CRCGN014_HEPG2_24H:A15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dimethoxyaniline.hcl 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

113 genes differentially expressed following the CRCGN014_HEPG2_24H:A15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 6.93965
MAP7 microtubule-associated protein 7 5.41016
ANO1 anoctamin 1, calcium activated chloride channel 5.10808
EPHA3 EPH receptor A3 4.94973
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.86592
CYCS cytochrome c, somatic 4.09693
SRC SRC proto-oncogene, non-receptor tyrosine kinase 4.04244
KLHL9 kelch-like family member 9 3.3302
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.11462
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.94463
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.91251
LOC122526780 uncharacterized LOC122526780 2.86112
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.80256
CHEK2 checkpoint kinase 2 2.76916
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.7534
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.73917
LAGE3 L antigen family, member 3 2.71762
CBR3 carbonyl reductase 3 2.6822
ADRB2 adrenoceptor beta 2, surface 2.66741
NOSIP nitric oxide synthase interacting protein 2.65539
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.64965
UBQLN2 ubiquilin 2 2.63541
STK10 serine/threonine kinase 10 2.63162
SQOR sulfide quinone oxidoreductase 2.59012
GPER1 G protein-coupled estrogen receptor 1 2.56296
RPL39L ribosomal protein L39-like 2.55612
SFTPB surfactant protein B 2.5367
SKIC8 SKI8 subunit of superkiller complex 2.48958
DENND2D DENN/MADD domain containing 2D 2.48243
BACE2 beta-site APP-cleaving enzyme 2 2.48131
EPHB2 EPH receptor B2 2.44482
BZW2 basic leucine zipper and W2 domains 2 2.44335
PRKCQ protein kinase C, theta 2.44273
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.40979
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.40604
CXCL2 chemokine (C-X-C motif) ligand 2 2.36464
DIPK1A divergent protein kinase domain 1A 2.3425
CCNF cyclin F 2.33249
KLHL21 kelch-like family member 21 2.32631
KIF5C kinesin family member 5C 2.30977
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.2934
MSRA methionine sulfoxide reductase A 2.28977
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.28396
MOK MOK protein kinase 2.28296
HDGFL3 HDGF like 3 2.25857
PYGM phosphorylase, glycogen, muscle 2.17594
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 2.16527
HOXA10 homeobox A10 2.16226
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.15401
ATP11B ATPase, class VI, type 11B 2.15196
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.14578
HLA-DMA major histocompatibility complex, class II, DM alpha 2.14549
RPL3L ribosomal protein L3-like 2.12282
SYTL2 synaptotagmin-like 2 2.12133
MINDY1 MINDY lysine 48 deubiquitinase 1 2.08818
GDAP1 ganglioside induced differentiation associated protein 1 2.08718
SNAP25 synaptosomal-associated protein, 25kDa 2.07695
EPN2 epsin 2 2.06614
CIAO3 cytosolic iron-sulfur assembly component 3 2.05647
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.0534
UPK3A uroplakin 3A 2.05059
PNKP polynucleotide kinase 3'-phosphatase 2.04696
PENK proenkephalin 2.01914
ARSA arylsulfatase A 2.01213

decreased expression

Symbol Name Standardized Value
MRPS2 mitochondrial ribosomal protein S2 -7.16408
TRIB3 tribbles pseudokinase 3 -6.92175
MAPK13 mitogen-activated protein kinase 13 -5.37611
PCNA proliferating cell nuclear antigen -5.26213
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.94651
FBXL12 F-box and leucine-rich repeat protein 12 -4.45745
ACOT9 acyl-CoA thioesterase 9 -3.33517
LAP3 leucine aminopeptidase 3 -3.31358
GOLT1B golgi transport 1B -3.26981
FGFR4 fibroblast growth factor receptor 4 -3.23805
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.05427
TLR4 toll-like receptor 4 -3.00455
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.94957
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.90058
DSG2 desmoglein 2 -2.89141
DNM1L dynamin 1-like -2.82564
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.81111
VAT1 vesicle amine transport 1 -2.76813
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.70031
NECAP2 NECAP endocytosis associated 2 -2.6946
TM9SF3 transmembrane 9 superfamily member 3 -2.6365
EIF5 eukaryotic translation initiation factor 5 -2.59737
PRPF4 pre-mRNA processing factor 4 -2.56305
NUP93 nucleoporin 93kDa -2.52556
NELFB negative elongation factor complex member B -2.51706
PLK1 polo-like kinase 1 -2.51499
FAIM Fas apoptotic inhibitory molecule -2.50658
APIP APAF1 interacting protein -2.49378
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.44442
RGS2 regulator of G-protein signaling 2 -2.41676
SLC35F2 solute carrier family 35, member F2 -2.35554
LDHD lactate dehydrogenase D -2.29132
CCNB2 cyclin B2 -2.27326
MRPS16 mitochondrial ribosomal protein S16 -2.25544
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.24301
RNF167 ring finger protein 167 -2.22767
CDC20 cell division cycle 20 -2.21568
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.14892
HEATR1 HEAT repeat containing 1 -2.12327
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.12175
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.10999
PGAM4 phosphoglycerate mutase family member 4 -2.09497
NUP85 nucleoporin 85kDa -2.07449
GALP galanin-like peptide -2.06927
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.06641
NRIP1 nuclear receptor interacting protein 1 -2.04292
ABITRAM actin binding transcription modulator -2.04088
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.02667
MTCH1 mitochondrial carrier 1 -2.00493