CRCGN014_HEPG2_24H:A18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ciprofibrate 21.38 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

115 genes differentially expressed following the CRCGN014_HEPG2_24H:A18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 10.0
BZW2 basic leucine zipper and W2 domains 2 7.46013
CHMP6 charged multivesicular body protein 6 6.47256
CHN1 chimerin 1 4.54866
GPER1 G protein-coupled estrogen receptor 1 4.49585
RPP38 ribonuclease P/MRP 38kDa subunit 4.14228
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.07532
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.88851
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.84759
GSTZ1 glutathione S-transferase zeta 1 3.81242
PPARG peroxisome proliferator-activated receptor gamma 3.7592
CBR3 carbonyl reductase 3 3.65872
MOK MOK protein kinase 3.63408
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.57207
CXCL2 chemokine (C-X-C motif) ligand 2 3.48328
BLMH bleomycin hydrolase 3.39913
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.18873
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.05503
HLA-DRA major histocompatibility complex, class II, DR alpha 2.89147
GFRA3 GDNF family receptor alpha 3 2.86472
GATA3 GATA binding protein 3 2.84309
JADE2 jade family PHD finger 2 2.811
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 2.76096
MICALL1 MICAL-like 1 2.71226
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.56114
STIMATE STIM activating enhancer 2.51865
ANO1 anoctamin 1, calcium activated chloride channel 2.49289
CTRL chymotrypsin-like 2.4305
IGF1R insulin-like growth factor 1 receptor 2.42501
RXYLT1 ribitol xylosyltransferase 1 2.42016
HPR haptoglobin-related protein 2.39256
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.37764
FZD7 frizzled class receptor 7 2.34687
CDPF1 cysteine-rich, DPF motif domain containing 1 2.33067
DENND2D DENN/MADD domain containing 2D 2.2916
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.28711
CSH2 chorionic somatomammotropin hormone 2 2.28468
CFHR3 complement factor H-related 3 2.25454
AMT aminomethyltransferase 2.24381
PCDHB11 protocadherin beta 11 2.22684
FOXJ3 forkhead box J3 2.22151
CT55 cancer/testis antigen 55 2.18849
ELOVL6 ELOVL fatty acid elongase 6 2.17724
PCDHA2 protocadherin alpha 2 2.16803
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 2.16072
RBMS3 RNA binding motif, single stranded interacting protein 3 2.14532
PRDM8 PR domain containing 8 2.13798
NT5DC3 5'-nucleotidase domain containing 3 2.1363
RNF123 ring finger protein 123 2.12916
CDX4 caudal type homeobox 4 2.12762
TTC21B tetratricopeptide repeat domain 21B 2.12267
TXNL4B thioredoxin-like 4B 2.08377
GALR2 galanin receptor 2 2.08036
PRR36 proline rich 36 2.07377
DCHS2 dachsous cadherin-related 2 2.0627
ZC3H3 zinc finger CCCH-type containing 3 2.05548
GPR173 G protein-coupled receptor 173 2.05127
WNT1 wingless-type MMTV integration site family, member 1 2.04725
DCPH1 damage control phosphatase 1 2.04099
USP19 ubiquitin specific peptidase 19 2.03874
PUM1 pumilio RNA-binding family member 1 2.03869
FGF16 fibroblast growth factor 16 2.03367
C8A complement component 8, alpha polypeptide 2.02625
F9 coagulation factor IX 2.02447
GPBP1L1 GC-rich promoter binding protein 1-like 1 2.01658
TRAPPC8 trafficking protein particle complex 8 2.01636
AQP5 aquaporin 5 2.01237
BMP8B bone morphogenetic protein 8b 2.0096
ZNF516 zinc finger protein 516 2.00659

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -7.74259
LDHD lactate dehydrogenase D -6.1627
CHMP4B charged multivesicular body protein 4B -6.06718
ADI1 acireductone dioxygenase 1 -5.81224
PCNA proliferating cell nuclear antigen -5.64973
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -5.29791
TLCD3A TLC domain containing 3A -5.16245
TM9SF3 transmembrane 9 superfamily member 3 -4.6583
YME1L1 YME1-like 1 ATPase -4.48522
DSG2 desmoglein 2 -4.47361
GOLT1B golgi transport 1B -4.47028
GTPBP8 GTP-binding protein 8 (putative) -4.18265
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.00501
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.00353
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.9063
TRIB3 tribbles pseudokinase 3 -3.85937
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.84069
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.81442
CCNB2 cyclin B2 -3.77466
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.76655
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.74145
CCDC86 coiled-coil domain containing 86 -3.71216
DNM1L dynamin 1-like -3.69733
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.66809
FBXO7 F-box protein 7 -3.66261
C2CD5 C2 calcium-dependent domain containing 5 -3.64191
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.57435
MRPS2 mitochondrial ribosomal protein S2 -3.30342
ITGB1BP1 integrin beta 1 binding protein 1 -3.24916
RFC2 replication factor C (activator 1) 2, 40kDa -3.16732
NGRN neugrin, neurite outgrowth associated -2.86932
CTSD cathepsin D -2.84086
NT5DC2 5'-nucleotidase domain containing 2 -2.58029
VAT1 vesicle amine transport 1 -2.47921
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.47508
CCNB1 cyclin B1 -2.35653
GPKOW G patch domain and KOW motifs -2.3244
TWF2 twinfilin actin binding protein 2 -2.19405
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.16519
TLR4 toll-like receptor 4 -2.11649
NRIP1 nuclear receptor interacting protein 1 -2.09438
RECQL RecQ helicase-like -2.05218
CXADR coxsackie virus and adenovirus receptor -2.03034
CLDN4 claudin 4 -2.02817
PTPRK protein tyrosine phosphatase, receptor type, K -2.02366
CAB39L calcium binding protein 39-like -2.01914