retina and anterior neural fold homeobox 2.19358
KNG1 kininogen 1 2.19324
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 2.17485
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.17459
BCL7A B-cell CLL/lymphoma 7A 2.16311
THOC6 THO complex 6 2.15806
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.15794
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 2.15646
CFHR3 complement factor H-related 3 2.15532
KLF2 Kruppel-like factor 2 2.1515
CGB8 chorionic gonadotropin, beta polypeptide 8 2.15124
CKAP2 cytoskeleton associated protein 2 2.15098
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.15001
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.14539
PTPRD protein tyrosine phosphatase, receptor type, D 2.14538
PAAF1 proteasomal ATPase-associated factor 1 2.14455
EMID1 EMI domain containing 1 2.14413
ANKRD46 ankyrin repeat domain 46 2.14221
CPQ carboxypeptidase Q 2.13534
ATG2A autophagy related 2A 2.13378
AQP2 aquaporin 2 (collecting duct) 2.13295
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.12511
PGM1 phosphoglucomutase 1 2.12218
BAAT bile acid CoA:amino acid N-acyltransferase 2.12019
ACP6 acid phosphatase 6, lysophosphatidic 2.11861
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.11569
EPHA3 EPH receptor A3 2.1155
NKX2-8 NK2 homeobox 8 2.11425
MECOM MDS1 and EVI1 complex locus 2.11305
SYTL3 synaptotagmin-like 3 2.11277
MTM1 myotubularin 1 2.11206
FABP6 fatty acid binding protein 6, ileal 2.10907
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.10775
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.10463
BLCAP bladder cancer associated protein 2.09902
PRB3 proline-rich protein BstNI subfamily 3 2.09838
SYNRG synergin, gamma 2.09296
CCL24 chemokine (C-C motif) ligand 24 2.09241
SETD3 SET domain containing 3 2.08496
MCPH1 microcephalin 1 2.08195
SPTBN5 spectrin, beta, non-erythrocytic 5 2.07576
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.07562
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.07438
ZEB2 zinc finger E-box binding homeobox 2 2.07344
EVX1 even-skipped homeobox 1 2.0694
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.06726
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.06238
ITGA6 integrin, alpha 6 2.05985
GFER growth factor, augmenter of liver regeneration 2.05859
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.05526
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.0517
MATN1 matrilin 1, cartilage matrix protein 2.0499
CDADC1 cytidine and dCMP deaminase domain containing 1 2.04956
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.04837
SLC38A6 solute carrier family 38, member 6 2.04208
WRN Werner syndrome, RecQ helicase-like 2.03758
SV2A synaptic vesicle glycoprotein 2A 2.03458
CTIF CBP80/20-dependent translation initiation factor 2.03187
IRF2 interferon regulatory factor 2 2.03054
RANBP3 RAN binding protein 3 2.0293
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.0285
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.02681
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.02455
NPPA natriuretic peptide A 2.02349
DDHD2 DDHD domain containing 2 2.02021
GRK1 G protein-coupled receptor kinase 1 2.02007
HACL2 2-hydroxyacyl-CoA lyase 2 2.0199
PTPRT protein tyrosine phosphatase, receptor type, T 2.01961
ABR active BCR-related 2.01831
GPER1 G protein-coupled estrogen receptor 1 2.01674
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 2.01505
CLDN14 claudin 14 2.01135
GMDS GDP-mannose 4,6-dehydratase 2.00478
PARP3 poly (ADP-ribose) polymerase family, member 3 2.00374
MEIS2 Meis homeobox 2 2.00207
NOCT nocturnin 2.00192
RTEL1 regulator of telomere elongation helicase 1 2.00052

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.36128
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -7.65748
CDC20 cell division cycle 20 -7.43694
TSPAN4 tetraspanin 4 -7.39179
THAP11 THAP domain containing 11 -5.58934
KDM3A lysine (K)-specific demethylase 3A -5.39905
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.34681
DSG2 desmoglein 2 -5.20933
FBXL12 F-box and leucine-rich repeat protein 12 -5.19382
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -5.18541
VAT1 vesicle amine transport 1 -5.17313
NUP85 nucleoporin 85kDa -5.15844
GTPBP8 GTP-binding protein 8 (putative) -5.15392
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.10494
ACOT9 acyl-CoA thioesterase 9 -5.01143
PEG10 paternally expressed 10 -4.96671
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.9127
RPIA ribose 5-phosphate isomerase A -4.8972
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.88115
PLK1 polo-like kinase 1 -4.86512
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.81313
MRPS16 mitochondrial ribosomal protein S16 -4.7808
C2CD5 C2 calcium-dependent domain containing 5 -4.6454
ISOC1 isochorismatase domain containing 1 -4.59581
TRIB3 tribbles pseudokinase 3 -4.58815
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.56969
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.52575
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -4.51284
LAP3 leucine aminopeptidase 3 -4.44574
NCK1 NCK adaptor protein 1 -4.29285
DNM1L dynamin 1-like -4.19024
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.00476
ZDHHC6 zinc finger, DHHC-type containing 6 -3.98422
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.97064
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.93384
SCAND1 SCAN domain containing 1 -3.92885
CHMP4B charged multivesicular body protein 4B -3.83568
ZW10 zw10 kinetochore protein -3.81851
NGRN neugrin, neurite outgrowth associated -3.75918
TWF2 twinfilin actin binding protein 2 -3.71552
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.70217
MRPS2 mitochondrial ribosomal protein S2 -3.61766
ZNF586 zinc finger protein 586 -3.61441
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.51975
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.48097
TBCB tubulin folding cofactor B -3.42109
NVL nuclear VCP-like -3.40658
ZNF146 zinc finger protein 146 -3.40093
CAB39 calcium binding protein 39 -3.32828
LYPLA1 lysophospholipase I -3.29166
TES testin LIM domain protein -3.19219
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -3.17891
SLC35F2 solute carrier family 35, member F2 -3.1668
TM9SF3 transmembrane 9 superfamily member 3 -3.16284
DCK deoxycytidine kinase -3.13841
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.13116
PTPRK protein tyrosine phosphatase, receptor type, K -3.11449
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -3.03192
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.95004
CNBP CCHC-type zinc finger, nucleic acid binding protein -2.94838
PRDX4 peroxiredoxin 4 -2.73181
GNAS GNAS complex locus -2.69101
TOR1A torsin family 1, member A (torsin A) -2.6863
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.68432
TOMM34 translocase of outer mitochondrial membrane 34 -2.67259
EMC3 ER membrane protein complex subunit 3 -2.65796
CTSD cathepsin D -2.65684
PPCS phosphopantothenoylcysteine synthetase -2.56932
RPF1 ribosome production factor 1 homolog (S. cerevisiae) -2.55657
S100A14 S100 calcium binding protein A14 -2.5374
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.53512
HSPE1 heat shock 10kDa protein 1 -2.52813
ELOVL6 ELOVL fatty acid elongase 6 -2.51168
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.50203
CKLF-CMTM1 CKLF-CMTM1 readthrough -2.48863
GOLT1B golgi transport 1B -2.48503
YME1L1 YME1-like 1 ATPase -2.48229
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.45532
ADI1 acireductone dioxygenase 1 -2.44097
TLCD3A TLC domain containing 3A -2.43601
PSENEN presenilin enhancer gamma secretase subunit -2.42185
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.40173
JPT1 Jupiter microtubule associated homolog 1 -2.39408
EXOSC8 exosome component 8 -2.39274
LDHD lactate dehydrogenase D -2.38269
ZFAND1 zinc finger, AN1-type domain 1 -2.36312
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.36011
MYD88 myeloid differentiation primary response 88 -2.32631
IER3 immediate early response 3 -2.32303
GPR18 G protein-coupled receptor 18 -2.31133
NFU1 NFU1 iron-sulfur cluster scaffold -2.31111
CRABP1 cellular retinoic acid binding protein 1 -2.29615
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.28339
ATRAID all-trans retinoic acid-induced differentiation factor -2.27703
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.27613
PELO pelota homolog (Drosophila) -2.27275
VWF von Willebrand factor -2.27235
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.26719
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.25621
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.256
PLAAT3 phospholipase A and acyltransferase 3 -2.25573
GTF2H5 general transcription factor IIH, polypeptide 5 -2.2507
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.24694
RAB9A RAB9A, member RAS oncogene family -2.24048
PECR peroxisomal trans-2-enoyl-CoA reductase -2.23109
SLC38A2 solute carrier family 38, member 2 -2.22477
MAPK13 mitogen-activated protein kinase 13 -2.22339
CD320 CD320 molecule -2.19684
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.18914
GNPAT glyceronephosphate O-acyltransferase -2.183
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.17945
LOC124907782 dual specificity protein phosphatase 22 -2.1769
ASDURF ASNSD1 upstream open reading frame -2.16572
UPP1 uridine phosphorylase 1 -2.15565
GOLGA6L9 golgin A6 family-like 9 -2.08858
BUD31 BUD31 homolog (S. cerevisiae) -2.0882
OARD1 O-acyl-ADP-ribose deacylase 1 -2.08654
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -2.08633
RTCA RNA 3'-terminal phosphate cyclase -2.08374
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) -2.08064
DTD1 D-tyrosyl-tRNA deacylase 1 -2.08033
ARHGAP29 Rho GTPase activating protein 29 -2.07277
PTGFR prostaglandin F receptor (FP) -2.06575
AHCY adenosylhomocysteinase -2.06366
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -2.05242
TMPRSS3 transmembrane protease, serine 3 -2.04657
TTC13 tetratricopeptide repeat domain 13 -2.0156
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 -2.00661
EMC7 ER membrane protein complex subunit 7 -2.00377