CRCGN014_HEPG2_24H:B07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description coumarin 40.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

105 genes differentially expressed following the CRCGN014_HEPG2_24H:B07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 7.08767
CXCL2 chemokine (C-X-C motif) ligand 2 5.33945
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.31391
CSK c-src tyrosine kinase 5.03172
CHMP6 charged multivesicular body protein 6 4.89963
ADRB2 adrenoceptor beta 2, surface 4.55888
GATA3 GATA binding protein 3 4.51097
CBR3 carbonyl reductase 3 4.38785
BACE2 beta-site APP-cleaving enzyme 2 3.88026
EPN2 epsin 2 3.72206
SNAP25 synaptosomal-associated protein, 25kDa 3.70156
CHN1 chimerin 1 3.61469
PRAF2 PRA1 domain family, member 2 3.59659
MCM3 minichromosome maintenance complex component 3 3.45026
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.42929
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.35305
RPL39L ribosomal protein L39-like 3.34689
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.27246
KLHL9 kelch-like family member 9 3.20557
RPP38 ribonuclease P/MRP 38kDa subunit 3.11748
ADAM10 ADAM metallopeptidase domain 10 3.09446
CDPF1 cysteine-rich, DPF motif domain containing 1 3.0907
TRAM2 translocation associated membrane protein 2 3.0024
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.98131
PRR15L proline rich 15-like 2.94572
UBQLN2 ubiquilin 2 2.92783
ABI3BP ABI family, member 3 (NESH) binding protein 2.83555
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.75774
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.7513
PLSCR1 phospholipid scramblase 1 2.67292
HLA-DRA major histocompatibility complex, class II, DR alpha 2.63026
PEX11A peroxisomal biogenesis factor 11 alpha 2.56037
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.54033
FPGS folylpolyglutamate synthase 2.44217
CCL2 chemokine (C-C motif) ligand 2 2.41359
IRF2 interferon regulatory factor 2 2.32999
PLA2G2E phospholipase A2, group IIE 2.27689
NUP93 nucleoporin 93kDa 2.2662
TIAM1 T-cell lymphoma invasion and metastasis 1 2.25642
TCL1A T-cell leukemia/lymphoma 1A 2.24706
PFKL phosphofructokinase, liver 2.23922
JADE2 jade family PHD finger 2 2.20199
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.19439
MACIR macrophage immunometabolism regulator 2.17104
FBXO22 F-box protein 22 2.1658
PPARG peroxisome proliferator-activated receptor gamma 2.15181
CDK4 cyclin-dependent kinase 4 2.14748
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 2.14663
HTN1 histatin 1 2.12603
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.1196
OR1E2 olfactory receptor, family 1, subfamily E, member 2 2.10805
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.0966
AMDHD2 amidohydrolase domain containing 2 2.08855
HTN3 histatin 3 2.08781
GLDC glycine dehydrogenase (decarboxylating) 2.08515
GRWD1 glutamate-rich WD repeat containing 1 2.07342
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.03077
FLRT1 fibronectin leucine rich transmembrane protein 1 2.00036

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -10.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.08276
DSG2 desmoglein 2 -4.60222
DERA deoxyribose-phosphate aldolase (putative) -4.05381
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.86218
RNF167 ring finger protein 167 -3.68543
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.67484
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.58496
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.51353
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.46278
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.45677
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.40001
OXA1L oxidase (cytochrome c) assembly 1-like -3.20603
TM9SF3 transmembrane 9 superfamily member 3 -3.16246
TRIB3 tribbles pseudokinase 3 -3.16243
RPIA ribose 5-phosphate isomerase A -3.09569
ZDHHC6 zinc finger, DHHC-type containing 6 -3.014
LDHD lactate dehydrogenase D -2.96361
GDF15 growth differentiation factor 15 -2.95686
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.95631
NVL nuclear VCP-like -2.86182
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.82728
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.76212
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.59733
SLC35F2 solute carrier family 35, member F2 -2.57591
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.56954
HEATR1 HEAT repeat containing 1 -2.41971
CRELD2 cysteine-rich with EGF-like domains 2 -2.41457
SPAG4 sperm associated antigen 4 -2.39938
XPO7 exportin 7 -2.36319
CD320 CD320 molecule -2.34936
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.33604
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.31318
CCDC86 coiled-coil domain containing 86 -2.31164
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.30945
CDC20 cell division cycle 20 -2.24791
CHMP4B charged multivesicular body protein 4B -2.19107
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.17496
FKBP4 FK506 binding protein 4, 59kDa -2.17345
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.12394
FASTKD1 FAST kinase domains 1 -2.11997
RAI14 retinoic acid induced 14 -2.11631
ADGRF5 adhesion G protein-coupled receptor F5 -2.06273
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.05743
AUP1 ancient ubiquitous protein 1 -2.05307
ACP5 acid phosphatase 5, tartrate resistant -2.04183
CTSD cathepsin D -2.00194