CRCGN014_HEPG2_24H:A24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium (e)-2-[4-(dimethylamino)phenyl]diazenesulfonate 21.71 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

242 genes differentially expressed following the CRCGN014_HEPG2_24H:A24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 9.94657
PLS1 plastin 1 7.31842
ADGRE5 adhesion G protein-coupled receptor E5 7.02093
ADRB2 adrenoceptor beta 2, surface 6.97869
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 6.89703
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.84326
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 6.27268
PPARG peroxisome proliferator-activated receptor gamma 6.0143
UBQLN2 ubiquilin 2 5.97237
BZW2 basic leucine zipper and W2 domains 2 5.74347
MAP7 microtubule-associated protein 7 5.27966
CCDC92 coiled-coil domain containing 92 4.383
BLMH bleomycin hydrolase 4.15193
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.9505
C2CD2 C2 calcium-dependent domain containing 2 3.89696
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.73671
HLA-DRA major histocompatibility complex, class II, DR alpha 3.70576
EAPP E2F-associated phosphoprotein 3.68336
RAB21 RAB21, member RAS oncogene family 3.64162
HMOX1 heme oxygenase 1 3.3674
CARMIL1 capping protein regulator and myosin 1 linker 1 3.31842
CCNF cyclin F 3.31052
TIAM1 T-cell lymphoma invasion and metastasis 1 3.30222
INTS3 integrator complex subunit 3 3.30199
SNAP25 synaptosomal-associated protein, 25kDa 3.27496
MOK MOK protein kinase 3.23469
VGLL4 vestigial-like family member 4 3.16338
CAPN1 calpain 1, (mu/I) large subunit 3.15779
SYNGR3 synaptogyrin 3 3.14328
CASC3 cancer susceptibility candidate 3 3.12855
SFTPB surfactant protein B 3.09332
IL1B interleukin 1, beta 3.08428
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.08339
CCDC86 coiled-coil domain containing 86 2.9749
GPER1 G protein-coupled estrogen receptor 1 2.93779
PNKP polynucleotide kinase 3'-phosphatase 2.92765
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.85978
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.84105
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.82812
NOTCH1 notch 1 2.82464
CXCR4 chemokine (C-X-C motif) receptor 4 2.82074
RPP38 ribonuclease P/MRP 38kDa subunit 2.81949
KEAP1 kelch-like ECH-associated protein 1 2.81282
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2.80558
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.77921
CHN1 chimerin 1 2.77556
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.68564
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.6599
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.6495
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.63109
IDE insulin-degrading enzyme 2.62764
RPL39L ribosomal protein L39-like 2.60009
PRKCH protein kinase C, eta 2.58959
EML3 echinoderm microtubule associated protein like 3 2.58252
VAV3 vav 3 guanine nucleotide exchange factor 2.56617
TBC1D19 TBC1 domain family, member 19 2.54077
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.51907
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.51799
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 2.50635
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.50167
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 2.49217
LOC122526780 uncharacterized LOC122526780 2.46072
STK10 serine/threonine kinase 10 2.45591
LYN LYN proto-oncogene, Src family tyrosine kinase 2.43978
RRAGB Ras-related GTP binding B 2.42286
ATAD5 ATPase family, AAA domain containing 5 2.41208
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.4094
MAGEA1 melanoma antigen family A1 2.37479
FABP4 fatty acid binding protein 4, adipocyte 2.3694
MSX2 msh homeobox 2 2.36849
CIAO3 cytosolic iron-sulfur assembly component 3 2.35692
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.35171
CDK19 cyclin-dependent kinase 19 2.34562
CHMP6 charged multivesicular body protein 6 2.34131
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.33778
CFHR5 complement factor H-related 5 2.33198
ANO10 anoctamin 10 2.32522
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 2.32186
PDK3 pyruvate dehydrogenase kinase, isozyme 3 2.31858
RBM10 RNA binding motif protein 10 2.3011
CDC25B cell division cycle 25B 2.29628
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.29591
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.29437
MMP1 matrix metallopeptidase 1 2.29268
SYNM synemin, intermediate filament protein 2.27249
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.27019
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 2.26581
MAOA monoamine oxidase A 2.26221
ANKRD10 ankyrin repeat domain 10 2.25362
SPINK1 serine peptidase inhibitor, Kazal type 1 2.25024
KLHL2 kelch-like family member 2 2.2483
SRI sorcin 2.24499
ISG15 ISG15 ubiquitin-like modifier 2.24494
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.23728
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.22794
HDGFL3 HDGF like 3 2.22704
LPL lipoprotein lipase 2.21058
EPN2 epsin 2 2.20952
RXYLT1 ribitol xylosyltransferase 1 2.2023
OTC ornithine carbamoyltransferase 2.20105
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.19784
GATA3 GATA binding protein 3 2.18993
TPP2 tripeptidyl peptidase II 2.18956
CDO1 cysteine dioxygenase type 1 2.18552
KLRC1 killer cell lectin-like receptor subfamily C, member 1 2.17974
CTPS2 CTP synthase 2 2.17682
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.17455
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 2.17446
ELAC2 elaC ribonuclease Z 2 2.17032
OSBPL11 oxysterol binding protein-like 11 2.16324
AQP1 aquaporin 1 (Colton blood group) 2.15605
CFHR3 complement factor H-related 3 2.1514
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 2.14754
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.14245
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 2.13774
KRT20 keratin 20, type I 2.1375
LMO3 LIM domain only 3 (rhombotin-like 2) 2.13466
IL13RA2 interleukin 13 receptor, alpha 2 2.1275
PRKCZ protein kinase C, zeta 2.12735
SBNO1 strawberry notch homolog 1 (Drosophila) 2.12177
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 2.12163
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 2.11817
C8B complement component 8, beta polypeptide 2.11618
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 2.11465
BCHE butyrylcholinesterase 2.11187
SLC17A2 solute carrier family 17, member 2 2.11045
MAN2B2 mannosidase, alpha, class 2B, member 2 2.10659
DENND2D DENN/MADD domain containing 2D 2.10277
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2.10038
ETNPPL ethanolamine-phosphate phospho-lyase 2.09831
ACACA acetyl-CoA carboxylase alpha 2.09465
GGNBP2 gametogenetin binding protein 2 2.08983
SERINC5 serine incorporator 5 2.07055
LPA lipoprotein, Lp(a) 2.05341
VSIG2 V-set and immunoglobulin domain containing 2 2.05324
IGFBP6 insulin-like growth factor binding protein 6 2.04695
TAC1 tachykinin, precursor 1 2.03847
MAST2 microtubule associated serine/threonine kinase 2 2.0364
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.0317
BAD BCL2-associated agonist of cell death 2.02884
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 2.02799
NSD1 nuclear receptor binding SET domain protein 1 2.02772
RHOBTB2 Rho-related BTB domain containing 2 2.02631
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.02605
AFM afamin 2.02517
LOC100533997 MAGEA10-MAGEA5 readthrough 2.02486
IL1A interleukin 1, alpha 2.01057
JADE3 jade family PHD finger 3 2.00146
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.00134

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -7.53057
GOLT1B golgi transport 1B -7.2155
MRPS2 mitochondrial ribosomal protein S2 -6.83718
LDHD lactate dehydrogenase D -6.83412
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.6924
TSPAN4 tetraspanin 4 -6.63457
PEG10 paternally expressed 10 -6.12628
HACD3 3-hydroxyacyl-CoA dehydratase 3 -6.05218
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -6.03997
PCNA proliferating cell nuclear antigen -5.43899
CCNB2 cyclin B2 -5.02606
YME1L1 YME1-like 1 ATPase -4.75406
ZNF586 zinc finger protein 586 -4.56207
MRPS16 mitochondrial ribosomal protein S16 -4.16421
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.0367
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.90995
GTPBP8 GTP-binding protein 8 (putative) -3.86529
PGAM4 phosphoglycerate mutase family member 4 -3.8332
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.74988
DUSP6 dual specificity phosphatase 6 -3.70545
TRIB3 tribbles pseudokinase 3 -3.63025
TUBB6 tubulin, beta 6 class V -3.58535
COG7 component of oligomeric golgi complex 7 -3.53253
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.47161
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.3419
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.23105
PCCB propionyl CoA carboxylase, beta polypeptide -3.20431
CTNND1 catenin (cadherin-associated protein), delta 1 -3.12913
FBXL12 F-box and leucine-rich repeat protein 12 -3.10036
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.0874
OXA1L oxidase (cytochrome c) assembly 1-like -3.0384
ZNF274 zinc finger protein 274 -2.94819
ENOPH1 enolase-phosphatase 1 -2.82263
TLCD3A TLC domain containing 3A -2.78147
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.77782
NCK1 NCK adaptor protein 1 -2.7698
DDIT4 DNA-damage-inducible transcript 4 -2.75398
PLK1 polo-like kinase 1 -2.74055
THAP11 THAP domain containing 11 -2.69434
CHMP4B charged multivesicular body protein 4B -2.67581
S100A4 S100 calcium binding protein A4 -2.66648
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.651
UGCG UDP-glucose ceramide glucosyltransferase -2.64101
RGS2 regulator of G-protein signaling 2 -2.61874
TWF2 twinfilin actin binding protein 2 -2.60927
FXYD2 FXYD domain containing ion transport regulator 2 -2.58518
ZNF91 zinc finger protein 91 -2.58139
COG4 component of oligomeric golgi complex 4 -2.55745
ISOC1 isochorismatase domain containing 1 -2.49023
LIME1 Lck interacting transmembrane adaptor 1 -2.48098
ACAA1 acetyl-CoA acyltransferase 1 -2.47049
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.46459
C2CD5 C2 calcium-dependent domain containing 5 -2.45705
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.37368
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.35224
URM1 ubiquitin related modifier 1 -2.29085
CCNB1 cyclin B1 -2.2608
NGRN neugrin, neurite outgrowth associated -2.23815
TMEM214 transmembrane protein 214 -2.23599
H2AC25 H2A clustered histone 25 -2.22781
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -2.22567
PSRC1 proline/serine-rich coiled-coil 1 -2.22229
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.21826
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -2.21136
UQCRC2 ubiquinol-cytochrome c reductase core protein II -2.20732
RENBP renin binding protein -2.20464
RHCG Rh family, C glycoprotein -2.20284
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.19856
SLC35F2 solute carrier family 35, member F2 -2.1809
MRPL37 mitochondrial ribosomal protein L37 -2.17849
SCAMP4 secretory carrier membrane protein 4 -2.17252
TBCC tubulin folding cofactor C -2.16913
MRPS18B mitochondrial ribosomal protein S18B -2.16576
SCAMP2 secretory carrier membrane protein 2 -2.15524
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.15474
BCAM basal cell adhesion molecule (Lutheran blood group) -2.12994
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -2.08597
MRPS10 mitochondrial ribosomal protein S10 -2.08477
GRIP2 glutamate receptor interacting protein 2 -2.08139
ASB6 ankyrin repeat and SOCS box containing 6 -2.06629
RFK riboflavin kinase -2.05927
TFRC transferrin receptor -2.0584
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.05711
CCNH cyclin H -2.05116
CCP110 centriolar coiled coil protein 110kDa -2.03895
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.03808
TMEM14B transmembrane protein 14B -2.02892
ATP5F1A ATP synthase F1 subunit alpha -2.02798
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.01447
LITAF lipopolysaccharide-induced TNF factor -2.01322
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.00682
KDM3A lysine (K)-specific demethylase 3A -2.00255
NABP2 nucleic acid binding protein 2 -2.00036