CRCGN014_HEPG2_24H:B03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

321 genes differentially expressed following the CRCGN014_HEPG2_24H:B03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 9.7286
PPARG peroxisome proliferator-activated receptor gamma 8.3719
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.70585
E2F2 E2F transcription factor 2 5.6869
MCOLN1 mucolipin 1 5.27945
LAGE3 L antigen family, member 3 5.24265
RPL39L ribosomal protein L39-like 5.08395
BACE2 beta-site APP-cleaving enzyme 2 5.0323
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.03045
RPP38 ribonuclease P/MRP 38kDa subunit 5.0262
CXCL2 chemokine (C-X-C motif) ligand 2 5.02585
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.024
EGF epidermal growth factor 4.98445
C2CD2 C2 calcium-dependent domain containing 2 4.93755
MAMLD1 mastermind-like domain containing 1 4.90955
CIAO3 cytosolic iron-sulfur assembly component 3 4.7068
ADGRE5 adhesion G protein-coupled receptor E5 4.6702
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.66175
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.6285
KLHL21 kelch-like family member 21 4.55455
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.39545
ABHD6 abhydrolase domain containing 6 4.34643
CCL2 chemokine (C-C motif) ligand 2 4.21505
PLS1 plastin 1 4.04285
GATA3 GATA binding protein 3 3.99707
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.88837
CGRRF1 cell growth regulator with ring finger domain 1 3.83625
IDE insulin-degrading enzyme 3.8229
PEX11A peroxisomal biogenesis factor 11 alpha 3.7356
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.62368
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.57615
PFKL phosphofructokinase, liver 3.49463
MINDY1 MINDY lysine 48 deubiquitinase 1 3.4365
ELL2 elongation factor, RNA polymerase II, 2 3.3731
LYN LYN proto-oncogene, Src family tyrosine kinase 3.37253
MTM1 myotubularin 1 3.3267
TIAM1 T-cell lymphoma invasion and metastasis 1 3.32315
PRKCH protein kinase C, eta 3.2984
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.2619
RXYLT1 ribitol xylosyltransferase 1 3.26163
WWP1 WW domain containing E3 ubiquitin protein ligase 1 3.2186
LACTB2 lactamase, beta 2 3.05985
DENND4A DENN/MADD domain containing 4A 2.9486
CHN1 chimerin 1 2.88105
SLC38A6 solute carrier family 38, member 6 2.84735
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.81667
EVL Enah/Vasp-like 2.79685
KDM5A lysine (K)-specific demethylase 5A 2.77437
WRAP73 WD repeat containing, antisense to TP73 2.772
PPCDC phosphopantothenoylcysteine decarboxylase 2.76295
RAB21 RAB21, member RAS oncogene family 2.74605
STK25 serine/threonine kinase 25 2.7406
GSTZ1 glutathione S-transferase zeta 1 2.73745
GK glycerol kinase 2.7349
GRB10 growth factor receptor-bound protein 10 2.72372
FCGRT Fc fragment of IgG, receptor, transporter, alpha 2.7189
SELENBP1 selenium binding protein 1 2.7041
CCL1 chemokine (C-C motif) ligand 1 2.6788
RXRA retinoid X receptor, alpha 2.67572
BHLHE41 basic helix-loop-helix family, member e41 2.65415
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.64495
MCTP1 multiple C2 domains, transmembrane 1 2.64325
UEVLD UEV and lactate/malate dehyrogenase domains 2.6423
ZBTB43 zinc finger and BTB domain containing 43 2.62455
HABP4 hyaluronan binding protein 4 2.6235
ADGRE2 adhesion G protein-coupled receptor E2 2.6051
BBS7 Bardet-Biedl syndrome 7 2.587
MANEA mannosidase, endo-alpha 2.5835
CCDC88C coiled-coil domain containing 88C 2.5655
SDC4 syndecan 4 2.5612
CEP85 centrosomal protein 85kDa 2.5553
BLTP3B bridge-like lipid transfer protein family member 3B 2.53045
PINK1 PTEN induced putative kinase 1 2.5107
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.50565
GLTP glycolipid transfer protein 2.4982
KLF3 Kruppel-like factor 3 (basic) 2.49015
CHAF1B chromatin assembly factor 1, subunit B (p60) 2.4644
TIPRL TOR signaling pathway regulator 2.45955
ACOT2 acyl-CoA thioesterase 2 2.43885
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.43865
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 2.4281
ACOX1 acyl-CoA oxidase 1, palmitoyl 2.42642
MERTK MER proto-oncogene, tyrosine kinase 2.42543
TTPA tocopherol (alpha) transfer protein 2.41825
OBI1 ORC ubiquitin ligase 1 2.388
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.38385
YEATS4 YEATS domain containing 4 2.37915
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 2.37453
ODF2 outer dense fiber of sperm tails 2 2.3687
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.3672
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.3623
MAP3K8 mitogen-activated protein kinase kinase kinase 8 2.3591
SCARF1 scavenger receptor class F, member 1 2.3432
ADGRE1 adhesion G protein-coupled receptor E1 2.3411
SOD1 superoxide dismutase 1, soluble 2.33725
MARK3 MAP/microtubule affinity-regulating kinase 3 2.3306
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.31848
CD5L CD5 molecule-like 2.31835
MANSC1 MANSC domain containing 1 2.31325
JADE2 jade family PHD finger 2 2.29982
RAP1B RAP1B, member of RAS oncogene family 2.2941
MAP7 microtubule-associated protein 7 2.28518
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.26745
IL3RA interleukin 3 receptor, alpha (low affinity) 2.26375
MEOX1 mesenchyme homeobox 1 2.25895
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 2.25782
TBC1D31 TBC1 domain family, member 31 2.24975
WWC2 WW and C2 domain containing 2 2.24375
CLMN calmin (calponin-like, transmembrane) 2.241
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 2.24073
WASF2 WAS protein family, member 2 2.2407
MMP1 matrix metallopeptidase 1 2.24007
SETD1B SET domain containing 1B 2.2305
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.2256
TUT7 terminal uridylyl transferase 7 2.22115
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.21875
OGFRL1 opioid growth factor receptor-like 1 2.21815
PALS1 protein associated with LIN7 1, MAGUK p55 family member 2.21005
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.20812
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 2.20275
TBCCD1 TBCC domain containing 1 2.20255
AGA aspartylglucosaminidase 2.19605
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 2.19493
WBP4 WW domain binding protein 4 2.19492
GSDMD gasdermin D 2.189
CEP104 centrosomal protein 104kDa 2.18823
KIF15 kinesin family member 15 2.18815
HNF4G hepatocyte nuclear factor 4, gamma 2.1873
TRAF3 TNF receptor-associated factor 3 2.18675
SMIM5 small integral membrane protein 5 2.18655
ANGPTL4 angiopoietin-like 4 2.18275
GPER1 G protein-coupled estrogen receptor 1 2.18222
VSIG2 V-set and immunoglobulin domain containing 2 2.1796
MRTFB myocardin related transcription factor B 2.1681
LPIN2 lipin 2 2.16688
PIWIL2 piwi-like RNA-mediated gene silencing 2 2.1647
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.16175
SEC14L1 SEC14-like 1 (S. cerevisiae) 2.16145
ETFDH electron-transferring-flavoprotein dehydrogenase 2.1614
RIC8B RIC8 guanine nucleotide exchange factor B 2.1597
DRC9 dynein regulatory complex subunit 9 2.1574
RCOR1 REST corepressor 1 2.15705
ICAM2 intercellular adhesion molecule 2 2.15422
CPQ carboxypeptidase Q 2.14948
SIPA1L1 signal-induced proliferation-associated 1 like 1 2.14863
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.148
ETNPPL ethanolamine-phosphate phospho-lyase 2.1445
TRMO tRNA methyltransferase O 2.13685
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.1265
STRN3 striatin, calmodulin binding protein 3 2.12395
OSGEP O-sialoglycoprotein endopeptidase 2.1234
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 2.12265
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.1221
QSER1 glutamine and serine rich 1 2.1153
MTHFSD methenyltetrahydrofolate synthetase domain containing 2.11295
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.0993
FAM131A family with sequence similarity 131, member A 2.09655
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.08575
ACKR3 atypical chemokine receptor 3 2.08195
LOC124900275 extensin-like 2.08098
TCERG1 transcription elongation regulator 1 2.07805
KLHL2 kelch-like family member 2 2.07005
BCAS1 breast carcinoma amplified sequence 1 2.0643
CHD1 chromodomain helicase DNA binding protein 1 2.05475
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 2.05125
NCOA1 nuclear receptor coactivator 1 2.04895
UIMC1 ubiquitin interaction motif containing 1 2.0476
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.0457
SAXO6 stabilizer of axonemal microtubules 6 2.04562
CUL4A cullin 4A 2.04485
GOLGA1 golgin A1 2.0442
FGFR3 fibroblast growth factor receptor 3 2.03893
IFT74 intraflagellar transport 74 2.03835
MAP2K3 mitogen-activated protein kinase kinase 3 2.0356
AFF4 AF4/FMR2 family, member 4 2.03345
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.03323
GIMAP5 GTPase, IMAP family member 5 2.03222
FEM1C fem-1 homolog c (C. elegans) 2.02365
SLC31A2 solute carrier family 31 (copper transporter), member 2 2.0217
YAF2 YY1 associated factor 2 2.0213
HTN3 histatin 3 2.02095
RSF1 remodeling and spacing factor 1 2.01915
RFX2 regulatory factor X, 2 (influences HLA class II expression) 2.018
ETNK1 ethanolamine kinase 1 2.01732
RECQL RecQ helicase-like 2.01557
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.01517
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.01395
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 2.01235
IL17RB interleukin 17 receptor B 2.0117
PRR5 proline rich 5 (renal) 2.00787
GSTM3 glutathione S-transferase mu 3 (brain) 2.0061
CTC1 CTS telomere maintenance complex component 1 2.0046
RMDN1 regulator of microtubule dynamics 1 2.0015
TPK1 thiamin pyrophosphokinase 1 2.00055

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -10.0
ZDHHC6 zinc finger, DHHC-type containing 6 -10.0
TARBP1 TAR (HIV-1) RNA binding protein 1 -7.94635
CCNB1 cyclin B1 -7.7678
PCNA proliferating cell nuclear antigen -7.34355
FBXL12 F-box and leucine-rich repeat protein 12 -7.2933
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -6.7347
NGRN neugrin, neurite outgrowth associated -5.66505
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -5.4373
HMG20B high mobility group 20B -5.401
SLC35F2 solute carrier family 35, member F2 -5.36235
FAIM Fas apoptotic inhibitory molecule -5.25935
DNM1L dynamin 1-like -5.1597
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.147
CDC20 cell division cycle 20 -5.12975
KDM3A lysine (K)-specific demethylase 3A -5.1276
DSG2 desmoglein 2 -5.01465
VAT1 vesicle amine transport 1 -4.96625
LDHD lactate dehydrogenase D -4.87825
CCDC86 coiled-coil domain containing 86 -4.80865
GADD45A growth arrest and DNA-damage-inducible, alpha -4.69775
COG2 component of oligomeric golgi complex 2 -4.68605
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -4.643
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.5618
PLK1 polo-like kinase 1 -4.52605
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.5091
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -4.41568
MRPS2 mitochondrial ribosomal protein S2 -4.3961
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.38895
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -4.3072
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.1498
TRIB3 tribbles pseudokinase 3 -4.0338
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.01535
TM9SF3 transmembrane 9 superfamily member 3 -4.00625
YME1L1 YME1-like 1 ATPase -3.92412
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.83685
TMEM109 transmembrane protein 109 -3.5789
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.5488
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.52065
CHMP4B charged multivesicular body protein 4B -3.37947
TBCB tubulin folding cofactor B -3.11925
GNAS GNAS complex locus -3.08114
ZNF146 zinc finger protein 146 -2.9928
PCGF1 polycomb group ring finger 1 -2.95937
MAIP1 matrix AAA peptidase interacting protein 1 -2.91115
CUTA cutA divalent cation tolerance homolog (E. coli) -2.909
H1-4 H1.4 linker histone, cluster member -2.907
PTPRK protein tyrosine phosphatase, receptor type, K -2.895
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.7841
VAC14 Vac14 homolog (S. cerevisiae) -2.77175
CCNG1 cyclin G1 -2.7351
CPEB1 cytoplasmic polyadenylation element binding protein 1 -2.67645
RTCA RNA 3'-terminal phosphate cyclase -2.6552
RPS5 ribosomal protein S5 -2.59105
NECAB3 N-terminal EF-hand calcium binding protein 3 -2.58755
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.57465
BUB3 BUB3 mitotic checkpoint protein -2.57457
ZNF692 zinc finger protein 692 -2.55235
RNF167 ring finger protein 167 -2.5233
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -2.51845
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -2.4933
WDR37 WD repeat domain 37 -2.47695
RBM42 RNA binding motif protein 42 -2.47635
WDR12 WD repeat domain 12 -2.4761
OLA1 Obg-like ATPase 1 -2.475
CCNC cyclin C -2.44685
UBE2S ubiquitin-conjugating enzyme E2S -2.425
ATP5F1C ATP synthase F1 subunit gamma -2.42287
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -2.3991
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.3758
SSR1 signal sequence receptor, alpha -2.37001
ICE1 interactor of little elongation complex ELL subunit 1 -2.35525
TMEM147 transmembrane protein 147 -2.33435
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.3329
ISCU iron-sulfur cluster assembly enzyme -2.33005
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -2.32912
UCK2 uridine-cytidine kinase 2 -2.32505
CHGB chromogranin B -2.2837
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.28265
HSPE1 heat shock 10kDa protein 1 -2.2797
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -2.25715
ADI1 acireductone dioxygenase 1 -2.2489
FXYD5 FXYD domain containing ion transport regulator 5 -2.2447
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa -2.24385
LYRM4 LYR motif containing 4 -2.2408
IER5 immediate early response 5 -2.2301
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.22785
MSMO1 methylsterol monooxygenase 1 -2.22465
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -2.20885
KIF1A kinesin family member 1A -2.20635
CAPN15 calpain 15 -2.19925
PITPNB phosphatidylinositol transfer protein, beta -2.1976
TEAD3 TEA domain family member 3 -2.1974
MZT2A mitotic spindle organizing protein 2A -2.1963
BICD1 bicaudal D homolog 1 (Drosophila) -2.19265
SNRPA small nuclear ribonucleoprotein polypeptide A -2.18025
APMAP adipocyte plasma membrane associated protein -2.17535
TP53RK TP53 regulating kinase -2.1684
LOC124907782 dual specificity protein phosphatase 22 -2.16665
CAPNS1 calpain, small subunit 1 -2.1636
RPF1 ribosome production factor 1 homolog (S. cerevisiae) -2.15855
SNRPC small nuclear ribonucleoprotein polypeptide C -2.15185
LRRC40 leucine rich repeat containing 40 -2.14905
IKZF5 IKAROS family zinc finger 5 (Pegasus) -2.1225
OXA1L oxidase (cytochrome c) assembly 1-like -2.11345
INSM1 insulinoma-associated 1 -2.11165
STX1A syntaxin 1A (brain) -2.1061
SF3B2 splicing factor 3b, subunit 2, 145kDa -2.09895
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.09485
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 -2.0867
MLPH melanophilin -2.0866
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -2.07925
PGLS 6-phosphogluconolactonase -2.06717
MCFD2 multiple coagulation factor deficiency 2 -2.06453
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -2.0623
MOSPD3 motile sperm domain containing 3 -2.0563
FCMR Fc fragment of IgM receptor -2.05083
PHB2 prohibitin 2 -2.04795
TRAPPC6A trafficking protein particle complex 6A -2.03855
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.03645
CSNK2B casein kinase 2, beta polypeptide -2.03105
MCM6 minichromosome maintenance complex component 6 -2.0149
EMC7 ER membrane protein complex subunit 7 -2.01435
POMP proteasome maturation protein -2.01155
AUP1 ancient ubiquitous protein 1 -2.00565
RPL23A ribosomal protein L23a -2.0049
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.0006