| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | metronidazole 41.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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83 genes differentially expressed following the CRCGN014_HEPG2_24H:A11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 6.97295 |
| GPER1 | G protein-coupled estrogen receptor 1 | 5.91594 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.6662 |
| STK10 | serine/threonine kinase 10 | 4.62159 |
| PIH1D1 | PIH1 domain containing 1 | 4.57129 |
| ATP11B | ATPase, class VI, type 11B | 4.41007 |
| E2F2 | E2F transcription factor 2 | 4.38675 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 4.13506 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 4.09938 |
| STIMATE | STIM activating enhancer | 3.40118 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 3.40017 |
| PLSCR1 | phospholipid scramblase 1 | 3.2635 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 3.23604 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.06511 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 3.00524 |
| TGFB3 | transforming growth factor, beta 3 | 2.82639 |
| RRAGA | Ras-related GTP binding A | 2.81295 |
| NOTCH1 | notch 1 | 2.80263 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 2.69889 |
| CCDC92 | coiled-coil domain containing 92 | 2.65615 |
| MYLK | myosin light chain kinase | 2.53039 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 2.51312 |
| TPD52L2 | tumor protein D52-like 2 | 2.47641 |
| CAPN1 | calpain 1, (mu/I) large subunit | 2.46624 |
| RSF1 | remodeling and spacing factor 1 | 2.43211 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 2.40938 |
| PARP2 | poly (ADP-ribose) polymerase 2 | 2.3257 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 2.31623 |
| MSRA | methionine sulfoxide reductase A | 2.30496 |
| PNKP | polynucleotide kinase 3'-phosphatase | 2.29837 |
| DENND2D | DENN/MADD domain containing 2D | 2.28531 |
| SATB1 | SATB homeobox 1 | 2.22235 |
| CALCB | calcitonin-related polypeptide beta | 2.19972 |
| RXYLT1 | ribitol xylosyltransferase 1 | 2.19682 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 2.19334 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 2.13296 |
| INTS3 | integrator complex subunit 3 | 2.12422 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | 2.11229 |
| BZW2 | basic leucine zipper and W2 domains 2 | 2.08905 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | 2.06784 |
| HPS4 | Hermansky-Pudlak syndrome 4 | 2.03987 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.028 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 2.02761 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | 2.00602 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -7.10458 |
| PCNA | proliferating cell nuclear antigen | -6.15621 |
| HAT1 | histone acetyltransferase 1 | -5.34941 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -5.05065 |
| LDHD | lactate dehydrogenase D | -4.90655 |
| CD320 | CD320 molecule | -4.49817 |
| NGRN | neugrin, neurite outgrowth associated | -4.49123 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.31861 |
| NVL | nuclear VCP-like | -3.49473 |
| CCNB2 | cyclin B2 | -3.40668 |
| COPS7A | COP9 signalosome subunit 7A | -3.2204 |
| DNM1L | dynamin 1-like | -2.91927 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -2.91796 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.71178 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.51005 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.47565 |
| NCK1 | NCK adaptor protein 1 | -2.46764 |
| SNX11 | sorting nexin 11 | -2.39173 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | -2.38263 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -2.37249 |
| NOP2 | NOP2 nucleolar protein | -2.34787 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.3265 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -2.30223 |
| UGDH | UDP-glucose 6-dehydrogenase | -2.29485 |
| GTPBP8 | GTP-binding protein 8 (putative) | -2.25075 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -2.22359 |
| EGF | epidermal growth factor | -2.22097 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.21358 |
| PEG10 | paternally expressed 10 | -2.19286 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.18592 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.16942 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -2.14124 |
| FASTKD1 | FAST kinase domains 1 | -2.10503 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -2.10495 |
| ZNF586 | zinc finger protein 586 | -2.1015 |
| AQP3 | aquaporin 3 (Gill blood group) | -2.0632 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -2.05904 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | -2.0348 |
| IFT57 | intraflagellar transport 57 | -2.01368 |
