CRCGN014_HEPG2_24H:A14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phthalic anhydride 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN014_HEPG2_24H:A14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
JADE2 jade family PHD finger 2 4.88941
CCNF cyclin F 4.80247
CHN1 chimerin 1 4.62803
GSTZ1 glutathione S-transferase zeta 1 4.34544
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.19346
RPP38 ribonuclease P/MRP 38kDa subunit 4.17709
CIAO3 cytosolic iron-sulfur assembly component 3 4.0578
CXCR4 chemokine (C-X-C motif) receptor 4 3.70223
SQOR sulfide quinone oxidoreductase 3.70137
UBQLN2 ubiquilin 2 3.69567
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.42941
STAP2 signal transducing adaptor family member 2 3.37011
MYLK myosin light chain kinase 3.35079
MICALL1 MICAL-like 1 3.30268
STIMATE STIM activating enhancer 3.11685
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.81532
PPARG peroxisome proliferator-activated receptor gamma 2.75482
ABHD6 abhydrolase domain containing 6 2.72623
IDE insulin-degrading enzyme 2.70699
DYNLT3 dynein, light chain, Tctex-type 3 2.63402
NOSIP nitric oxide synthase interacting protein 2.60209
MAP7 microtubule-associated protein 7 2.47121
RXYLT1 ribitol xylosyltransferase 1 2.47118
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.35704
CRYBG1 crystallin beta-gamma domain containing 1 2.35453
CHMP6 charged multivesicular body protein 6 2.22349
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 2.15999
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.14573
MAST2 microtubule associated serine/threonine kinase 2 2.13531

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -7.12527
LDHD lactate dehydrogenase D -7.03935
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.63106
PCNA proliferating cell nuclear antigen -4.63967
MRPS2 mitochondrial ribosomal protein S2 -4.2535
GNAS GNAS complex locus -4.19832
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.09848
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.04001
RGS2 regulator of G-protein signaling 2 -4.01135
UGDH UDP-glucose 6-dehydrogenase -3.93634
CCDC86 coiled-coil domain containing 86 -3.62711
GTPBP8 GTP-binding protein 8 (putative) -3.58715
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.31572
CCNB1 cyclin B1 -3.14764
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.07698
RAP1A RAP1A, member of RAS oncogene family -3.033
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.01626
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.66751
ZDHHC6 zinc finger, DHHC-type containing 6 -2.64256
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.63085
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.39578
WDR11 WD repeat domain 11 -2.25479
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.24253
PRELID3A PRELI domain containing 3A -2.22683
NGFR nerve growth factor receptor -2.18
TIMELESS timeless circadian clock -2.17162
MPC2 mitochondrial pyruvate carrier 2 -2.14584
AIRIM AFG2 interacting ribosome maturation factor -2.11819
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -2.11228
ARMCX1 armadillo repeat containing, X-linked 1 -2.10549
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.05436
ITGB1BP1 integrin beta 1 binding protein 1 -2.04909
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.04629
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 -2.03907
OXA1L oxidase (cytochrome c) assembly 1-like -2.03401
LRRC32 leucine rich repeat containing 32 -2.03361
MKRN3 makorin ring finger protein 3 -2.00932
MPC1 mitochondrial pyruvate carrier 1 -2.00857