CRCGN014_HEPG2_24H:B06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(9-oxo-9h-fluoren-2-yl)acetamide 20.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

302 genes differentially expressed following the CRCGN014_HEPG2_24H:B06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 9.36466
ABHD4 abhydrolase domain containing 4 7.88197
TXNRD1 thioredoxin reductase 1 6.61193
CBR1 carbonyl reductase 1 6.23601
CNPY3 canopy FGF signaling regulator 3 6.21484
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.52144
STX1A syntaxin 1A (brain) 5.51324
SFTPB surfactant protein B 5.49754
FOSL1 FOS-like antigen 1 5.43816
CXCL2 chemokine (C-X-C motif) ligand 2 5.10445
ALAS1 5'-aminolevulinate synthase 1 4.9832
H2BC12 H2B clustered histone 12 4.94275
SQSTM1 sequestosome 1 4.71184
TIMP2 TIMP metallopeptidase inhibitor 2 4.42252
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.25396
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.14288
SLC35F2 solute carrier family 35, member F2 4.11915
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.92553
MVP major vault protein 3.84514
PPARG peroxisome proliferator-activated receptor gamma 3.70346
KLHL21 kelch-like family member 21 3.64013
BLCAP bladder cancer associated protein 3.63269
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.53657
SQOR sulfide quinone oxidoreductase 3.48545
INPP1 inositol polyphosphate-1-phosphatase 3.39278
AMDHD2 amidohydrolase domain containing 2 3.34669
TMEM50A transmembrane protein 50A 3.31817
STIMATE STIM activating enhancer 3.24382
RBKS ribokinase 3.20562
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.19688
ZFP36 ZFP36 ring finger protein 3.17849
UBQLN2 ubiquilin 2 3.16377
BIRC2 baculoviral IAP repeat containing 2 3.14942
LCN2 lipocalin 2 3.12814
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.10241
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 3.06449
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 3.03115
NGF nerve growth factor (beta polypeptide) 2.96144
TWF2 twinfilin actin binding protein 2 2.92612
PRELID3A PRELI domain containing 3A 2.91496
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2.85739
NOTCH1 notch 1 2.84379
ACOT9 acyl-CoA thioesterase 9 2.82306
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.81438
TEX10 testis expressed 10 2.7778
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.73249
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.69237
BLMH bleomycin hydrolase 2.68844
RALB v-ral simian leukemia viral oncogene homolog B 2.68786
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.66896
BAG2 BCL2-associated athanogene 2 2.65621
GPER1 G protein-coupled estrogen receptor 1 2.65079
OTOR otoraplin 2.64833
GLRX glutaredoxin (thioltransferase) 2.64724
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.62425
ANXA7 annexin A7 2.61374
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.60452
PRKCD protein kinase C, delta 2.60387
MAMLD1 mastermind-like domain containing 1 2.59884
HOXA10 homeobox A10 2.56858
CTSZ cathepsin Z 2.5663
FAM193A family with sequence similarity 193, member A 2.55595
MAST2 microtubule associated serine/threonine kinase 2 2.53568
PRR16 proline rich 16 2.51453
MRPS10 mitochondrial ribosomal protein S10 2.50953
TNNC1 troponin C type 1 (slow) 2.50247
CEMIP2 cell migration inducing hyaluronidase 2 2.48773
KEAP1 kelch-like ECH-associated protein 1 2.48537
INTS3 integrator complex subunit 3 2.47716
LRP10 low density lipoprotein receptor-related protein 10 2.47084
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 2.46547
SLC35F6 solute carrier family 35, member F6 2.45801
MCOLN1 mucolipin 1 2.44945
TAGLN3 transgelin 3 2.4367
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.42671
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.41538
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 2.41489
FASTKD5 FAST kinase domains 5 2.41176
VPS50 VPS50 subunit of EARP/GARPII complex 2.40203
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.39388
NPC1 Niemann-Pick disease, type C1 2.38534
TOMM34 translocase of outer mitochondrial membrane 34 2.37644
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 2.36338
HLA-DRA major histocompatibility complex, class II, DR alpha 2.3601
CRYZ crystallin, zeta (quinone reductase) 2.35437
IL11 interleukin 11 2.34995
SNX19 sorting nexin 19 2.34601
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.33951
SNAP25 synaptosomal-associated protein, 25kDa 2.3385
MAP7 microtubule-associated protein 7 2.33754
ABHD6 abhydrolase domain containing 6 2.3327
PHAF1 phagosome assembly factor 1 2.33249
BYSL bystin-like 2.32731
EGR1 early growth response 1 2.3177
SMCP sperm mitochondria-associated cysteine-rich protein 2.31441
ACVR1 activin A receptor, type I 2.30754
GCM1 glial cells missing homolog 1 (Drosophila) 2.30693
DCAF1 DDB1 and CUL4 associated factor 1 2.28251
GRB10 growth factor receptor-bound protein 10 2.27765
PCBP3 poly(rC) binding protein 3 2.27693
MAP1S microtubule-associated protein 1S 2.26984
UGDH UDP-glucose 6-dehydrogenase 2.26951
IQSEC3 IQ motif and Sec7 domain 3 2.26613
CST8 cystatin 8 (cystatin-related epididymal specific) 2.26537
LAMB3 laminin, beta 3 2.26351
TPD52L2 tumor protein D52-like 2 2.2618
IL13RA2 interleukin 13 receptor, alpha 2 2.25993
ARID5B AT rich interactive domain 5B (MRF1-like) 2.25853
KIF13A kinesin family member 13A 2.25743
INSL6 insulin-like 6 2.25416
CTTN cortactin 2.25028
TRIB1 tribbles pseudokinase 1 2.24753
LPAR4 lysophosphatidic acid receptor 4 2.24543
GLIPR1 GLI pathogenesis-related 1 2.2422
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.2378
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.23714
RPP40 ribonuclease P/MRP 40kDa subunit 2.23619
IFNB1 interferon, beta 1, fibroblast 2.23421
ZIC1 Zic family member 1 2.2263
ZNF385D zinc finger protein 385D 2.22172
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.22105
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 2.2177
OLAH oleoyl-ACP hydrolase 2.21417
CAB39 calcium binding protein 39 2.21211
FGF20 fibroblast growth factor 20 2.21199
MTMR2 myotubularin related protein 2 2.2056
LPIN1 lipin 1 2.20498
PLSCR2 phospholipid scramblase 2 2.20244
GPC1 glypican 1 2.19342
OR2C1 olfactory receptor, family 2, subfamily C, member 1 2.19121
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.19043
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 2.18103
ELL2 elongation factor, RNA polymerase II, 2 2.17872
YAF2 YY1 associated factor 2 2.17681
SMR3A submaxillary gland androgen regulated protein 3A 2.1759
SFRP5 secreted frizzled-related protein 5 2.17531
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.17406
GOLT1A golgi transport 1A 2.17397
GAGE1 G antigen 1 2.17305
GPN1 GPN-loop GTPase 1 2.16716
CRYBA1 crystallin, beta A1 2.16545
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.16388
ASB8 ankyrin repeat and SOCS box containing 8 2.1628
AXIN1 axin 1 2.16184
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2 2.15976
TIAM1 T-cell lymphoma invasion and metastasis 1 2.15674
TDRD1 tudor domain containing 1 2.1481
IFNA13 interferon, alpha 13 2.14652
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.14376
EN1 engrailed homeobox 1 2.13914
CASC3 cancer susceptibility candidate 3 2.13828
RAB21 RAB21, member RAS oncogene family 2.13124
SPATA31A3 SPATA31 subfamily A, member 3 2.13114
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.1264
ANGPT1 angiopoietin 1 2.12573
POMT1 protein-O-mannosyltransferase 1 2.12501
PTPRM protein tyrosine phosphatase, receptor type, M 2.11611
CDHR2 cadherin-related family member 2 2.1115
GPATCH8 G patch domain containing 8 2.11086
NOP14 NOP14 nucleolar protein 2.10331
SOCS4 suppressor of cytokine signaling 4 2.10292
CHMP1B charged multivesicular body protein 1B 2.09623
LUZP2 leucine zipper protein 2 2.08609
MOG myelin oligodendrocyte glycoprotein 2.07309
SCN10A sodium channel, voltage gated, type X alpha subunit 2.07283
NENF neudesin neurotrophic factor 2.07207
CH25H cholesterol 25-hydroxylase 2.07013
FXYD7 FXYD domain containing ion transport regulator 7 2.0643
COLGALT2 collagen beta(1-O)galactosyltransferase 2 2.06314
HABP4 hyaluronan binding protein 4 2.06268
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.05609
IGHMBP2 immunoglobulin mu binding protein 2 2.05118
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.05087
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.05079
PRDX1 peroxiredoxin 1 2.04903
MATN1 matrilin 1, cartilage matrix protein 2.04502
CORO1A coronin, actin binding protein, 1A 2.04411
LRRC41 leucine rich repeat containing 41 2.04397
TMC7 transmembrane channel-like 7 2.04302
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 2.04262
JUN jun proto-oncogene 2.04217
BPHL biphenyl hydrolase-like (serine hydrolase) 2.03888
MEP1B meprin A, beta 2.03882
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 2.03626
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 2.03139
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.02879
DUSP3 dual specificity phosphatase 3 2.02456
OR1E1 olfactory receptor, family 1, subfamily E, member 1 2.01225
SIK3 SIK family kinase 3 2.01222
NQO2 NAD(P)H dehydrogenase, quinone 2 2.00879
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 2.00826
COQ8B coenzyme Q8B 2.00268

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.16363
LDHD lactate dehydrogenase D -6.52068
KDM3A lysine (K)-specific demethylase 3A -6.29094
VAT1 vesicle amine transport 1 -5.76373
C2CD5 C2 calcium-dependent domain containing 5 -5.20523
ISOC1 isochorismatase domain containing 1 -4.96981
TOP2A topoisomerase (DNA) II alpha 170kDa -4.77999
CDK1 cyclin-dependent kinase 1 -4.71202
CDC20 cell division cycle 20 -4.65202
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.57829
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.49236
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -4.47109
UBE2C ubiquitin-conjugating enzyme E2C -4.41368
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.34165
MELK maternal embryonic leucine zipper kinase -4.1803
CCNA2 cyclin A2 -4.12502
TSPAN4 tetraspanin 4 -4.10848
RFC2 replication factor C (activator 1) 2, 40kDa -4.05984
PSRC1 proline/serine-rich coiled-coil 1 -4.04945
THAP11 THAP domain containing 11 -3.99373
TMEM97 transmembrane protein 97 -3.97984
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.90734
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.73294
HSPB1 heat shock 27kDa protein 1 -3.66453
HADH hydroxyacyl-CoA dehydrogenase -3.65314
PYCR1 pyrroline-5-carboxylate reductase 1 -3.61784
PGM1 phosphoglucomutase 1 -3.61445
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.5683
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.54224
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.41924
CHMP4B charged multivesicular body protein 4B -3.34295
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.3267
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.30164
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.14962
AURKB aurora kinase B -3.1278
HMG20B high mobility group 20B -3.11084
PECR peroxisomal trans-2-enoyl-CoA reductase -3.10915
NT5DC2 5'-nucleotidase domain containing 2 -3.07259
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.07186
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.0437
TRIB3 tribbles pseudokinase 3 -3.02349
CCNB1 cyclin B1 -3.02271
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.02015
COG2 component of oligomeric golgi complex 2 -2.9369
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.8419
PDZD2 PDZ domain containing 2 -2.80191
S100A4 S100 calcium binding protein A4 -2.7788
DDB2 damage-specific DNA binding protein 2, 48kDa -2.77141
PLK1 polo-like kinase 1 -2.75551
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.74318
PTPRK protein tyrosine phosphatase, receptor type, K -2.73406
TM9SF3 transmembrane 9 superfamily member 3 -2.70902
TERT telomerase reverse transcriptase -2.65607
ECH1 enoyl CoA hydratase 1, peroxisomal -2.65294
ENO2 enolase 2 (gamma, neuronal) -2.64406
VAV3 vav 3 guanine nucleotide exchange factor -2.61296
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.59775
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.58687
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.58588
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.58516
VRK1 vaccinia related kinase 1 -2.58162
FANCG Fanconi anemia, complementation group G -2.57532
CDT1 chromatin licensing and DNA replication factor 1 -2.56838
RRM1 ribonucleotide reductase M1 -2.5648
SOAT2 sterol O-acyltransferase 2 -2.47099
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.45913
HMGB2 high mobility group box 2 -2.45261
FGFR4 fibroblast growth factor receptor 4 -2.44313
HMGA2 high mobility group AT-hook 2 -2.4312
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.41982
NCAPD2 non-SMC condensin I complex, subunit D2 -2.3811
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.37988
EDN1 endothelin 1 -2.3651
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.36139
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.35662
FBXO5 F-box protein 5 -2.34575
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.34188
CRELD2 cysteine-rich with EGF-like domains 2 -2.33705
TEDC2 tubulin epsilon and delta complex 2 -2.24708
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.24207
NDC80 NDC80 kinetochore complex component -2.23116
KLHDC2 kelch domain containing 2 -2.20261
MCM6 minichromosome maintenance complex component 6 -2.19762
DDIT4 DNA-damage-inducible transcript 4 -2.19715
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.18567
H2AZ1 H2A.Z variant histone 1 -2.17323
CCDC92 coiled-coil domain containing 92 -2.14786
DUSP6 dual specificity phosphatase 6 -2.1463
ADISSP adipose secreted signaling protein -2.13825
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -2.1367
RNF167 ring finger protein 167 -2.13458
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.11004
SH3D19 SH3 domain containing 19 -2.10818
PALM paralemmin -2.10792
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.10574
TLCD3A TLC domain containing 3A -2.10079
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.07422
PUM2 pumilio RNA-binding family member 2 -2.0708
S100A1 S100 calcium binding protein A1 -2.05719
ZWINT ZW10 interacting kinetochore protein -2.04658
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 -2.04415
RRM2 ribonucleotide reductase M2 -2.04368
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.04033
PRC1 protein regulator of cytokinesis 1 -2.03352
TMEM106C transmembrane protein 106C -2.03137
NEMF nuclear export mediator factor -2.01768
TRIM22 tripartite motif containing 22 -2.01643
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.01321
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.00535
CCDC85B coiled-coil domain containing 85B -2.00053