CRCGN014_HEPG2_24H:A22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phthalamide 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

266 genes differentially expressed following the CRCGN014_HEPG2_24H:A22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 9.30155
GPER1 G protein-coupled estrogen receptor 1 5.61353
STAP2 signal transducing adaptor family member 2 5.502
ADRB2 adrenoceptor beta 2, surface 5.4412
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 5.3241
TATDN2 TatD DNase domain containing 2 4.9929
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.93335
CXCL2 chemokine (C-X-C motif) ligand 2 4.776
RPL39L ribosomal protein L39-like 4.7734
MYLK myosin light chain kinase 4.71825
ADGRE5 adhesion G protein-coupled receptor E5 4.71665
LAGE3 L antigen family, member 3 4.70485
MSRA methionine sulfoxide reductase A 4.6747
CCNF cyclin F 4.57358
LYN LYN proto-oncogene, Src family tyrosine kinase 4.41857
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.33935
JADE2 jade family PHD finger 2 4.29215
CCL2 chemokine (C-C motif) ligand 2 4.062
PNKP polynucleotide kinase 3'-phosphatase 4.0099
PEX11A peroxisomal biogenesis factor 11 alpha 3.91105
LPAR2 lysophosphatidic acid receptor 2 3.8239
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.76683
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.76172
GATA3 GATA binding protein 3 3.7482
MOK MOK protein kinase 3.6486
ABHD6 abhydrolase domain containing 6 3.62855
VGLL4 vestigial-like family member 4 3.36892
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 3.34582
MICALL1 MICAL-like 1 3.34395
PPARG peroxisome proliferator-activated receptor gamma 3.23065
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.21255
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 3.04573
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.94747
PDZK1 PDZ domain containing 1 2.9105
GPATCH8 G patch domain containing 8 2.8893
TIAM1 T-cell lymphoma invasion and metastasis 1 2.88297
ZNF589 zinc finger protein 589 2.79485
SNX7 sorting nexin 7 2.76225
NCALD neurocalcin delta 2.76195
SATB1 SATB homeobox 1 2.75945
CDPF1 cysteine-rich, DPF motif domain containing 1 2.73765
PHF2 PHD finger protein 2 2.73225
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.70785
MAP7 microtubule-associated protein 7 2.686
DYNLT3 dynein, light chain, Tctex-type 3 2.6728
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 2.6333
WDR7 WD repeat domain 7 2.6305
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 2.5964
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.58365
PLSCR3 phospholipid scramblase 3 2.5699
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 2.43505
FZD7 frizzled class receptor 7 2.418
TMEM14A transmembrane protein 14A 2.38665
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.34465
CA3 carbonic anhydrase III 2.32225
ADAM10 ADAM metallopeptidase domain 10 2.31018
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.30345
PTER phosphotriesterase related 2.29925
ANO1 anoctamin 1, calcium activated chloride channel 2.2747
CUL4A cullin 4A 2.23163
CCL8 chemokine (C-C motif) ligand 8 2.22885
R3HDM2 R3H domain containing 2 2.2232
CARTPT CART prepropeptide 2.1971
SUSD6 sushi domain containing 6 2.1943
GPHRA golgi pH regulator A 2.1641
FIRRM FIGNL1 interacting regulator of recombination and mitosis 2.16035
MRPS30 mitochondrial ribosomal protein S30 2.1489
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.1346
ASXL2 additional sex combs like transcriptional regulator 2 2.12415
ALG11 ALG11, alpha-1,2-mannosyltransferase 2.121
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.0772
PIAS3 protein inhibitor of activated STAT, 3 2.07225
SETBP1 SET binding protein 1 2.0623
GULP1 GULP, engulfment adaptor PTB domain containing 1 2.05697
ALCAM activated leukocyte cell adhesion molecule 2.05415
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.05205
PDE4B phosphodiesterase 4B, cAMP-specific 2.05005
CT55 cancer/testis antigen 55 2.04725
CPB1 carboxypeptidase B1 (tissue) 2.03735
NPY1R neuropeptide Y receptor Y1 2.03415
MYH2 myosin, heavy chain 2, skeletal muscle, adult 2.0335
CYB5R1 cytochrome b5 reductase 1 2.0335
NAV3 neuron navigator 3 2.0281
SLC39A6 solute carrier family 39 (zinc transporter), member 6 2.02382
TRIM13 tripartite motif containing 13 2.0227
SYNJ2BP synaptojanin 2 binding protein 2.02055
JAK2 Janus kinase 2 2.02055
AGTR1 angiotensin II receptor, type 1 2.01977
FZD10 frizzled class receptor 10 2.01705
ELF2 E74-like factor 2 (ets domain transcription factor) 2.01608
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.01295
CAPRIN2 caprin family member 2 2.0104
HAUS3 HAUS augmin-like complex, subunit 3 2.00715
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 2.00338

decreased expression

Symbol Name Standardized Value
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -9.43585
GNAS GNAS complex locus -6.46437
RFC2 replication factor C (activator 1) 2, 40kDa -6.29653
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.6137
TUBB6 tubulin, beta 6 class V -5.14515
THAP11 THAP domain containing 11 -5.0931
RPIA ribose 5-phosphate isomerase A -5.059
NCK1 NCK adaptor protein 1 -5.03475
PGAM4 phosphoglycerate mutase family member 4 -5.03315
ZDHHC6 zinc finger, DHHC-type containing 6 -5.00885
CDC20 cell division cycle 20 -4.8999
NT5DC2 5'-nucleotidase domain containing 2 -4.8209
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.80635
KDM3A lysine (K)-specific demethylase 3A -4.70905
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.55205
ZNF586 zinc finger protein 586 -4.536
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.49885
NUP85 nucleoporin 85kDa -4.4923
TRIB3 tribbles pseudokinase 3 -4.21425
TM9SF3 transmembrane 9 superfamily member 3 -4.16145
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.1045
FAIM Fas apoptotic inhibitory molecule -4.028
CCNB1 cyclin B1 -3.85955
RPS5 ribosomal protein S5 -3.7096
CHMP4B charged multivesicular body protein 4B -3.64718
PFKP phosphofructokinase, platelet -3.5404
TLR4 toll-like receptor 4 -3.37075
SNX11 sorting nexin 11 -3.3498
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.26305
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.2561
YME1L1 YME1-like 1 ATPase -3.1921
WASHC4 WASH complex subunit 4 -3.02573
ACAA1 acetyl-CoA acyltransferase 1 -2.95725
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.91415
TLCD3A TLC domain containing 3A -2.84945
FBXL12 F-box and leucine-rich repeat protein 12 -2.8384
TMSB10 thymosin beta 10 -2.8129
RPS12 ribosomal protein S12 -2.7904
RPS29 ribosomal protein S29 -2.78705
SUMO4 small ubiquitin-like modifier 4 -2.77545
KCTD2 potassium channel tetramerization domain containing 2 -2.75115
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.73215
FAM216A family with sequence similarity 216, member A -2.7278
RPP30 ribonuclease P/MRP 30kDa subunit -2.6945
ATP5PD ATP synthase peripheral stalk subunit d -2.6659
MRPL58 mitochondrial ribosomal protein L58 -2.6334
RPS8 ribosomal protein S8 -2.61925
B2M beta-2-microglobulin -2.60938
RPL35 ribosomal protein L35 -2.6026
RPS9 ribosomal protein S9 -2.5708
RPL27 ribosomal protein L27 -2.51495
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -2.4995
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.4938
CDR2L cerebellar degeneration-related protein 2-like -2.4861
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -2.48165
MAPK13 mitogen-activated protein kinase 13 -2.4738
MRPS7 mitochondrial ribosomal protein S7 -2.46165
RPS27 ribosomal protein S27 -2.45985
RPL38 ribosomal protein L38 -2.45415
NABP2 nucleic acid binding protein 2 -2.4496
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.44305
NT5C 5', 3'-nucleotidase, cytosolic -2.43435
PCNA proliferating cell nuclear antigen -2.4191
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor -2.41515
HLA-A major histocompatibility complex, class I, A -2.41093
RPL21 ribosomal protein L21 -2.4104
TBCB tubulin folding cofactor B -2.4052
RPS4X ribosomal protein S4, X-linked -2.3883
RPS11 ribosomal protein S11 -2.38555
SNRPG small nuclear ribonucleoprotein polypeptide G -2.38115
RPLP0 ribosomal protein, large, P0 -2.37675
RPL41 ribosomal protein L41 -2.37395
RPL36 ribosomal protein L36 -2.3625
RPL37 ribosomal protein L37 -2.3538
CTNND1 catenin (cadherin-associated protein), delta 1 -2.34768
ARMC6 armadillo repeat containing 6 -2.33355
PCP4 Purkinje cell protein 4 -2.33285
VPS9D1 VPS9 domain containing 1 -2.3296
TBCA tubulin folding cofactor A -2.3272
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.32375
SLC12A8 solute carrier family 12, member 8 -2.32035
DEAF1 DEAF1 transcription factor -2.3203
YBX1 Y box binding protein 1 -2.319
CNBP CCHC-type zinc finger, nucleic acid binding protein -2.31505
RASAL1 RAS protein activator like 1 (GAP1 like) -2.3051
RPL18 ribosomal protein L18 -2.30245
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -2.29885
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.29125
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.29012
RPL30 ribosomal protein L30 -2.2885
PCBP3 poly(rC) binding protein 3 -2.2864
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D -2.2805
TPT1 tumor protein, translationally-controlled 1 -2.27716
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.27325
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.2731
RPS3A ribosomal protein S3A -2.2637
RHEB Ras homolog enriched in brain -2.26122
RPL10A ribosomal protein L10a -2.261
RPL9 ribosomal protein L9 -2.26075
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -2.24525
CD82 CD82 molecule -2.2441
RPS13 ribosomal protein S13 -2.24305
RPS25 ribosomal protein S25 -2.2428
APRT adenine phosphoribosyltransferase -2.24233
RPS19 ribosomal protein S19 -2.24062
BLNK B-cell linker -2.2285
HMG20B high mobility group 20B -2.22627
UBC ubiquitin C -2.21915
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.2064
CLDN4 claudin 4 -2.2047
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.1972
ADI1 acireductone dioxygenase 1 -2.19355
JPT1 Jupiter microtubule associated homolog 1 -2.1914
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -2.18823
CCL20 chemokine (C-C motif) ligand 20 -2.1772
RPS16 ribosomal protein S16 -2.17005
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 -2.1699
RPS15 ribosomal protein S15 -2.16635
EIF4H eukaryotic translation initiation factor 4H -2.1637
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.1629
RPS18 ribosomal protein S18 -2.15965
ZNF430 zinc finger protein 430 -2.1595
RPL12 ribosomal protein L12 -2.15928
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -2.15035
FNTA farnesyltransferase, CAAX box, alpha -2.1405
HLA-C major histocompatibility complex, class I, C -2.14008
ADORA2B adenosine A2b receptor -2.13765
MRPL18 mitochondrial ribosomal protein L18 -2.13755
ZNF146 zinc finger protein 146 -2.137
RPLP1 ribosomal protein, large, P1 -2.134
ATP9A ATPase, class II, type 9A -2.13085
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.1283
KRT4 keratin 4, type II -2.12625
ZW10 zw10 kinetochore protein -2.12605
ATP5PF ATP synthase peripheral stalk subunit F6 -2.1238
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa -2.12065
RPL23A ribosomal protein L23a -2.12046
RPL3 ribosomal protein L3 -2.10849
CTSD cathepsin D -2.1022
RPL8 ribosomal protein L8 -2.10195
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough -2.09805
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.0939
MMP7 matrix metallopeptidase 7 -2.0917
KRCC1 lysine-rich coiled-coil 1 -2.0822
CHMP1A charged multivesicular body protein 1A -2.0801
ACTG1 actin gamma 1 -2.07876
UBL5 ubiquitin-like 5 -2.07715
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.0742
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.07195
RPL7A ribosomal protein L7a -2.0701
GRB2 growth factor receptor-bound protein 2 -2.0677
IL10RB interleukin 10 receptor, beta -2.06765
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -2.0655
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -2.06525
RPL7 ribosomal protein L7 -2.06113
SLC35G2 solute carrier family 35, member G2 -2.0594
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.05577
RPS27A ribosomal protein S27a -2.049
RPL32 ribosomal protein L32 -2.02985
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.02555
RGS2 regulator of G-protein signaling 2 -2.02365
AVPI1 arginine vasopressin-induced 1 -2.02295
U2AF2 U2 small nuclear RNA auxiliary factor 2 -2.0201
RPS10 ribosomal protein S10 -2.01905
EGF epidermal growth factor -2.0172
LDHC lactate dehydrogenase C -2.0134
NCOA4 nuclear receptor coactivator 4 -2.01175
AOPEP aminopeptidase O (putative) -2.01075
ARMC7 armadillo repeat containing 7 -2.0064
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -2.00415
SYT17 synaptotagmin XVII -2.0032
TALDO1 transaldolase 1 -2.0031